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Poradowski D, Obmińska-Mrukowicz B. Effect of Selected Nonsteroidal Anti-inflammatory Drugs on the Viability of Canine Osteosarcoma Cells of the D-17 Line: . J Vet Res. 2019;63(3):399-403doi: 10.2478/jvetres-2019-0051.
Poradowski, D., & Obmińska-Mrukowicz, B. (2019). Effect of Selected Nonsteroidal Anti-inflammatory Drugs on the Viability of Canine Osteosarcoma Cells of the D-17 Line: . Journal of veterinary research, 63(3), 399-403. https://doi.org/10.2478/jvetres-2019-0051
Poradowski, Dominik, and Obmińska-Mrukowicz, Bożena. "Effect of Selected Nonsteroidal Anti-inflammatory Drugs on the Viability of Canine Osteosarcoma Cells of the D-17 Line: ." Journal of veterinary research vol. 63,3 (2019): 399-403. doi: https://doi.org/10.2478/jvetres-2019-0051
Poradowski D, Obmińska-Mrukowicz B. Effect of Selected Nonsteroidal Anti-inflammatory Drugs on the Viability of Canine Osteosarcoma Cells of the D-17 Line: . J Vet Res. 2019 Sep 13;63(3):399-403. doi: 10.2478/jvetres-2019-0051. eCollection 2019 Sep. PMID: 31572821; PMCID: PMC6749731.
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J Vet Res. 2019 Sep 13;63(3):399-403. doi: 10.2478/jvetres-2019-0051. eCollection 2019 Sep.

Effect of Selected Nonsteroidal Anti-inflammatory Drugs on the Viability of Canine Osteosarcoma Cells of the D-17 Line: .

Journal of veterinary research

Dominik Poradowski, Bożena Obmińska-Mrukowicz

Affiliations

  1. Division of Animal Anatomy, Department of Biostructure and Animal Physiology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 51-631 Wroc?aw, Poland.
  2. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-375 Wroc?aw, Poland.

PMID: 31572821 PMCID: PMC6749731 DOI: 10.2478/jvetres-2019-0051

Abstract

INTRODUCTION: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in veterinary medicine. They are used in pain control and in anti-inflammatory and antipyretic therapies. Some NSAIDs,

MATERIAL AND METHODS: The viability of the cells was evaluated using the MTT assay. Four independent repetitions were performed and the results are given as the average of these values; EC

RESULTS: The analysis of results showed that carprofen and tolfenamic acid displayed the highest cytotoxicity. Other drugs either did not provide such effects or they were very poor. For carprofen, it was possible to determine an EC

CONCLUSION: The results are promising but further studies should be conducted to confirm them, since this study is only preliminary. The possibility of introducing carprofen and tolfenamic acid into the routine treatment of osteosarcoma in dogs should be considered.

© 2019 D. Poradowski, B. Obmińska-Mrukowicz. published by Sciendo.

Keywords: canine osteosarcoma; cytotoxicity assay; dogs; non-steroidal anti-inflammatory drugs

Conflict of interest statement

Conflict of Interest Conflict of Interests Statement: The authors declare that there is no conflict of interests regarding the publication of this article.

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