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Thekkinghat AA, Yadav KK, Rangarajan PN. Apolipoprotein L9 interacts with LC3/GABARAP and is a microtubule-associated protein with a widespread subcellular distribution. Biol Open. 2019;8(9)doi: 10.1242/bio.045930.
Thekkinghat, A. A., Yadav, K. K., & Rangarajan, P. N. (2019). Apolipoprotein L9 interacts with LC3/GABARAP and is a microtubule-associated protein with a widespread subcellular distribution. Biology open, 8(9), . https://doi.org/10.1242/bio.045930
Thekkinghat, Arvind A, et al. "Apolipoprotein L9 interacts with LC3/GABARAP and is a microtubule-associated protein with a widespread subcellular distribution." Biology open vol. 8,9 (2019). doi: https://doi.org/10.1242/bio.045930
Thekkinghat AA, Yadav KK, Rangarajan PN. Apolipoprotein L9 interacts with LC3/GABARAP and is a microtubule-associated protein with a widespread subcellular distribution. Biol Open. 2019 Sep 25;8(9). doi: 10.1242/bio.045930. PMID: 31515254; PMCID: PMC6777357.
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Biol Open. 2019 Sep 25;8(9). doi: 10.1242/bio.045930.

Apolipoprotein L9 interacts with LC3/GABARAP and is a microtubule-associated protein with a widespread subcellular distribution.

Biology open

Arvind A Thekkinghat, Kamlesh K Yadav, Pundi N Rangarajan

Affiliations

  1. Department of Biochemistry, Indian Institute of Science, Bangalore, 560012, India [email protected] [email protected].
  2. Department of Biochemistry, Indian Institute of Science, Bangalore, 560012, India.

PMID: 31515254 PMCID: PMC6777357 DOI: 10.1242/bio.045930

Abstract

Mouse Apolipoprotein L9 is a 34-kDa phosphatidylethanolamine (PE)-binding protein. The gene is present only in mouse and rat genomes; hence it is restricted to two species. To understand why, it is essential to uncover details about its functions in cellular processes. Here we show that ApoL9 interacts with the proteins of the LC3 and GABARAP subfamilies, which are key players in macroautophagy.

© 2019. Published by The Company of Biologists Ltd.

Keywords: Autophagy adaptor; Extracellular mitochondria; Lipid-binding protein; Lipidated LC3; Lysosomal localization; Phosphatidylethanolamine-binding

Conflict of interest statement

Competing interestsThe authors declare no competing or financial interests.

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