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Tryfidou DV, McClean C, Nikolaidis MG, et al. DNA Damage Following Acute Aerobic Exercise: A Systematic Review and Meta-analysis. Sports Med. 2020;50(1):103-127doi: 10.1007/s40279-019-01181-y.
Tryfidou, D. V., McClean, C., Nikolaidis, M. G., & Davison, G. W. (2020). DNA Damage Following Acute Aerobic Exercise: A Systematic Review and Meta-analysis. Sports medicine (Auckland, N.Z.), 50(1), 103-127. https://doi.org/10.1007/s40279-019-01181-y
Tryfidou, Despoina V, et al. "DNA Damage Following Acute Aerobic Exercise: A Systematic Review and Meta-analysis." Sports medicine (Auckland, N.Z.) vol. 50,1 (2020): 103-127. doi: https://doi.org/10.1007/s40279-019-01181-y
Tryfidou DV, McClean C, Nikolaidis MG, Davison GW. DNA Damage Following Acute Aerobic Exercise: A Systematic Review and Meta-analysis. Sports Med. 2020 Jan;50(1):103-127. doi: 10.1007/s40279-019-01181-y. PMID: 31529301; PMCID: PMC6942015.
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Sports Med. 2020 Jan;50(1):103-127. doi: 10.1007/s40279-019-01181-y.

DNA Damage Following Acute Aerobic Exercise: A Systematic Review and Meta-analysis.

Sports medicine (Auckland, N.Z.)

Despoina V Tryfidou, Conor McClean, Michalis G Nikolaidis, Gareth W Davison

Affiliations

  1. Sport and Exercise Sciences Research Institute, Ulster University, Shore Road, Newtownabbey, Northern Ireland, UK.
  2. Department of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Serres, Greece.
  3. Sport and Exercise Sciences Research Institute, Ulster University, Shore Road, Newtownabbey, Northern Ireland, UK. [email protected].

PMID: 31529301 PMCID: PMC6942015 DOI: 10.1007/s40279-019-01181-y

Abstract

BACKGROUND: Exercise is widely recognised for its health enhancing benefits. Despite this, an overproduction of reactive oxygen and nitrogen species (RONS), outstripping antioxidant defence mechanisms, can lead to a state of (chronic) oxidative stress. DNA is a vulnerable target of RONS attack and, if left unrepaired, DNA damage may cause genetic instability.

OBJECTIVE: This meta-analysis aimed to systematically investigate and assess the overall effect of studies reporting DNA damage following acute aerobic exercise.

METHODS: Web of Science, PubMed, MEDLINE, EMBASE, and Scopus were searched until April 2019. Outcomes included (1) multiple time-points (TPs) of measuring DNA damage post-exercise, (2) two different quantification methods (comet assay and 8-oxo-2'-deoxyguanosine; 8-OHdG), and (3) protocols of high intensity (≥ 75% of maximum rate of oxygen consumption; VO

RESULTS: Literature search identified 4316 non-duplicate records of which 35 studies were included in the meta-analysis. The evidence was strong, showcasing an increase in DNA damage immediately following acute aerobic exercise with a large-effect size at TP 0 (0 h) (SMD = 0.875; 95% CI 0.5, 1.25; p < 0.05). When comparing between comet assay and 8-OHdG at TP 0, a significant difference was observed only when using the comet assay. Finally, when isolating protocols of long-distance and high-intensity exercise, increased DNA damage was only observed in the latter. (SMD = 0.48; 95% CI - 0.16, 1.03; p = 0.15 and SMD = 1.18; 95% CI 0.71, 1.65; p < 0.05 respectively).

CONCLUSIONS: A substantial increase in DNA damage occurs immediately following acute aerobic exercise. This increase remains significant between 2 h and 1 day, but not within 5-28 days post-exercise. Such an increase was not observed in protocols of a long-distance. The relationship between exercise and DNA damage may be explained through the hormesis theory, which is somewhat one-dimensional, and thus limited. The hormesis theory describes how exercise modulates any advantageous or harmful effects mediated through RONS, by increasing DNA oxidation between the two end-points of the curve: physical inactivity and overtraining. We propose a more intricate approach to explain this relationship: a multi-dimensional model, to develop a better understanding of the complexity of the relationship between DNA integrity and exercise.

References

  1. Nutrients. 2019 Jun 15;11(6): - PubMed
  2. J Psychiatry Neurosci. 2015 Jan;40(1):3-4 - PubMed
  3. Nutr J. 2012 May 02;11:29 - PubMed
  4. Clin Chim Acta. 2016 Sep 1;460:146-51 - PubMed
  5. EMBO J. 2008 Feb 20;27(4):589-605 - PubMed
  6. Free Radic Biol Med. 2008 Jan 15;44(2):215-23 - PubMed
  7. World Allergy Organ J. 2012 Jan;5(1):9-19 - PubMed
  8. Int J Sport Nutr. 1993 Dec;3(4):356-75 - PubMed
  9. Am J Physiol Cell Physiol. 2009 Jan;296(1):C116-23 - PubMed
  10. Redox Rep. 2018 Dec;23(1):136-145 - PubMed
  11. Antioxidants (Basel). 2018 Jul 05;7(7):null - PubMed
  12. Int J Sports Med. 1996 Aug;17(6):397-403 - PubMed
  13. CMAJ. 2006 Mar 28;174(7):961-74 - PubMed
  14. Toxicology. 2010 Dec 5;278(2):211-6 - PubMed
  15. Cell Signal. 2012 May;24(5):981-90 - PubMed
  16. Front Physiol. 2016 Jun 22;7:249 - PubMed
  17. Free Radic Biol Med. 2008 Jan 15;44(2):126-31 - PubMed
  18. Free Radic Res. 2004 Dec;38(12):1269-79 - PubMed
  19. Curr Diab Rep. 2017 Jun;17(6):41 - PubMed
  20. Physiol Rev. 2008 Oct;88(4):1243-76 - PubMed
  21. PLoS Med. 2009 Jul 21;6(7):e1000097 - PubMed
  22. Mol Cell Biol. 2016 May 02;36(10):1426-37 - PubMed
  23. Front Genet. 2014 Jul 17;5:217 - PubMed
  24. Free Radic Res. 1997 Jun;26(6):507-14 - PubMed
  25. Mutagenesis. 1994 May;9(3):269-72 - PubMed
  26. Mutat Res. 1995 Apr;346(4):195-202 - PubMed
  27. Exp Physiol. 2010 Jan;95(1):1-9 - PubMed
  28. FASEB J. 2005 Jan;19(1):82-4 - PubMed
  29. Amino Acids. 2004 Mar;26(2):203-7 - PubMed
  30. Physiol Rev. 1979 Jul;59(3):527-605 - PubMed
  31. Eur J Appl Physiol. 2006 Sep;98(2):124-31 - PubMed
  32. Front Physiol. 2015 Jun 17;6:182 - PubMed
  33. Trends Plant Sci. 2017 Jan;22(1):11-19 - PubMed
  34. Toxicology. 2003 Jul 15;189(1-2):41-54 - PubMed
  35. Redox Rep. 2005;10(6):325-31 - PubMed
  36. Med Sci Sports Exerc. 2011 Sep;43(9):1770-6 - PubMed
  37. Int J Sports Med. 2017 Dec;38(14):1111-1116 - PubMed
  38. DNA Repair (Amst). 2013 Oct;12(10):856-63 - PubMed
  39. Biochem Biophys Res Commun. 2009 May 22;383(1):103-7 - PubMed
  40. Sports Med. 2017 Feb;47(2):277-293 - PubMed
  41. Curr Pharm Des. 2016;22(24):3648-80 - PubMed
  42. Free Radic Biol Med. 2003 Jun 15;34(12):1575-88 - PubMed
  43. Mol Cell Biochem. 2003 Nov;253(1-2):307-12 - PubMed
  44. Cell Signal. 2016 Apr;28(4):256-71 - PubMed
  45. Redox Biol. 2017 Aug;12:285-290 - PubMed
  46. J Sport Health Sci. 2016 Dec;5(4):448-455 - PubMed
  47. Free Radic Biol Med. 2008 Jan 15;44(2):123-5 - PubMed
  48. Environ Health Prev Med. 2007 Sep;12(5):202-8 - PubMed
  49. Free Radic Biol Med. 2004 Apr 15;36(8):966-75 - PubMed
  50. Environ Mol Mutagen. 2011 Jan;52(1):35-42 - PubMed
  51. Free Radic Biol Med. 1998 Jan 15;24(2):245-51 - PubMed
  52. Med Sci Sports Exerc. 2013 Aug;45(8):1469-77 - PubMed
  53. Exp Gerontol. 2019 Mar;117:113-118 - PubMed
  54. BMJ. 1997 Sep 13;315(7109):629-34 - PubMed
  55. Free Radic Biol Med. 2001 Dec 1;31(11):1465-72 - PubMed
  56. Eur J Appl Physiol. 2010 Sep;110(2):307-14 - PubMed
  57. Arch Intern Med. 2009 Feb 9;169(3):269-78 - PubMed
  58. Free Radic Biol Med. 2016 Sep;98:13-17 - PubMed
  59. Ageing Res Rev. 2008 Jan;7(1):34-42 - PubMed
  60. Biochem J. 2009 Jan 1;417(1):1-13 - PubMed
  61. Free Radic Res. 1998 Dec;29(6):581-4 - PubMed
  62. Free Radic Res. 2012 Apr;46(4):382-419 - PubMed
  63. Exp Mol Med. 2004 Dec 31;36(6):505-9 - PubMed
  64. Ann N Y Acad Sci. 2011 Jul;1229:115-23 - PubMed
  65. Dyn Med. 2009 Jan 13;8:1 - PubMed
  66. Ann Clin Lab Sci. 2012 Summer;42(3):320-37 - PubMed
  67. Jpn J Cancer Res. 1993 Jul;84(7):720-5 - PubMed
  68. Cancer Lett. 2012 Dec 31;327(1-2):123-33 - PubMed
  69. JAMA. 2004 Mar 10;291(10):1238-45 - PubMed
  70. Adv Clin Chem. 2017;81:193-230 - PubMed
  71. Compr Physiol. 2012 Apr;2(2):1143-211 - PubMed
  72. Physiol Behav. 2005 Jan 31;84(1):1-7 - PubMed
  73. Mutat Res. 2009 Jul-Aug;682(1):28-38 - PubMed
  74. Biochem Biophys Res Commun. 2003 May 30;305(2):333-8 - PubMed
  75. Mitochondrion. 2012 Jan;12(1):1-4 - PubMed
  76. Am J Clin Nutr. 2008 Jan;87(1):142-9 - PubMed
  77. J Phys Ther Sci. 2016 Jan;28(2):450-5 - PubMed
  78. Free Radic Res. 2009 Aug;43(8):753-60 - PubMed
  79. FASEB J. 2001 May;15(7):1181-6 - PubMed
  80. Biochem Soc Trans. 2002 Apr;30(2):280-5 - PubMed
  81. Free Radic Res. 2013 Mar;47(3):202-11 - PubMed
  82. Antioxidants (Basel). 2018 May 21;7(5):null - PubMed
  83. Int J Sport Nutr Exerc Metab. 2005 Oct;15(5):480-92 - PubMed
  84. Sports Med. 2006;36(4):327-58 - PubMed
  85. J Sports Med Phys Fitness. 1998 Jun;38(2):111-5 - PubMed
  86. Biochem J. 1972 Jul;128(3):617-30 - PubMed
  87. Med Sci Sports Exerc. 2006 Jun;38(6):1098-105 - PubMed
  88. Med Sci Sports Exerc. 2008 Aug;40(8):1455-62 - PubMed
  89. Ageing Res Rev. 2008 Jan;7(1):1-7 - PubMed
  90. P T. 2008 Dec;33(12):700-11 - PubMed
  91. Biochem Soc Trans. 2011 Oct;39(5):1299-304 - PubMed
  92. Life Sci. 2000 Mar 24;66(18):1763-7 - PubMed
  93. Br J Nutr. 2013 Jan 28;109(2):293-301 - PubMed
  94. Sci Rep. 2016 Mar 04;6:22682 - PubMed

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