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Slavin TP, Weitzel JN, Neuhausen SL, et al. Genetics of gastric cancer: what do we know about the genetic risks?. Transl Gastroenterol Hepatol. 2019;4:55doi: 10.21037/tgh.2019.07.02.
Slavin, T. P., Weitzel, J. N., Neuhausen, S. L., Schrader, K. A., Oliveira, C., & Karam, R. (2019). Genetics of gastric cancer: what do we know about the genetic risks?. Translational gastroenterology and hepatology, 455. https://doi.org/10.21037/tgh.2019.07.02
Slavin, Thomas Paul, et al. "Genetics of gastric cancer: what do we know about the genetic risks?." Translational gastroenterology and hepatology vol. 4 (2019): 55. doi: https://doi.org/10.21037/tgh.2019.07.02
Slavin TP, Weitzel JN, Neuhausen SL, Schrader KA, Oliveira C, Karam R. Genetics of gastric cancer: what do we know about the genetic risks?. Transl Gastroenterol Hepatol. 2019 Jul 29;4:55. doi: 10.21037/tgh.2019.07.02. eCollection 2019. PMID: 31463414; PMCID: PMC6691077.
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Transl Gastroenterol Hepatol. 2019 Jul 29;4:55. doi: 10.21037/tgh.2019.07.02. eCollection 2019.

Genetics of gastric cancer: what do we know about the genetic risks?.

Translational gastroenterology and hepatology

Thomas Paul Slavin, Jeffrey N Weitzel, Susan L Neuhausen, Kasmintan A Schrader, Carla Oliveira, Rachid Karam

Affiliations

  1. Division of Clinical Cancer Genomics, Department of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA, USA.
  2. Department of Population Sciences, City of Hope, Duarte, CA, USA.
  3. Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal.
  4. Department of Molecular Oncology, BC Cancer, Vancouver, BC, Canada.
  5. Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
  6. Ambry Genetics Laboratories, Aliso Viejo, CA, USA.
  7. i3S, Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.
  8. IPATIMUP, Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.

PMID: 31463414 PMCID: PMC6691077 DOI: 10.21037/tgh.2019.07.02

Abstract

An appreciable number of patients with gastric cancer have an underlying hereditary cancer susceptibility syndrome as the cause of their gastric cancer, particularly those with early onset gastric cancer or a family history of gastric or other cancers. Pathogenic germline variants in specific genes account for the known gastric cancer predisposition syndromes. Germline genetic testing can identify individuals and their family members who carry inherited pathogenic gene variants, and thus have increased risk of developing gastric or other cancers. Ideally, germline pathogenic variants can be identified in family members before the onset of disease, when early detection or prevention strategies can be implemented most effectively to decrease gastric cancer- related morbidity and mortality. This article reviews some of the currently known gastric cancer predisposition syndromes and their associated cancer risks. We also discuss current research and advances in the field of genetic gastric cancer susceptibility.

Keywords: Stomach neoplasms; cadherins; gastric cancer; genetic predisposition to disease; genetic testing; hereditary nonpolyposis

Conflict of interest statement

Conflict of Interest: R Karam was an employee of Ambry Genetics during the preparation of this manuscript. The other authors have no conflicts of interest to declare.

References

  1. J Med Genet. 1999 Dec;36(12):873-80 - PubMed
  2. Hum Mol Genet. 2009 May 1;18(9):1545-55 - PubMed
  3. Lancet. 2010 Jul 24;376(9737):245-51 - PubMed
  4. J Oncol Pract. 2011 Jan;7(1):39-42 - PubMed
  5. CA Cancer J Clin. 2011 Sep-Oct;61(5):327-59 - PubMed
  6. J Pathol. 2013 Mar;229(4):621-9 - PubMed
  7. Arch Iran Med. 2013 Jun;16(6):358-65 - PubMed
  8. Lancet Oncol. 2015 Feb;16(2):e60-70 - PubMed
  9. Gut. 2015 Aug;64(8):1209-19 - PubMed
  10. Genet Med. 2015 May;17(5):405-24 - PubMed
  11. J Med Genet. 2015 Jun;52(6):361-74 - PubMed
  12. N Engl J Med. 2015 Jun 25;372(26):2509-20 - PubMed
  13. JAMA Oncol. 2015 Apr;1(1):23-32 - PubMed
  14. Surg Oncol Clin N Am. 2015 Oct;24(4):765-77 - PubMed
  15. JAMA Oncol. 2016 Jan;2(1):104-11 - PubMed
  16. Am J Hum Genet. 2016 May 5;98(5):830-842 - PubMed
  17. Gastrointest Endosc. 2018 Feb;87(2):408-418 - PubMed
  18. Cancer Genet. 2017 Oct;216-217:111-119 - PubMed
  19. Lancet Gastroenterol Hepatol. 2018 Jul;3(7):489-498 - PubMed
  20. J Med Genet. 2018 Jul;55(7):431-441 - PubMed
  21. Nat Med. 2018 Sep;24(9):1449-1458 - PubMed
  22. Nat Genet. 2018 Sep;50(9):1219-1224 - PubMed
  23. Hum Mutat. 2018 Nov;39(11):1553-1568 - PubMed
  24. J Clin Oncol. 2018 Oct 19;:JCO1800328 - PubMed
  25. Gastric Cancer. 2019 Jul;22(4):899-903 - PubMed
  26. Nature. 1998 Mar 26;392(6674):402-5 - PubMed

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