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J Org Chem. 2019 Sep 06;84(17):10814-10824. doi: 10.1021/acs.joc.9b01363. Epub 2019 Aug 23.

Metal and Oxidant-Free Brønsted Acid-Mediated Cascade Reaction to Substituted Benzofurans.

The Journal of organic chemistry

Giacomo Mari, Cecilia Ciccolini, Lucia De Crescentini, Gianfranco Favi, Stefania Santeusanio, Michele Mancinelli, Fabio Mantellini

Affiliations

  1. Department of Biomolecular Sciences , University of Urbino "Carlo Bo" , Via I Maggetti 24 , 61029 Urbino , Province of Pesaro and Urbino , Italy.
  2. Department of Industrial Chemistry "Toso Montanari" , University of Bologna , Viale del Risorgimento 4 , 40136 Bologna (Bo) , Italy.

PMID: 31407579 DOI: 10.1021/acs.joc.9b01363

Abstract

Substituted hydroxy-benzofurans are easily accessible by treatment of resorcinols and 1,2-diaza-1,3-dienes (DDs) under acidic conditions. The reaction happens through an uncommon Michael reaction between aromatic derivatives as aromatic C(sp

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