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Da Rocha S, Bigot J, Onodi F, et al. Temporary Reduction of Membrane CD4 with the Antioxidant MnTBAP Is Sufficient to Prevent Immune Responses Induced by Gene Transfer. Mol Ther Methods Clin Dev. 2019;14:285-299doi: 10.1016/j.omtm.2019.06.011.
Da Rocha, S., Bigot, J., Onodi, F., Cosette, J., Corre, G., Poupiot, J., Fenard, D., Gjata, B., Galy, A., & Neildez-Nguyen, T. M. A. (2019). Temporary Reduction of Membrane CD4 with the Antioxidant MnTBAP Is Sufficient to Prevent Immune Responses Induced by Gene Transfer. Molecular therapy. Methods & clinical development, 14285-299. https://doi.org/10.1016/j.omtm.2019.06.011
Da Rocha, Sylvie, et al. "Temporary Reduction of Membrane CD4 with the Antioxidant MnTBAP Is Sufficient to Prevent Immune Responses Induced by Gene Transfer." Molecular therapy. Methods & clinical development vol. 14 (2019): 285-299. doi: https://doi.org/10.1016/j.omtm.2019.06.011
Da Rocha S, Bigot J, Onodi F, Cosette J, Corre G, Poupiot J, Fenard D, Gjata B, Galy A, Neildez-Nguyen TMA. Temporary Reduction of Membrane CD4 with the Antioxidant MnTBAP Is Sufficient to Prevent Immune Responses Induced by Gene Transfer. Mol Ther Methods Clin Dev. 2019 Jul 23;14:285-299. doi: 10.1016/j.omtm.2019.06.011. eCollection 2019 Sep 13. PMID: 31497619; PMCID: PMC6718808.
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Mol Ther Methods Clin Dev. 2019 Jul 23;14:285-299. doi: 10.1016/j.omtm.2019.06.011. eCollection 2019 Sep 13.

Temporary Reduction of Membrane CD4 with the Antioxidant MnTBAP Is Sufficient to Prevent Immune Responses Induced by Gene Transfer.

Molecular therapy. Methods & clinical development

Sylvie Da Rocha, Jérémy Bigot, Fanny Onodi, Jérémie Cosette, Guillaume Corre, Jérôme Poupiot, David Fenard, Bernard Gjata, Anne Galy, Thi My Anh Neildez-Nguyen

Affiliations

  1. Ecole Pratique des Hautes Etudes, PSL Research University, INTEGRARE UMR_S951, INSERM, Généthon, Univ-Evry, 91002 Evry, France.
  2. Généthon, UMR_S951, 91002 Evry, France.

PMID: 31497619 PMCID: PMC6718808 DOI: 10.1016/j.omtm.2019.06.011

Abstract

Unexpectedly, the synthetic antioxidant MnTBAP was found to cause a rapid and reversible downregulation of CD4 on T cells

Keywords: Immunomodulation; MnTBAP; antigen reexposure; gene transfer; gp120; membrane CD4 internalization; neutralizing antibodies; p56lck; rAAV capsid; redosing

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