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Stem Cells Int. 2019 Aug 05;2019:4149762. doi: 10.1155/2019/4149762. eCollection 2019.

The Antibiotic Bacitracin Protects Human Intestinal Epithelial Cells and Stem Cell-Derived Intestinal Organoids from .

Stem cells international

Ziyu Zhu, Leonie Schnell, Bastian Müller, Martin Müller, Panagiotis Papatheodorou, Holger Barth

Affiliations

  1. Institute of Pharmacology and Toxicology, University of Ulm Medical Center, 89081 Ulm, Germany.
  2. Department of Internal Medicine I, University of Ulm Medical Center, 89081 Ulm, Germany.

PMID: 31467562 PMCID: PMC6701344 DOI: 10.1155/2019/4149762

Abstract

Bacitracin is an established antibiotic for local application and inhibits the cell wall synthesis of Gram-positive bacteria. Recently, we discovered a completely different mode of action of bacitracin and reported that this drug protects human cells from intoxication by a variety of medically relevant bacterial protein toxins including CDT, the binary actin ADP-ribosylating toxin of

Conflict of interest statement

The authors declare that there are no conflicts of interest.

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