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Vital M, Rud T, Rath S, et al. Diversity of Bacteria Exhibiting Bile Acid-inducible 7α-dehydroxylation Genes in the Human Gut. Comput Struct Biotechnol J. 2019;17:1016-1019doi: 10.1016/j.csbj.2019.07.012.
Vital, M., Rud, T., Rath, S., Pieper, D. H., & Schlüter, D. (2019). Diversity of Bacteria Exhibiting Bile Acid-inducible 7α-dehydroxylation Genes in the Human Gut. Computational and structural biotechnology journal, 171016-1019. https://doi.org/10.1016/j.csbj.2019.07.012
Vital, Marius, et al. "Diversity of Bacteria Exhibiting Bile Acid-inducible 7α-dehydroxylation Genes in the Human Gut." Computational and structural biotechnology journal vol. 17 (2019): 1016-1019. doi: https://doi.org/10.1016/j.csbj.2019.07.012
Vital M, Rud T, Rath S, Pieper DH, Schlüter D. Diversity of Bacteria Exhibiting Bile Acid-inducible 7α-dehydroxylation Genes in the Human Gut. Comput Struct Biotechnol J. 2019 Jul 26;17:1016-1019. doi: 10.1016/j.csbj.2019.07.012. eCollection 2019. PMID: 31428294; PMCID: PMC6692061.
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Comput Struct Biotechnol J. 2019 Jul 26;17:1016-1019. doi: 10.1016/j.csbj.2019.07.012. eCollection 2019.

Diversity of Bacteria Exhibiting Bile Acid-inducible 7α-dehydroxylation Genes in the Human Gut.

Computational and structural biotechnology journal

Marius Vital, Tatjana Rud, Silke Rath, Dietmar H Pieper, Dirk Schlüter

Affiliations

  1. Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, 30625 Hannover, Germany.
  2. Microbial Interactions and Processes Research Group, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.

PMID: 31428294 PMCID: PMC6692061 DOI: 10.1016/j.csbj.2019.07.012

Abstract

The secondary bile acids deoxycholic acid (DCA) and lithocholic acid (LCA), formed by gut microbiota from primary bile acids via a multi-step 7α-dehydroxylation reaction, have wide-ranging effects on host metabolism and play an important role in health and disease. A few 7α-dehydroxylating strains have been isolated, where bile acid-inducible (

Keywords: 7α-dehydroxylation; Bile acids; Gut microbiota; Metagenomics; Microbiome; Systems biology

Conflict of interest statement

There is no conflict of interest.

References

  1. Appl Environ Microbiol. 2000 Mar;66(3):1107-13 - PubMed
  2. J Lipid Res. 2006 Feb;47(2):241-59 - PubMed
  3. PLoS One. 2010 Mar 10;5(3):e9490 - PubMed
  4. J Comput Biol. 2012 May;19(5):455-77 - PubMed
  5. Bioinformatics. 2014 Jul 15;30(14):2068-9 - PubMed
  6. Pharmacol Rev. 2014 Oct;66(4):948-83 - PubMed
  7. Nature. 2015 Jan 8;517(7533):205-8 - PubMed
  8. Nat Methods. 2015 Jan;12(1):59-60 - PubMed
  9. Gut Microbes. 2016;7(1):22-39 - PubMed
  10. Genome Biol. 2016 Jun 20;17(1):132 - PubMed
  11. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Mar;1863(3):276-283 - PubMed
  12. J Microbiol. 2018 Apr;56(4):280-285 - PubMed
  13. Science. 2018 May 25;360(6391): - PubMed
  14. Microbiome. 2018 Sep 28;6(1):174 - PubMed
  15. Cell. 2019 Jan 24;176(3):649-662.e20 - PubMed
  16. Nat Biotechnol. 2019 Feb;37(2):179-185 - PubMed
  17. Nat Biotechnol. 2019 Feb;37(2):186-192 - PubMed
  18. Nature. 2019 Apr;568(7753):499-504 - PubMed
  19. PLoS Pathog. 2019 Mar 7;15(3):e1007581 - PubMed

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