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Al-Kuraishy HM, Al-Gareeb AI, Al-Nami MS. Vinpocetine Improves Oxidative Stress and Pro-Inflammatory Mediators in Acute Kidney Injury. Int J Prev Med. 2019;10:142doi: 10.4103/ijpvm.IJPVM_5_19.
Al-Kuraishy, H. M., Al-Gareeb, A. I., & Al-Nami, M. S. (2019). Vinpocetine Improves Oxidative Stress and Pro-Inflammatory Mediators in Acute Kidney Injury. International journal of preventive medicine, 10142. https://doi.org/10.4103/ijpvm.IJPVM_5_19
Al-Kuraishy, Hayder M, et al. "Vinpocetine Improves Oxidative Stress and Pro-Inflammatory Mediators in Acute Kidney Injury." International journal of preventive medicine vol. 10 (2019): 142. doi: https://doi.org/10.4103/ijpvm.IJPVM_5_19
Al-Kuraishy HM, Al-Gareeb AI, Al-Nami MS. Vinpocetine Improves Oxidative Stress and Pro-Inflammatory Mediators in Acute Kidney Injury. Int J Prev Med. 2019 Aug 12;10:142. doi: 10.4103/ijpvm.IJPVM_5_19. eCollection 2019. PMID: 31516683; PMCID: PMC6710925.
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Int J Prev Med. 2019 Aug 12;10:142. doi: 10.4103/ijpvm.IJPVM_5_19. eCollection 2019.

Vinpocetine Improves Oxidative Stress and Pro-Inflammatory Mediators in Acute Kidney Injury.

International journal of preventive medicine

Hayder M Al-Kuraishy, Ali I Al-Gareeb, Marwa S Al-Nami

Affiliations

  1. Department of Pharmacology, Toxicology and Medicine, College of Medicine, Almustansiriya University, Baghdad, Iraq.

PMID: 31516683 PMCID: PMC6710925 DOI: 10.4103/ijpvm.IJPVM_5_19

Abstract

BACKGROUND: Gentamicin-induced-acute kidney injury (AKI) is a multifaceted phenomenon which previously linked to the oxidative stress only. Vinpocetine prevents reactive free radical generation which contributed in reduction of damage. Therefore, objective of the present study was to investigate the renoprotective effect of vinpocetine on gentamicin-induced-AKI in rats.

METHODS: Thirty Sprague Dawley Male rat were divided into three groups. Control group (

RESULTS: Vinpocetine led to significant renoprotective effect on gentamicin induced-AKI through amelioration of blood urea and serum creatinine compared with gentamicin group

CONCLUSIONS: Vinpocetine leads to significant attenuation of gentamicin-induced-AKI through modulation of oxidative stress and pro-inflammatory pathway.

Keywords: AKI; gentamicins; oxidative stresses; pro-inflammatory pathways; vinpocetines

Conflict of interest statement

There are no conflicts of interest.

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