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Imprialos K, Stavropoulos K, Papademetriou V. Sodium-Glucose Cotransporter-2 Inhibitors, Reverse J-Curve Pattern, and Mortality in Heart Failure. Heart Fail Clin. 2019;15(4):519-530doi: 10.1016/j.hfc.2019.06.004.
Imprialos, K., Stavropoulos, K., & Papademetriou, V. (2019). Sodium-Glucose Cotransporter-2 Inhibitors, Reverse J-Curve Pattern, and Mortality in Heart Failure. Heart failure clinics, 15(4), 519-530. https://doi.org/10.1016/j.hfc.2019.06.004
Imprialos, Konstantinos, et al. "Sodium-Glucose Cotransporter-2 Inhibitors, Reverse J-Curve Pattern, and Mortality in Heart Failure." Heart failure clinics vol. 15,4 (2019): 519-530. doi: https://doi.org/10.1016/j.hfc.2019.06.004
Imprialos K, Stavropoulos K, Papademetriou V. Sodium-Glucose Cotransporter-2 Inhibitors, Reverse J-Curve Pattern, and Mortality in Heart Failure. Heart Fail Clin. 2019 Oct;15(4):519-530. doi: 10.1016/j.hfc.2019.06.004. Epub 2019 Aug 07. PMID: 31472887.
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Heart Fail Clin. 2019 Oct;15(4):519-530. doi: 10.1016/j.hfc.2019.06.004. Epub 2019 Aug 07.

Sodium-Glucose Cotransporter-2 Inhibitors, Reverse J-Curve Pattern, and Mortality in Heart Failure.

Heart failure clinics

Konstantinos Imprialos, Konstantinos Stavropoulos, Vasilios Papademetriou

Affiliations

  1. VAMC and Georgetown University, 50 Irving Street, Washington, DC 20422, USA.
  2. VAMC and Georgetown University, 50 Irving Street, Washington, DC 20422, USA. Electronic address: [email protected].

PMID: 31472887 DOI: 10.1016/j.hfc.2019.06.004

Abstract

The prevalence of diabetes mellitus and heart failure is increasing. The novel sodium-glucose cotransporters 2 inhibitors offer multidimensional ameliorating effects on cardiovascular and heart failure risk factors. Several studies have assessed the impact on cardiovascular events, with data suggesting beneficial effects on cardiovascular events in high-risk patients with diabetes in patients with heart failure. The reverse J-curve pattern between blood pressure levels and mortality has emerged as an important topic in the field of heart failure. There is no significant evidence to propose any potential effect of sodium-glucose co-transporter 2 inhibitors on the J-shape-suggested mortality in patients with heart failure.

Copyright © 2019 Elsevier Inc. All rights reserved.

Keywords: Cardiovascular events; Heart failure; Mortality; Reverse J-curve; SGLT-2 inhibitors

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