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Gil M, González-González R, Vázquez-Calvo A, et al. Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP. J Clin Med. 2019;8(9)doi: 10.3390/jcm8091442.
Gil, M., González-González, R., Vázquez-Calvo, A., Álvarez-Gutiérrez, A., Martín-Acebes, M. A., Praena, B., Bello-Morales, R., Saiz, J. C., López-Guerrero, J. A., Tabarés, E., & Sobrino, F. (2019). Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP. Journal of clinical medicine, 8(9), . https://doi.org/10.3390/jcm8091442
Gil, Miguel, et al. "Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP." Journal of clinical medicine vol. 8,9 (2019). doi: https://doi.org/10.3390/jcm8091442
Gil M, González-González R, Vázquez-Calvo A, Álvarez-Gutiérrez A, Martín-Acebes MA, Praena B, Bello-Morales R, Saiz JC, López-Guerrero JA, Tabarés E, Sobrino F. Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP. J Clin Med. 2019 Sep 11;8(9). doi: 10.3390/jcm8091442. PMID: 31514402; PMCID: PMC6780826.
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J Clin Med. 2019 Sep 11;8(9). doi: 10.3390/jcm8091442.

Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP.

Journal of clinical medicine

Miguel Gil, Rocío González-González, Angela Vázquez-Calvo, Arturo Álvarez-Gutiérrez, Miguel A Martín-Acebes, Beatriz Praena, Raquel Bello-Morales, Juan-Carlos Saiz, Jose A López-Guerrero, Enrique Tabarés, Francisco Sobrino

Affiliations

  1. BIFAP, Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Agency for Medicines and Medical Devices (AEMPS), 28022 Madrid, Spain. [email protected].
  2. BIFAP, Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Agency for Medicines and Medical Devices (AEMPS), 28022 Madrid, Spain. [email protected].
  3. Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Nicolás Cabrera 1, 28049 Madrid, Spain. [email protected].
  4. BIFAP, Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Agency for Medicines and Medical Devices (AEMPS), 28022 Madrid, Spain. [email protected].
  5. Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INA), 28040 Madrid, Spain. [email protected].
  6. Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Nicolás Cabrera 1, 28049 Madrid, Spain. [email protected].
  7. Universidad Autónoma de Madrid, Departamento de Biología Molecular, Edificio de. Biología, Darwin 2, Cantoblanco, 28049 Madrid, Spain. [email protected].
  8. Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Nicolás Cabrera 1, 28049 Madrid, Spain. [email protected].
  9. Universidad Autónoma de Madrid, Departamento de Biología Molecular, Edificio de. Biología, Darwin 2, Cantoblanco, 28049 Madrid, Spain. [email protected].
  10. Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INA), 28040 Madrid, Spain. [email protected].
  11. Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Nicolás Cabrera 1, 28049 Madrid, Spain. [email protected].
  12. Universidad Autónoma de Madrid, Departamento de Biología Molecular, Edificio de. Biología, Darwin 2, Cantoblanco, 28049 Madrid, Spain. [email protected].
  13. Universidad Autónoma de Madrid, Facultad de Medicina, Arzobispo Morcillo 4, 28029 Madrid, Spain. [email protected].
  14. Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Nicolás Cabrera 1, 28049 Madrid, Spain. [email protected].

PMID: 31514402 PMCID: PMC6780826 DOI: 10.3390/jcm8091442

Abstract

The objective of this study is to evaluate the risk of clinical infections by herpesviruses in patients exposed to valproic acid (VPA). We performed a case-control study nested in a primary cohort selected from the Spanish primary care population-based research database BIFAP (Base de datos para la Investigación Farmacoepidemiológica en Atención Primaria) over the period 2001-2015. The events of interest were those diseases caused by any herpesviruses known to infect humans. For each case, up to 10 controls per case matched by age, gender, and calendar date were randomly selected. A conditional logistic regression was used to compute adjusted odds ratios (OR) and their 95% confidence intervals (95% CI). Current use of VPA was associated with a trend towards a reduced risk of clinical infections by herpesviruses as compared with non-users (OR 0.84; CI 95% 0.7-1.0;

Keywords: BIFAP; case-control study; electronic health care database; herpesvirus infections; valproic acid

Conflict of interest statement

The authors declare no conflict of interest.

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