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Eruysal E, Ravdin L, Kamel H, et al. Plasma lipocalin-2 levels in the preclinical stage of Alzheimer's disease. Alzheimers Dement (Amst). 2019;11:646-653doi: 10.1016/j.dadm.2019.07.004.
Eruysal, E., Ravdin, L., Kamel, H., Iadecola, C., & Ishii, M. (2019). Plasma lipocalin-2 levels in the preclinical stage of Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands), 11646-653. https://doi.org/10.1016/j.dadm.2019.07.004
Eruysal, Emily, et al. "Plasma lipocalin-2 levels in the preclinical stage of Alzheimer's disease." Alzheimer's & dementia (Amsterdam, Netherlands) vol. 11 (2019): 646-653. doi: https://doi.org/10.1016/j.dadm.2019.07.004
Eruysal E, Ravdin L, Kamel H, Iadecola C, Ishii M. Plasma lipocalin-2 levels in the preclinical stage of Alzheimer's disease. Alzheimers Dement (Amst). 2019 Sep 06;11:646-653. doi: 10.1016/j.dadm.2019.07.004. eCollection 2019 Dec. PMID: 31517027; PMCID: PMC6733778.
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Alzheimers Dement (Amst). 2019 Sep 06;11:646-653. doi: 10.1016/j.dadm.2019.07.004. eCollection 2019 Dec.

Plasma lipocalin-2 levels in the preclinical stage of Alzheimer's disease.

Alzheimer's & dementia (Amsterdam, Netherlands)

Emily Eruysal, Lisa Ravdin, Hooman Kamel, Costantino Iadecola, Makoto Ishii

Affiliations

  1. Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
  2. Department of Neurology, Weill Cornell Medicine, New York, NY, USA.

PMID: 31517027 PMCID: PMC6733778 DOI: 10.1016/j.dadm.2019.07.004

Abstract

INTRODUCTION: Lipocalin-2 is an acute-phase protein with pleotropic functions that has been implicated in several diseases including Alzheimer's disease (AD). However, it is unknown if circulating lipocalin-2 levels are altered in the preclinical stage of AD, where AD pathology has accumulated but cognition remains relatively intact.

METHODS: In this cross-sectional study, we used an immunoassay to measure plasma lipocalin-2 levels in cognitively normal (Clinical Dementia Rating 0) elderly individuals. 38 of 156 subjects were classified as preclinical AD by cerebrospinal fluid criteria.

RESULTS: Plasma lipocalin-2 levels were higher in preclinical AD compared with control subjects and associated with cerebrospinal fluid amyloid-beta

DISCUSSION: Collectively, these results raise the possibility that circulating lipocalin-2 is involved early in AD pathogenesis and may represent an early blood biomarker of amyloid-beta pathology.

Keywords: Alzheimer's disease; Amyloid beta-Peptides; Biomarkers; Blood; Dementia; Immunoassay; Lipocalin; NGAL; Preclinical

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