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Wasyluk T, Obrzut B, Gałązka K, et al. Uterine myoma with massive lymphocytic infiltration - case report. Prz Menopauzalny. 2019;18(2):123-125doi: 10.5114/pm.2019.86838.
Wasyluk, T., Obrzut, B., Gałązka, K., Żmuda, M., Obrzut, M., & Darmochwał-Kolarz, D. (2019). Uterine myoma with massive lymphocytic infiltration - case report. Przeglad menopauzalny = Menopause review, 18(2), 123-125. https://doi.org/10.5114/pm.2019.86838
Wasyluk, Tomasz, et al. "Uterine myoma with massive lymphocytic infiltration - case report." Przeglad menopauzalny = Menopause review vol. 18,2 (2019): 123-125. doi: https://doi.org/10.5114/pm.2019.86838
Wasyluk T, Obrzut B, Gałązka K, Żmuda M, Obrzut M, Darmochwał-Kolarz D. Uterine myoma with massive lymphocytic infiltration - case report. Prz Menopauzalny. 2019 Jun;18(2):123-125. doi: 10.5114/pm.2019.86838. Epub 2019 Jun 28. PMID: 31485209; PMCID: PMC6719633.
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Prz Menopauzalny. 2019 Jun;18(2):123-125. doi: 10.5114/pm.2019.86838. Epub 2019 Jun 28.

Uterine myoma with massive lymphocytic infiltration - case report.

Przeglad menopauzalny = Menopause review

Tomasz Wasyluk, Bogdan Obrzut, Krystyna Gałązka, Marcin Żmuda, Marzanna Obrzut, Dorota Darmochwał-Kolarz

Affiliations

  1. Department of Obstetrics and Gynaecology, Provincial Clinical Hospital No. 2 in Rzeszow, Poland.
  2. Department of Pathomorphology, Jagiellonian University Medical College, Krakow, Poland.
  3. Department of Clinical Pathomorphology, Provincial Clinical Hospital No. 2 in Rzeszow, Poland.
  4. Institute of Nursing and Health Sciences, Faculty of Medicine, University of Rzeszow, Poland.
  5. Department of Gynaecology and Obstetrics, Institute of Experimental and Clinical Medicine, Faculty of Medicine, University of Rzeszow, Poland.

PMID: 31485209 PMCID: PMC6719633 DOI: 10.5114/pm.2019.86838

Abstract

INTRODUCTION: Uterine leiomyomas are the most common neoplasm of the uterus in women. Massive lymphocytic infiltration in a myoma is an unusual finding. It is characterised by the varying intensity of lymphocyte infiltration, the presence of scattered plasma cells, eosinophilia, and rarely, other items. We would like to call attention to such a rare lesion.

CASE DESCRIPTION: We present the case of a 31-year-old woman who had undergone surgical excision of a uterine tumour. Grossly, it had the typical uterine smooth muscle wall consistency. The microscopic examination revealed leiomyoma with heavy infiltration composed mainly of lymphocytes. On immunohistochemistry, in the lymphocytic infiltrate the T mature (CD3+/CD5+/TdT-) lymphocytes, small and of cytotoxic (CD8+/CD56-) type, prevailed, with moderate proliferative activity (expression of Ki67 found in ca. 30-40% of the cells), whereas B lymphocytes (CD20+/CD5-/TdT-) were innumerous and present in nodular aggregates. Despite a strong suspicion of neoplastic lymphoproliferation, the histopathological diagnosis was: leiomyoma with massive lymphoid infiltration. The cause of this feature is not known, although the gonadotropin-releasing hormone agonist and post-menopausal processes may promote such transformations. In differential diagnosis, malignant lymphoma, inflammatory pseudotumour, and pyomyoma should be included.

CONCLUSIONS: Lymphocytic infiltration within the uterine myoma is rare. The recognition of its distinct histological features is important to avoid possible misdiagnosis.

Keywords: gonadotropins; leiomyoma; lymphoma; menopause; myoma; neoplasms

Conflict of interest statement

The authors report no conflict of interest.

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