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J Clin Med. 2019 Sep 08;8(9). doi: 10.3390/jcm8091416.

Physician Adherence to Treat-to-Target and Practice Guidelines in Rheumatoid Arthritis.

Journal of clinical medicine

Bogdan Batko, Krzysztof Batko, Marcin Krzanowski, Zbigniew Żuber

Affiliations

  1. Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski University, Gustawa Herlinga-Grud?i?skiego 1 St, 30-705 Cracow, Poland. [email protected].
  2. Department of Rheumatology, J. Dietl Specialist Hospital, Skarbowa 1 St, 31-121 Cracow, Poland. [email protected].
  3. Chair and Head of Nephrology, Jagiellonian University Medical College, Kopernika St 15c, 31-501 Cracow, Poland. [email protected].
  4. Chair and Head of Nephrology, Jagiellonian University Medical College, Kopernika St 15c, 31-501 Cracow, Poland. [email protected].
  5. Department of Pediatrics, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski University, Gustawa Herlinga-Grud?i?skiego 1 St, 30-705 Cracow, Poland. [email protected].
  6. Ward for Older Children with Neurology and Rheumatology Subdivision, St. Louis Regional Specialised Children's Hospital, 31-503 Cracow, Poland. [email protected].

PMID: 31500394 PMCID: PMC6780913 DOI: 10.3390/jcm8091416

Abstract

Principles of treat-to-target (T2T) have been widely adopted in both multinational and regional guidelines for rheumatoid arthritis (RA). Several questionnaire studies among physicians and real-world data have suggested that an evidence-practice gap exists in RA management. Investigating physician adherence to T2T, which requires a process measure, is difficult. Different practice patterns among physicians are observed, while adherence to protocolized treatment declines over time. Rheumatologist awareness, agreement, and claims of adherence to T2T guidelines are not always consistent with medical records. Comorbidities, a difficult disease course, communication barriers, and individual preferences may hinder an intensive, proactive treatment stance. Interpreting deviations from protocolized treatment/T2T guidelines requires sufficient clinical context, though higher adherence seems to improve clinical outcomes. Nonmedical constraints in routine care may consist of barriers in healthcare structure and socioeconomic factors. Therefore, strategies to improve the institution of T2T should be tailored to local healthcare. Educational interventions to improve T2T adherence among physicians may show a moderate, although beneficial effect. Meanwhile, a proportion of patients with inadequately controlled RA exists, while management decisions may not be in accordance with T2T. Physicians tend to be aware of current guidelines, but their institution in routine practice seems challenging, which warrants attention and further study.

Keywords: arthritis; guideline adherence; physicians; physicians’; practice patterns; rheumatoid; rheumatologists; treat-to-target

Conflict of interest statement

The authors declare no conflict of interest.

References

  1. Ann Rheum Dis. 2016 Jan;75(1):3-15 - PubMed
  2. Ann Intern Med. 2001 Nov 6;135(9):825-34 - PubMed
  3. Clin Rheumatol. 2019 Sep;38(9):2473-2481 - PubMed
  4. Rheumatology (Oxford). 2017 Jan;56(1):68-76 - PubMed
  5. J Rheumatol. 2018 Oct;45(10):1367-1374 - PubMed
  6. Arthritis Rheumatol. 2018 Oct;70(10):1544-1554 - PubMed
  7. Arthritis Res Ther. 2012 Nov 23;14(6):R254 - PubMed
  8. Rheumatology (Oxford). 2010 Apr;49(4):741-8 - PubMed
  9. Arthritis Care Res (Hoboken). 2016 Apr;68(4):446-53 - PubMed
  10. Ann Rheum Dis. 2014 Jan;73(1):62-8 - PubMed
  11. Ann Rheum Dis. 2016 Jan;75(1):16-22 - PubMed
  12. Mod Rheumatol. 2015 Jan;25(1):43-9 - PubMed
  13. Rheumatol Int. 2019 Jun;39(6):1077-1082 - PubMed
  14. Clin Rheumatol. 2017 Feb;36(2):317-326 - PubMed
  15. RMD Open. 2016 Aug 18;2(2):e000202 - PubMed
  16. Clin Exp Rheumatol. 2018 Sep-Oct;36(5):820-828 - PubMed
  17. Arthritis Care Res (Hoboken). 2018 May;70(5):801-806 - PubMed
  18. Rheumatology (Oxford). 2010 Nov;49(11):2154-64 - PubMed
  19. Clin Ther. 2016 May;38(5):1122-33 - PubMed
  20. Arthritis Res Ther. 2016 Apr 26;18:94 - PubMed
  21. Clin Exp Rheumatol. 2014 Sep-Oct;32(5 Suppl 85):S-141-6 - PubMed
  22. Ann Rheum Dis. 2012 Nov;71(11):1803-8 - PubMed
  23. Rheumatol Int. 2018 Dec;38(12):2167-2182 - PubMed
  24. Rheumatology (Oxford). 2018 Nov 1;57(11):1933-1937 - PubMed
  25. RMD Open. 2015 Mar 04;1(1):e000041 - PubMed
  26. BMC Musculoskelet Disord. 2018 Oct 30;19(1):389 - PubMed
  27. RMD Open. 2018 Mar 17;4(1):e000615 - PubMed
  28. Arthritis Rheumatol. 2017 Jul;69(7):1374-1380 - PubMed
  29. RMD Open. 2016 Apr 28;2(1):e000221 - PubMed
  30. Clin Exp Rheumatol. 2018 Jan-Feb;36(1):21-28 - PubMed
  31. Int J Rheumatol. 2017;2017:1201450 - PubMed
  32. Arthritis Care Res (Hoboken). 2018 Mar;70(3):379-387 - PubMed
  33. BMC Rheumatol. 2018 Jun 26;2:16 - PubMed
  34. Arthritis Care Res (Hoboken). 2014 Feb;66(2):190-6 - PubMed
  35. Clin Med (Lond). 2013 Feb;13(1):42-6 - PubMed
  36. RMD Open. 2016 May 17;2(1):e000195 - PubMed
  37. Rheumatol Int. 2016 May;36(5):685-95 - PubMed
  38. Arthritis Res Ther. 2017 Sep 26;19(1):212 - PubMed
  39. Semin Arthritis Rheum. 2019 Apr;48(5):808-814 - PubMed
  40. Arch Med Sci. 2019 Jan;15(1):134-140 - PubMed
  41. Ann Rheum Dis. 2014 Jan;73(1):198-206 - PubMed
  42. Health Qual Life Outcomes. 2018 Nov 9;16(1):211 - PubMed
  43. Am Health Drug Benefits. 2018 May;11(3):148-158 - PubMed
  44. Rheumatol Int. 2018 Aug;38(8):1437-1442 - PubMed
  45. J Rheumatol. 2012 Dec;39(12):2247-52 - PubMed
  46. Med Care. 1991 Aug;29(8):799-812 - PubMed
  47. Rheumatol Int. 2018 Jun;38(6):935-947 - PubMed
  48. Clin Exp Rheumatol. 2017 May-Jun;35(3):477-483 - PubMed
  49. J Clin Rheumatol. 2016 Mar;22(2):63-7 - PubMed
  50. Arthritis Rheum. 2012 Mar;64(3):630-8 - PubMed
  51. J Clin Med. 2019 Jun 28;8(7):null - PubMed
  52. Int J Rheum Dis. 2013 Oct;16(5):532-8 - PubMed
  53. J Clin Med. 2019 Mar 03;8(3):null - PubMed
  54. Scand J Rheumatol. 2015;44(6):449-55 - PubMed
  55. Arthritis Care Res (Hoboken). 2016 Dec;68(12):1767-1773 - PubMed
  56. Ann Rheum Dis. 2011 Nov;70(11):1999-2002 - PubMed
  57. Clin Rheumatol. 2018 May;37(5):1189-1197 - PubMed
  58. Rheumatol Ther. 2018 Dec;5(2):355-369 - PubMed
  59. J Rheumatol. 2018 Jan;45(1):40-44 - PubMed
  60. Int J Rheum Dis. 2017 May;20(5):576-583 - PubMed
  61. BMC Fam Pract. 2013 Oct 10;14:150 - PubMed
  62. J Clin Med. 2018 Oct 09;7(10):null - PubMed
  63. Arthritis Res Ther. 2015 Mar 08;17:48 - PubMed
  64. Clin Rheumatol. 2019 Mar;38(3):727-738 - PubMed
  65. J Clin Med. 2019 Apr 15;8(4):null - PubMed
  66. Patient Prefer Adherence. 2018 Oct 04;12:2007-2014 - PubMed
  67. Ann Rheum Dis. 2010 Apr;69(4):638-643 - PubMed

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