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Piscaer I, van den Ouweland JMW, Vermeersch K, et al. Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease. J Clin Med. 2019;8(8)doi: 10.3390/jcm8081116.
Piscaer, I., van den Ouweland, J. M. W., Vermeersch, K., Reynaert, N. L., Franssen, F. M. E., Keene, S., Wouters, E. F. M., Janssens, W., Vermeer, C., & Janssen, R. (2019). Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease. Journal of clinical medicine, 8(8), . https://doi.org/10.3390/jcm8081116
Piscaer, Ianthe, et al. "Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease." Journal of clinical medicine vol. 8,8 (2019). doi: https://doi.org/10.3390/jcm8081116
Piscaer I, van den Ouweland JMW, Vermeersch K, Reynaert NL, Franssen FME, Keene S, Wouters EFM, Janssens W, Vermeer C, Janssen R. Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease. J Clin Med. 2019 Jul 27;8(8). doi: 10.3390/jcm8081116. PMID: 31357639; PMCID: PMC6724066.
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J Clin Med. 2019 Jul 27;8(8). doi: 10.3390/jcm8081116.

Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease.

Journal of clinical medicine

Ianthe Piscaer, Jody M W van den Ouweland, Kristina Vermeersch, Niki L Reynaert, Frits M E Franssen, Spencer Keene, Emiel F M Wouters, Wim Janssens, Cees Vermeer, Rob Janssen

Affiliations

  1. Department of Respiratory Medicine, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands. [email protected].
  2. Clinical Chemistry, Canisius-Wilhelmina Hospital, 6532 SZ Nijmegen, The Netherlands.
  3. Laboratory of Respiratory Diseases, Catholic University Leuven, 3000 Leuven, Belgium.
  4. Department of Respiratory Medicine, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands.
  5. CIRO, Centre of Expertise for Chronic Organ Failure, 6085 NM Horn, The Netherlands.
  6. Department of Respiratory Medicine, University of Birmingham, Birmingham B15 2TT, UK.
  7. Department of Respiratory Medicine, Catholic University Leuven, 3000 Leuven, Belgium.
  8. R&D Group VitaK, Maastricht University, 6229 EV Maastricht, The Netherlands.
  9. Department of Pulmonary Medicine, Canisius-Wilhelmina Hospital, 6532 SZ Nijmegen, The Netherlands.

PMID: 31357639 PMCID: PMC6724066 DOI: 10.3390/jcm8081116

Abstract

Elastin degradation is accelerated in chronic obstructive pulmonary disease (COPD) and is partially regulated by Matrix Gla Protein (MGP), via a vitamin K-dependent pathway. The aim was to assess vitamin K status in COPD as well as associations between vitamin K status, elastin degradation, lung function parameters and mortality. A total of 192 COPD patients and 186 age-matched controls were included. In addition to this, 290 COPD patients from a second independent longitudinal cohort were also included. Vitamin K status was assessed by measuring plasma inactive MGP levels and rates of elastin degradation by measuring plasma desmosine levels. Reduced vitamin K status was found in COPD patients compared to smoking controls (

Keywords: chronic obstructive pulmonary disease; desmosine; elastin degradation; matrix Gla protein; vitamin K

References

  1. Haemostasis. 2000 Nov-Dec;30(6):298-307 - PubMed
  2. Circulation. 2004 Nov 30;110(22):3480-7 - PubMed
  3. Adv Protein Chem. 2005;70:437-61 - PubMed
  4. Am J Pathol. 2006 Feb;168(2):490-8 - PubMed
  5. Chest. 2007 May;131(5):1363-71 - PubMed
  6. Arterioscler Thromb Vasc Biol. 2008 May;28(5):856-62 - PubMed
  7. J Vasc Res. 2008;45(5):427-36 - PubMed
  8. J Biol Chem. 2009 Jun 19;284(25):17092-101 - PubMed
  9. Am J Clin Nutr. 2010 May;91(5):1348-58 - PubMed
  10. Thromb Haemost. 2010 Oct;104(4):811-22 - PubMed
  11. J Am Soc Nephrol. 2011 Feb;22(2):387-95 - PubMed
  12. Ann Intern Med. 2012 Jan 17;156(2):105-14 - PubMed
  13. Thorax. 2012 Jul;67(7):606-12 - PubMed
  14. Am J Respir Crit Care Med. 2012 Jul 1;186(1):88-95 - PubMed
  15. PLoS One. 2012;7(12):e51048 - PubMed
  16. Trends Mol Med. 2013 Apr;19(4):217-26 - PubMed
  17. COPD. 2013 Jun;10(3):367-77 - PubMed
  18. Anal Biochem. 2013 Sep 15;440(2):158-65 - PubMed
  19. Sarcoidosis Vasc Diffuse Lung Dis. 2013 Aug 01;30(2):121-7 - PubMed
  20. Atherosclerosis. 2014 Jul;235(1):162-8 - PubMed
  21. BMC Pulm Med. 2014 May 26;14:90 - PubMed
  22. Lancet Respir Med. 2015 Feb;3(2):120-130 - PubMed
  23. Chest. 2016 Jan;149(1):53-61 - PubMed
  24. Mediators Inflamm. 2015;2015:862086 - PubMed
  25. Respir Res. 2015 Sep 16;16:110 - PubMed
  26. Dermatoendocrinol. 2015 Jan 21;6(1):e968490 - PubMed
  27. Eur Respir J. 2016 May;47(5):1365-73 - PubMed
  28. Eur Respir J. 2016 Jun;47(6):1776-84 - PubMed
  29. Am J Respir Crit Care Med. 2017 Mar 1;195(5):557-582 - PubMed
  30. Chronic Obstr Pulm Dis. 2014 May 6;1(1):115-124 - PubMed
  31. Chronic Obstr Pulm Dis. 2016 Nov 18;4(1):34-44 - PubMed
  32. Respir Res. 2017 Nov 13;18(1):189 - PubMed
  33. J Biol Chem. 1988 Aug 15;263(23):11033-6 - PubMed
  34. Eur Respir J Suppl. 1993 Mar;16:5-40 - PubMed

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