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Pharmaceuticals (Basel). 2019 Sep 16;12(3). doi: 10.3390/ph12030137.

Metal-Based Complexes as Pharmaceuticals for Molecular Imaging of the Liver.

Pharmaceuticals (Basel, Switzerland)

Julia Greiser, Wolfgang Weigand, Martin Freesmeyer

Affiliations

  1. University Hospital Jena, Clinic of Nuclear Medicine, Am Klinikum 1, 07747 Jena, Germany. [email protected].
  2. Institute for Inorganic and Analytical Chemistry, Friedrich Schiller University, Humboldtstrasse 8, 07743 Jena, Germany. [email protected].
  3. University Hospital Jena, Clinic of Nuclear Medicine, Am Klinikum 1, 07747 Jena, Germany. [email protected].

PMID: 31527492 PMCID: PMC6789861 DOI: 10.3390/ph12030137

Abstract

This article reviews the use of metal complexes as contrast agents (CA) and radiopharmaceuticals for the anatomical and functional imaging of the liver. The main focus was on two established imaging modalities: magnetic resonance imaging (MRI) and nuclear medicine, the latter including scintigraphy and positron emission tomography (PET). The review provides an overview on approved pharmaceuticals like Gd-based CA and

Keywords: MRI; PET; SPECT; contrast agents; diagnostics; liver; metal complexes; metals; molecular imaging; radiopharmaceuticals

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