Display options
Share it on

Cureus. 2019 Aug 21;11(8):e5449. doi: 10.7759/cureus.5449.

Simple Reason for Hypoglycemia: ACE Inhibitor-induced Severe Recurrent Hypoglycemia in a Nondiabetic Patient.

Cureus

Ghada Elshimy, Pawarid Techathaveewat, Mahmoud Alsayed, Sathya Jyothinagaram, Ricardo Correa

Affiliations

  1. Endocrinology, Diabetes and Metabolism, University of Arizona College of Medicine-Phoenix, Phoenix, USA.

PMID: 31489273 PMCID: PMC6713252 DOI: 10.7759/cureus.5449

Abstract

Angiotensin-converting enzyme (ACE) inhibitors are among the most common medications used to treat patients with concomitant diabetes and hypertension. They are considered the first line of treatment for hypertension in this population. Several case studies have reported that ACE inhibitors can induce hypoglycemia in patients with diabetes. To our knowledge, however, ACE inhibitors have not been found to induce hypoglycemia in patients without diabetes. This report describes a patient without diabetes experiencing recurrent severe hypoglycemia induced by the ACE inhibitor lisinopril.

Keywords: ace inhibitors; hypertension; hypoglycemia; lisinopril

Conflict of interest statement

The authors have declared that no competing interests exist.

References

  1. Hypertension. 2001 Dec 1;38(6):1355-60 - PubMed
  2. Am J Hypertens. 1992 Jun;5(6 Pt 1):361-5 - PubMed
  3. Br J Clin Pharmacol. 2008 Jul;66(1):142-5 - PubMed
  4. J Clin Endocrinol Metab. 2009 Mar;94(3):709-28 - PubMed
  5. Nephron. 1991;59(2):341-2 - PubMed
  6. J Intern Med Suppl. 1991;735:119-25 - PubMed
  7. Lancet. 1986 May 3;1(8488):1035 - PubMed
  8. Postgrad Med J. 1986;62 Suppl 1:59-64 - PubMed
  9. N Engl J Med. 1988 Dec 15;319(24):1609 - PubMed
  10. Ann Intern Med. 1985 Jan;102(1):134-5 - PubMed
  11. Lancet. 1995 May 13;345(8959):1195-8 - PubMed
  12. Intern Med. 1997 Jan;36(1):77 - PubMed
  13. Diabetes Care. 1997 Sep;20(9):1363-7 - PubMed

Publication Types