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Manetti M, Romano E, Rosa I, et al. Systemic Sclerosis Serum Steers the Differentiation of Adipose-Derived Stem Cells Toward Profibrotic Myofibroblasts: Pathophysiologic Implications. J Clin Med. 2019;8(8)doi: 10.3390/jcm8081256.
Manetti, M., Romano, E., Rosa, I., Fioretto, B. S., Praino, E., Guiducci, S., Iannone, F., Ibba-Manneschi, L., & Matucci-Cerinic, M. (2019). Systemic Sclerosis Serum Steers the Differentiation of Adipose-Derived Stem Cells Toward Profibrotic Myofibroblasts: Pathophysiologic Implications. Journal of clinical medicine, 8(8), . https://doi.org/10.3390/jcm8081256
Manetti, Mirko, et al. "Systemic Sclerosis Serum Steers the Differentiation of Adipose-Derived Stem Cells Toward Profibrotic Myofibroblasts: Pathophysiologic Implications." Journal of clinical medicine vol. 8,8 (2019). doi: https://doi.org/10.3390/jcm8081256
Manetti M, Romano E, Rosa I, Fioretto BS, Praino E, Guiducci S, Iannone F, Ibba-Manneschi L, Matucci-Cerinic M. Systemic Sclerosis Serum Steers the Differentiation of Adipose-Derived Stem Cells Toward Profibrotic Myofibroblasts: Pathophysiologic Implications. J Clin Med. 2019 Aug 19;8(8). doi: 10.3390/jcm8081256. PMID: 31430950; PMCID: PMC6723717.
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J Clin Med. 2019 Aug 19;8(8). doi: 10.3390/jcm8081256.

Systemic Sclerosis Serum Steers the Differentiation of Adipose-Derived Stem Cells Toward Profibrotic Myofibroblasts: Pathophysiologic Implications.

Journal of clinical medicine

Mirko Manetti, Eloisa Romano, Irene Rosa, Bianca Saveria Fioretto, Emanuela Praino, Serena Guiducci, Florenzo Iannone, Lidia Ibba-Manneschi, Marco Matucci-Cerinic

Affiliations

  1. Section of Anatomy and Histology, Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy. [email protected].
  2. Division of Rheumatology and Scleroderma Unit, AOUC, Department of Geriatric Medicine, Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
  3. Section of Anatomy and Histology, Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
  4. Rheumatology Unit, Department of Emergency and Organ Transplantation, University of Bari, 70121 Bari, Italy.

PMID: 31430950 PMCID: PMC6723717 DOI: 10.3390/jcm8081256

Abstract

Systemic sclerosis (SSc; scleroderma) is characterized by life-threatening progressive multiorgan fibrosis orchestrated by profibrotic myofibroblasts originating from different sources. Because recent data demonstrated that the majority of myofibroblasts in a murine scleroderma model arise from adipocytic progenitors through the adipocyte-myofibroblast transition process, we sought to determine whether the SSc microenvironment may affect the differentiation potential of adipose-derived stem cells (ADSC). Normal human ADSC from three donors were treated with serum from SSc patients (

Keywords: adipose-derived stem cells; fibrosis; myofibroblastic differentiation; myofibroblasts; scleroderma; systemic sclerosis

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