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Worth C, Yusuf IH, Turner B, et al. An audit of the use of hydroxychloroquine in rheumatology clinics. Rheumatol Adv Pract. 2018;2(1):rky013doi: 10.1093/rap/rky013.
Worth, C., Yusuf, I. H., Turner, B., Gourier, H., Brooks, E. E., Mort, D. O., Sharma, S., Downes, S. M., & Luqmani, R. A. (2018). An audit of the use of hydroxychloroquine in rheumatology clinics. Rheumatology advances in practice, 2(1), rky013. https://doi.org/10.1093/rap/rky013
Worth, Claudia, et al. "An audit of the use of hydroxychloroquine in rheumatology clinics." Rheumatology advances in practice vol. 2,1 (2018): rky013. doi: https://doi.org/10.1093/rap/rky013
Worth C, Yusuf IH, Turner B, Gourier H, Brooks EE, Mort DO, Sharma S, Downes SM, Luqmani RA. An audit of the use of hydroxychloroquine in rheumatology clinics. Rheumatol Adv Pract. 2018 May 08;2(1):rky013. doi: 10.1093/rap/rky013. eCollection 2018. PMID: 31431961; PMCID: PMC6649984.
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Rheumatol Adv Pract. 2018 May 08;2(1):rky013. doi: 10.1093/rap/rky013. eCollection 2018.

An audit of the use of hydroxychloroquine in rheumatology clinics.

Rheumatology advances in practice

Claudia Worth, Imran H Yusuf, Bethany Turner, Hanae Gourier, Emma E Brooks, Daniel O Mort, Srilakshmi Sharma, Susan M Downes, Raashid A Luqmani

Affiliations

  1. Department of Rheumatology, Oxford University Hospitals, Oxford.
  2. Oxford Eye Hospital, Oxford University Hospitals, Oxford.
  3. Department of Emergency Medicine, Stoke Mandeville Hospital, Aylesbury.
  4. School of Medicine, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK.
  5. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK.

PMID: 31431961 PMCID: PMC6649984 DOI: 10.1093/rap/rky013

Abstract

OBJECTIVE: The aim was to audit the use, indications, complications and patient information regarding HCQ treatment in rheumatology clinics in a tertiary referral centre.

METHODS: During a 9-month period, we identified all patients prescribed HCQ and attending rheumatology clinics in one hospital. We established: (i) the indication for HCQ; (ii) the prevalence of HCQ overdosing based on absolute body weight (ABW); (iii) documentation of warning of risk of retinal toxicity; (iv) systemic and ocular co-morbidities; (v) ocular symptoms during treatment; and (vi) reasons for stopping HCQ.

RESULTS: We identified 427 patients (104 male and 323 female). The cumulative dose of HCQ was lower in RA (median 365 g; range 6-1752 g) compared with SLE (450 g; 66-1788 g) (

CONCLUSION: HCQ therapy is being used for >5 years in 29% of patients with rheumatic diseases, with higher than recommended doses in ∼10% of patients. We recommend more rigorous scrutiny of the use of HCQ to reduce the risk of retinopathy.

Keywords: hydroxychloroquine; ophthalmological screening; retinal toxicity; rheumatoid arthritis; systemic lupus erythematosus

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