Display options
Cite
Urbaniak T, Musiał W. Influence of Solvent Evaporation Technique Parameters on Diameter of Submicron Lamivudine-Poly-ε-Caprolactone Conjugate Particles. Nanomaterials (Basel). 2019;9(9)doi: 10.3390/nano9091240.
Urbaniak, T., & Musiał, W. (2019). Influence of Solvent Evaporation Technique Parameters on Diameter of Submicron Lamivudine-Poly-ε-Caprolactone Conjugate Particles. Nanomaterials (Basel, Switzerland), 9(9), . https://doi.org/10.3390/nano9091240
Urbaniak, Tomasz, and Musiał, Witold. "Influence of Solvent Evaporation Technique Parameters on Diameter of Submicron Lamivudine-Poly-ε-Caprolactone Conjugate Particles." Nanomaterials (Basel, Switzerland) vol. 9,9 (2019). doi: https://doi.org/10.3390/nano9091240
Urbaniak T, Musiał W. Influence of Solvent Evaporation Technique Parameters on Diameter of Submicron Lamivudine-Poly-ε-Caprolactone Conjugate Particles. Nanomaterials (Basel). 2019 Aug 31;9(9). doi: 10.3390/nano9091240. PMID: 31480469; PMCID: PMC6780331.
Copy Download .nbib Format: NLM
Share it on

Nanomaterials (Basel). 2019 Aug 31;9(9). doi: 10.3390/nano9091240.

Influence of Solvent Evaporation Technique Parameters on Diameter of Submicron Lamivudine-Poly-ε-Caprolactone Conjugate Particles.

Nanomaterials (Basel, Switzerland)

Tomasz Urbaniak, Witold Musiał

Affiliations

  1. Department of Physical Chemistry and Biophysics, Pharmaceutical Faculty, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
  2. Department of Physical Chemistry and Biophysics, Pharmaceutical Faculty, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland. [email protected].

PMID: 31480469 PMCID: PMC6780331 DOI: 10.3390/nano9091240

Abstract

The size of active pharmaceutical ingredient carrier is one of the key properties considered during design of submicron drug delivery systems. Particle diameter may determine drug biodistribution, cellular uptake, and elimination path. Solvent evaporation technique is a flexible method of particle preparation, in which various macromolecules and drugs may be employed. Parameters of emulsion obtained as first step of particle preparation are crucial in terms of particle size, drug loading, and morphology. The aim of the study was to investigate the influence of emulsion preparation parameters on diameter of resulting particles. Impact of surfactant type and concentration, homogenization time, homogenization rate, phase ratio, and conjugate concentration were evaluated. Model drug lamivudine was covalently bound to polymer and applied in solvent evaporation method in order to overcome issues related to drug loading and provide method-independent incorporation. Synthesized drug-polymer conjugate and obtained particles were evaluated via dynamic light scattering, chromatography, scanning electron microscopy, and spectroscopic methods. Covalent bonding between drug and polymeric chain was confirmed, estimated drug content per milligram of conjugate was 19 μg. Among employed colloid stabilizer, poly(vinyl alcohol) was proven to be most effective. Homogenization rate and surfactant concentration were identified as crucial parameters in terms of particle diameter control.

Keywords: biodegradable polymers; drug delivery; drug-polymer conjugates; solvent evaporation technique; submicron particle preparation

References

  1. Int J Nanomedicine. 2012;7:5577-91 - PubMed
  2. Cancer Biol Med. 2017 Aug;14(3):228-241 - PubMed
  3. Dev Cell. 2016 Jul 25;38(2):135-46 - PubMed
  4. Front Immunol. 2015 Nov 25;6:602 - PubMed
  5. Acta Biomater. 2018 Jun;73:412-423 - PubMed
  6. Biomed Res Int. 2017;2017:9042851 - PubMed
  7. J Nanobiotechnology. 2014 May 12;12:20 - PubMed
  8. J Microencapsul. 2010 May;27(3):187-97 - PubMed
  9. Expert Opin Drug Deliv. 2015 Jun;12(6):1009-26 - PubMed
  10. Eur J Pharm Sci. 2010 Nov 20;41(3-4):498-507 - PubMed
  11. Nanomedicine (Lond). 2016 Mar;11(6):673-92 - PubMed
  12. Biomagn Res Technol. 2007 Apr 04;5:2 - PubMed
  13. Molecules. 2019 Feb 17;24(4):null - PubMed
  14. Biomacromolecules. 2017 Dec 11;18(12):3963-3970 - PubMed
  15. Acta Pharm. 2014 Dec;64(4):403-17 - PubMed
  16. Int J Pharm. 2015 Dec 30;496(2):173-90 - PubMed
  17. Bioorg Med Chem. 2017 Mar 1;25(5):1696-1702 - PubMed
  18. J Control Release. 2010 Feb 15;141(3):320-7 - PubMed
  19. Res Pharm Sci. 2014 Nov-Dec;9(6):407-20 - PubMed
  20. J Nanobiotechnology. 2014 Feb 03;12:5 - PubMed
  21. Bioconjug Chem. 2007 Nov-Dec;18(6):2097-108 - PubMed
  22. Nanomedicine (Lond). 2009 Dec;4(8):903-17 - PubMed
  23. Trends Pharmacol Sci. 2018 Jun;39(6):536-546 - PubMed
  24. J Microencapsul. 2006 Aug;23(5):471-9 - PubMed
  25. Small. 2011 Jul 18;7(14):1919-31 - PubMed
  26. PDA J Pharm Sci Technol. 2013 May-Jun;67(3):186-200 - PubMed
  27. J Pharm Pharmacol. 1977 Mar;29(3):157-62 - PubMed
  28. J Colloid Interface Sci. 2007 Aug 15;312(2):363-80 - PubMed
  29. Data Brief. 2015 Nov 25;6:15-9 - PubMed

Publication Types

Grant support