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Beaulieu ME, Soucek L. Finding MYCure. Mol Cell Oncol. 2019;6(5):e1618178doi: 10.1080/23723556.2019.1618178.
Beaulieu, M. E., & Soucek, L. (2019). Finding MYCure. Molecular & cellular oncology, 6(5), e1618178. https://doi.org/10.1080/23723556.2019.1618178
Beaulieu, Marie-Eve, and Soucek, Laura. "Finding MYCure." Molecular & cellular oncology vol. 6,5 (2019): e1618178. doi: https://doi.org/10.1080/23723556.2019.1618178
Beaulieu ME, Soucek L. Finding MYCure. Mol Cell Oncol. 2019 Jun 20;6(5):e1618178. doi: 10.1080/23723556.2019.1618178. eCollection 2019. PMID: 31528695; PMCID: PMC6736125.
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Mol Cell Oncol. 2019 Jun 20;6(5):e1618178. doi: 10.1080/23723556.2019.1618178. eCollection 2019.

Finding MYCure.

Molecular & cellular oncology

Marie-Eve Beaulieu, Laura Soucek

Affiliations

  1. Peptomyc S.L., Edifici Cellex, Barcelona, Spain.
  2. Vall d'Hebron Institute of Oncology (VHIO), Edifici Cellex, Hospital Vall d'Hebron, Barcelona, Spain.
  3. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
  4. Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Bellaterra, Spain.

PMID: 31528695 PMCID: PMC6736125 DOI: 10.1080/23723556.2019.1618178

Abstract

Inhibiting the nuclear protein MYC involved in the majority of human cancers has long been considered an impossible mission and several technical challenges have discouraged the development of MYC inhibitory strategies. Nevertheless, in our recent publication in Science Translational Medicine "Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy", we demonstrate for the first time the feasibility of pharmacological MYC inhibition

Keywords: MYC; NSCLC; OMOMYC; mini-protein; peptide therapeutic

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