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Lobzhanidze G, Lordkipanidze T, Zhvania M, et al. Effect of propionic acid on the morphology of the amygdala in adolescent male rats and their behavior. Micron. 2019;125:102732doi: 10.1016/j.micron.2019.102732.
Lobzhanidze, G., Lordkipanidze, T., Zhvania, M., Japaridze, N., MacFabe, D. F., Pochkidze, N., Gasimov, E., & Rzaev, F. (2019). Effect of propionic acid on the morphology of the amygdala in adolescent male rats and their behavior. Micron (Oxford, England : 1993), 125102732. https://doi.org/10.1016/j.micron.2019.102732
Lobzhanidze, Giorgi, et al. "Effect of propionic acid on the morphology of the amygdala in adolescent male rats and their behavior." Micron (Oxford, England : 1993) vol. 125 (2019): 102732. doi: https://doi.org/10.1016/j.micron.2019.102732
Lobzhanidze G, Lordkipanidze T, Zhvania M, Japaridze N, MacFabe DF, Pochkidze N, Gasimov E, Rzaev F. Effect of propionic acid on the morphology of the amygdala in adolescent male rats and their behavior. Micron. 2019 Oct;125:102732. doi: 10.1016/j.micron.2019.102732. Epub 2019 Aug 06. PMID: 31437571.
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Micron. 2019 Oct;125:102732. doi: 10.1016/j.micron.2019.102732. Epub 2019 Aug 06.

Effect of propionic acid on the morphology of the amygdala in adolescent male rats and their behavior.

Micron (Oxford, England : 1993)

Giorgi Lobzhanidze, Tamar Lordkipanidze, Mzia Zhvania, Nadezhda Japaridze, Derrick Fraser MacFabe, Nino Pochkidze, Eldar Gasimov, Fuad Rzaev

Affiliations

  1. School of Natural Sciences and Medicine, Ilia State University, 3/5 K. Cholokashvili venue, 0162 Tbilisi, Georgia; Department of Brain Ultrastructure and Nanoarchitecture. I. Beritashvili Center of Experimental Biomedicine. 14 Gotua Street, 0160 Tbilisi, Georgia.
  2. School of Natural Sciences and Medicine, Ilia State University, 3/5 K. Cholokashvili venue, 0162 Tbilisi, Georgia; Department of Brain Ultrastructure and Nanoarchitecture. I. Beritashvili Center of Experimental Biomedicine. 14 Gotua Street, 0160 Tbilisi, Georgia. Electronic address: [email protected].
  3. Department of Brain Ultrastructure and Nanoarchitecture. I. Beritashvili Center of Experimental Biomedicine. 14 Gotua Street, 0160 Tbilisi, Georgia; New Vision University, 1A EvgeniMikeladze Street, 0159 Tbilisi, Georgia.
  4. Kilee Patchell-Evans Autism Research Group, London, Canada; Maastricht University, Netherlands.
  5. Azerbaijan Medical University, 23 Bakikhanov Street, 1022 Baku, Azerbaijan.

PMID: 31437571 DOI: 10.1016/j.micron.2019.102732

Abstract

Autism spectrum disorder is a group of life-long developmental syndromes, characterized by stereotypic behavior, restricted, communication deficits, cognitive and social impairments. Autism spectrum disorder is heritable state, provided by the mutations of well-conserved genes; however, it has been increasingly accepted, that most of such states are the result of complex interaction between individual's genetic profile and the environment that he/she is exposed to. Gut microbiota plays one of the central roles in the etiology of autism. Propionic acid is one of the most abundant short-chain fatty acids, made by enteric bacteria. Propionic acid has many positive functions and acts as the main mediator between nutrition, gut microbiota and brain physiology. However, increased level of propionic acid is associated with various neurological pathologies, including autism. It is proposed that some types of autism might be partially related with alterations in propionic acid metabolism. The amygdala, the main component of social brain, via its large interconnections with fronto-limbic neural system, plays one of the key roles in social communications, emotional memory and emotional processing. Social behavior is a hot topic in autism research. As to anxiety, it is not the main characteristics of ASD, but represents one of the most common its co morbidities. Several theoretical reasons compatible with amygdala dysfunction have been suggested to account for socio-emotional disturbances in autism. In the present study, using adolescent male Wistar rats, the effect of acute administration of low dose of propionic acid on social behavior, anxiety-like behavior and the structure/ultrastructure of central nucleus of amygdale was described. In addition to qualitative analysis, on electron microscopic level the quantitative analysis of some parameters of synapses was performed. Behavior was assessed 2, 24 and 48 hours after treatment. The results revealed that even single and relatively low dose of propionic acid is sufficient to produce fast and relatively long lasting (48 h after treatment) decrease of social motivation, whereas asocial motivation and emotional sphere remain unaffected. Morphological analyses of propionic acid-treated brain revealed the reduced neuron number and the increase of the number of glial cells. Electron microscopically, in some neurons the signs of apoptosis and chromatolysis were detected. Glial alterations were more common. Particularly, the activation of astrocytes and microglia were often observed. Pericapillary glia was the most changed. Neuronal, glial and presynaptic mitochondria showed substantial structural diversities, mainly in terms of size and form. Total number of the area of presynaptic profile was significantly decreased. Some axons were moderately demyelinated. In general, the data indicate that even low dose of propionic acid produces in adolescent rodents immediate changes in social behavior, and structural/ultrastructural alterations in amygdala. Ultrastructural alterations may reflect moderate modifications in functional networks of social brain.

Copyright © 2019 Elsevier Ltd. All rights reserved.

Keywords: Amygdala’s structure/ultrastructure; Anxiety-like behavior; Propionic acid; Rat; Social behavior

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