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Albishtue AA, Yimer N, Zakaria MZA, et al. The role of edible bird's nest and mechanism of averting lead acetate toxicity effect on rat uterus. Vet World. 2019;12(7):1013-1021doi: 10.14202/vetworld.2019.1013-1021.
Albishtue, A. A., Yimer, N., Zakaria, M. Z. A., Haron, A. W., Babji, A. S., Abubakar, A. A., Baiee, F. H., Almhanna, H. K., & Almhanawi, B. H. (2019). The role of edible bird's nest and mechanism of averting lead acetate toxicity effect on rat uterus. Veterinary world, 12(7), 1013-1021. https://doi.org/10.14202/vetworld.2019.1013-1021
Albishtue, Abdulla A, et al. "The role of edible bird's nest and mechanism of averting lead acetate toxicity effect on rat uterus." Veterinary world vol. 12,7 (2019): 1013-1021. doi: https://doi.org/10.14202/vetworld.2019.1013-1021
Albishtue AA, Yimer N, Zakaria MZA, Haron AW, Babji AS, Abubakar AA, Baiee FH, Almhanna HK, Almhanawi BH. The role of edible bird's nest and mechanism of averting lead acetate toxicity effect on rat uterus. Vet World. 2019 Jul;12(7):1013-1021. doi: 10.14202/vetworld.2019.1013-1021. Epub 2019 Jul 12. PMID: 31528026; PMCID: PMC6702562.
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Vet World. 2019 Jul;12(7):1013-1021. doi: 10.14202/vetworld.2019.1013-1021. Epub 2019 Jul 12.

The role of edible bird's nest and mechanism of averting lead acetate toxicity effect on rat uterus.

Veterinary world

Abdulla A Albishtue, Nurhusien Yimer, Md Zuki A Zakaria, Abd Wahid Haron, Abd Salam Babji, Adamu A Abubakar, Falah H Baiee, Hazem Kareem Almhanna, Bahaa H Almhanawi

Affiliations

  1. Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
  2. Department of Anatomy and Histology, Faculty of Veterinary Medicine, University of Kufa, Najaf, Iraq.
  3. Department of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
  4. Innovation Centre for Confectionary Technology (MANIS), School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.
  5. Department of Companion Animal Medicine and Surgery, Faculty of Veterinary Medicine, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
  6. Department of Veterinary Surgery and Radiology, Usmanu Danfodiyo University, Sokoto, Nigeria.
  7. Department of Pathology, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

PMID: 31528026 PMCID: PMC6702562 DOI: 10.14202/vetworld.2019.1013-1021

Abstract

AIM: This study aimed to evaluate the protective effect of edible bird's nest (EBN) supplement on the uteri of rats exposed to lead acetate (LA) toxicity.

MATERIALS AND METHODS: Five treatment groups were established as follows: Group 1 (C), which was given distilled water; Group 2 (T0), which was administered with LA (10 mg/kg body weight [BW]); and Groups 3 (T1), 4 (T2), and 5 (T3), which were given LA (10 mg/kg BW) plus graded concentrations of 30, 60, and 120 mg/kg BW of EBN, respectively. Rats were euthanized at week 5 to collect blood for superoxide dismutase (SOD) assay, and uterus for histomorphological study and expression analyses of epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), and proliferating cell nuclear antigen (PCNA).

RESULTS: Results revealed that LA causes destruction of uterine lining cells and necrosis of uterine glands of exposed rats without EBN supplement while the degree of damage decreased among EBN treated groups; T3 showed the highest ameliorating effect against LA toxicity, as well as an increased number of uterine glands. Increased levels of SOD were also achieved in EBN supplemented groups than the controls. Results of immunohistochemistry showed significantly higher expressions of EGF, VEGF, and PCNA levels (p<0.05) in T3 compared to other treatments. EBN maintained upregulation of antioxidant - reactive oxygen species balance.

CONCLUSION: The findings showed that EBN could ameliorate the detrimental effects of LA toxicity on the uterus possibly by enhancing enzymatic antioxidant (SOD) activity as well as expressions of EGF, VEGF, and PCNA with cell proliferation roles.

Keywords: edible bird’s nest; growth factors; lead acetate; proliferating cell nuclear antigen; superoxide dismutase; uterus

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