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Gongalsky M, Gvindzhiliia G, Tamarov K, et al. Radiofrequency Hyperthermia of Cancer Cells Enhanced by Silicic Acid Ions Released During the Biodegradation of Porous Silicon Nanowires. ACS Omega. 2019;4(6):10662-10669doi: 10.1021/acsomega.9b01030.
Gongalsky, M., Gvindzhiliia, G., Tamarov, K., Shalygina, O., Pavlikov, A., Solovyev, V., Kudryavtsev, A., Sivakov, V., & Osminkina, L. A. (2019). Radiofrequency Hyperthermia of Cancer Cells Enhanced by Silicic Acid Ions Released During the Biodegradation of Porous Silicon Nanowires. ACS omega, 4(6), 10662-10669. https://doi.org/10.1021/acsomega.9b01030
Gongalsky, Maxim, et al. "Radiofrequency Hyperthermia of Cancer Cells Enhanced by Silicic Acid Ions Released During the Biodegradation of Porous Silicon Nanowires." ACS omega vol. 4,6 (2019): 10662-10669. doi: https://doi.org/10.1021/acsomega.9b01030
Gongalsky M, Gvindzhiliia G, Tamarov K, Shalygina O, Pavlikov A, Solovyev V, Kudryavtsev A, Sivakov V, Osminkina LA. Radiofrequency Hyperthermia of Cancer Cells Enhanced by Silicic Acid Ions Released During the Biodegradation of Porous Silicon Nanowires. ACS Omega. 2019 Jun 19;4(6):10662-10669. doi: 10.1021/acsomega.9b01030. eCollection 2019 Jun 30. PMID: 31460163; PMCID: PMC6648043.
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ACS Omega. 2019 Jun 19;4(6):10662-10669. doi: 10.1021/acsomega.9b01030. eCollection 2019 Jun 30.

Radiofrequency Hyperthermia of Cancer Cells Enhanced by Silicic Acid Ions Released During the Biodegradation of Porous Silicon Nanowires.

ACS omega

Maxim Gongalsky, Georgii Gvindzhiliia, Konstantin Tamarov, Olga Shalygina, Alexander Pavlikov, Valery Solovyev, Andrey Kudryavtsev, Vladimir Sivakov, Liubov A Osminkina

Affiliations

  1. Department of Physics, Lomonosov Moscow State University, Leninskie Gory 1, 119991 Moscow, Russia.
  2. University of Eastern Finland - Kuopio Campus, Yliopistonranta 1, 70210 Kuopio, Finland.
  3. Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Pushchino, 142290 Moscow Region, Russia.
  4. Leibniz Institute of Photonic Technology, Jena 07745, Germany.
  5. Institute for Biological Instrumentation of Russian Academy of Sciences, Pushchino 142290, Russia.

PMID: 31460163 PMCID: PMC6648043 DOI: 10.1021/acsomega.9b01030

Abstract

The radiofrequency (RF) mild hyperthermia effect sensitized by biodegradable nanoparticles is a promising approach for therapy and diagnostics of numerous human diseases including cancer. Herein, we report the significant enhancement of local destruction of cancer cells induced by RF hyperthermia in the presence of degraded low-toxic porous silicon (PSi) nanowires (NWs). Proper selection of RF irradiation time (10 min), intensity, concentration of PSi NWs, and incubation time (24 h) decreased cell viability to 10%, which can be potentially used for cancer treatment. The incubation for 24 h is critical for degradation of PSi NWs and the formation of silicic acid ions H

Conflict of interest statement

The authors declare no competing financial interest.

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