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Zohoun A, Baglo Agbodande T, Zohoun L, et al. Prevalence of hemoglobin abnormalities in an apparently healthy population in Benin. Hematol Transfus Cell Ther. 2019;42(2):145-149doi: 10.1016/j.htct.2019.06.005.
Zohoun, A., Baglo Agbodande, T., Zohoun, L., & Anani, L. (2020). Prevalence of hemoglobin abnormalities in an apparently healthy population in Benin. Hematology, transfusion and cell therapy, 42(2), 145-149. https://doi.org/10.1016/j.htct.2019.06.005
Zohoun, Alban, et al. "Prevalence of hemoglobin abnormalities in an apparently healthy population in Benin." Hematology, transfusion and cell therapy vol. 42,2 (2020): 145-149. doi: https://doi.org/10.1016/j.htct.2019.06.005
Zohoun A, Baglo Agbodande T, Zohoun L, Anani L. Prevalence of hemoglobin abnormalities in an apparently healthy population in Benin. Hematol Transfus Cell Ther. 2020 Apr - Jun;42(2):145-149. doi: 10.1016/j.htct.2019.06.005. Epub 2019 Sep 07. PMID: 31523029; PMCID: PMC7248501.
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Hematol Transfus Cell Ther. 2020 Apr - Jun;42(2):145-149. doi: 10.1016/j.htct.2019.06.005. Epub 2019 Sep 07.

Prevalence of hemoglobin abnormalities in an apparently healthy population in Benin.

Hematology, transfusion and cell therapy

Alban Zohoun, Tatiana Baglo Agbodande, Lutécia Zohoun, Ludovic Anani

Affiliations

  1. Faculté des Sciences de la Santé, Centre National Hospitalier Universitaire-Hubert Koutoukou Maga, Cotonou, Bénin; Hôpital d'Instruction des Armées de Cotonou, Centre Hospitalier Universitaire Cotonou, Bénin. Electronic address: [email protected].
  2. Faculté des Sciences de la Santé, Centre National Hospitalier Universitaire-Hubert Koutoukou Maga, Cotonou, Bénin.

PMID: 31523029 PMCID: PMC7248501 DOI: 10.1016/j.htct.2019.06.005

Abstract

BACKGROUND: Sickle cell disease is the most common monogenic disorder in humans and is a major public health concern in sub-Saharan Africa. In Benin, the prevalence of sickle cell disease is estimated to be 4.8%. Our study aimed to describe the prevalence of hemoglobin abnormalities in an apparently healthy Benin population.

METHODS: One thousand four hundred and eighty-three men and women, apparently in good health after medical screening, were tested for hemoglobin abnormalities by hemoglobin electrophoresis and the Emmel test. Subjects who were found to have homozygous or double heterozygous hemoglobin abnormalities, were re-sampled and a confirmation hemogram and hemoglobin electrophoresis test by capillary electrophoresis was performed.

RESULTS: Our study population was predominantly male (97.7%) with an average age of 21.3 years. 1390 subjects reported that they did not know their hemoglobin electrophoresis status. Hemoglobin electrophoresis profiles found were as follows: 1077 (72.6%) AA (normal), 238 (16.1%) AS, 161 (10.9%) AC, 3 (0.2%) SC, 4 (0.2%) CC and 0 (0%) SS. The 406 subjects with abnormal hemoglobin had balanced somatic growth, with general physical examination results showing no abnormalities. In the seven subjects with major sickle cell syndrome or hemoglobinosis (SC and CC), their values of various hemogram parameters were normal apart from the discreet presence of microcytic anemia.

CONCLUSION: Our study highlights the need for increased routine testing of hemoglobin abnormalities and newborn screening for sickle cell disease in order to enhance early disease detection, prevention and comprehensive care.

Copyright © 2019 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. All rights reserved.

Keywords: Benin; Hemoglobin electrophoresis; Newborn screening; Sickle cell disease

References

  1. Nat Rev Dis Primers. 2018 Mar 15;4:18010 - PubMed
  2. Haematologica. 2015 Apr;100(4):466-71 - PubMed
  3. Transfus Clin Biol. 2015 Jun;22(2):80-2 - PubMed
  4. J Clin Pathol. 2009 Jan;62(1):46-8 - PubMed
  5. Am J Hematol. 2018 Mar;93(3):363-370 - PubMed
  6. J Clin Pathol. 2009 Jan;62(1):39-41 - PubMed
  7. Ann Pediatr (Paris). 1985 Nov;32(9):780-9 - PubMed
  8. Semin Perinatol. 2015 Apr;39(3):238-51 - PubMed
  9. Pan Afr Med J. 2017 Jun 07;27:93 - PubMed
  10. Rev Epidemiol Sante Publique. 1999 Mar;47(1):29-36 - PubMed
  11. Med Sante Trop. 2012 Oct-Dec;22(4):390-3 - PubMed
  12. Front Pediatr. 2016 Feb 23;4:8 - PubMed
  13. Arch Pediatr. 2009 Apr;16(4):316-21 - PubMed
  14. Am J Hematol. 1998 Nov;59(3):208-13 - PubMed
  15. Tunis Med. 2017 Dec;95(12):229-233 - PubMed

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