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Simpson JD, Smith SA, Thurecht KJ, et al. Engineered Polymeric Materials for Biological Applications: Overcoming Challenges of the Bio-Nano Interface. Polymers (Basel). 2019;11(9)doi: 10.3390/polym11091441.
Simpson, J. D., Smith, S. A., Thurecht, K. J., & Such, G. (2019). Engineered Polymeric Materials for Biological Applications: Overcoming Challenges of the Bio-Nano Interface. Polymers, 11(9), . https://doi.org/10.3390/polym11091441
Simpson, Joshua D, et al. "Engineered Polymeric Materials for Biological Applications: Overcoming Challenges of the Bio-Nano Interface." Polymers vol. 11,9 (2019). doi: https://doi.org/10.3390/polym11091441
Simpson JD, Smith SA, Thurecht KJ, Such G. Engineered Polymeric Materials for Biological Applications: Overcoming Challenges of the Bio-Nano Interface. Polymers (Basel). 2019 Sep 02;11(9). doi: 10.3390/polym11091441. PMID: 31480780; PMCID: PMC6780590.
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Polymers (Basel). 2019 Sep 02;11(9). doi: 10.3390/polym11091441.

Engineered Polymeric Materials for Biological Applications: Overcoming Challenges of the Bio-Nano Interface.

Polymers

Joshua D Simpson, Samuel A Smith, Kristofer J Thurecht, Georgina Such

Affiliations

  1. Centre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology, ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and ARC Training Centre for Innovation in Biomedical Imaging Technology, the University of Queensland, St Lucia, QLD, 4072, Australia.
  2. School of Chemistry, University of Melbourne, Parkville, VIC, 3010, Australia.
  3. Centre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology, ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and ARC Training Centre for Innovation in Biomedical Imaging Technology, the University of Queensland, St Lucia, QLD, 4072, Australia. [email protected].
  4. School of Chemistry, University of Melbourne, Parkville, VIC, 3010, Australia. [email protected].

PMID: 31480780 PMCID: PMC6780590 DOI: 10.3390/polym11091441

Abstract

Nanomedicine has generated significant interest as an alternative to conventional cancertherapy due to the ability for nanoparticles to tune cargo release. However, while nanoparticletechnology has promised significant benefit, there are still limited examples of nanoparticles inclinical practice. The low translational success of nanoparticle research is due to the series ofbiological roadblocks that nanoparticles must migrate to be effective, including blood and plasmainteractions, clearance, extravasation, and tumor penetration, through to cellular targeting,internalization, and endosomal escape. It is important to consider these roadblocks holistically inorder to design more effective delivery systems. This perspective will discuss how nanoparticlescan be designed to migrate each of these biological challenges and thus improve nanoparticledelivery systems in the future. In this review, we have limited the literature discussed to studiesinvestigating the impact of polymer nanoparticle structure or composition on therapeutic deliveryand associated advancements. The focus of this review is to highlight the impact of nanoparticlecharacteristics on the interaction with different biological barriers. More specific studies/reviewshave been referenced where possible.

Keywords: biodistribution; cellular compartmentalization; cellular trafficking; nanomedicine; nanoparticle fate

Conflict of interest statement

The authors declare no conflicts of interest.

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