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Krishnamachary B, Subramaniam D, Dandawate P, et al. Targeting transcription factor TCF4 by γ-Mangostin, a natural xanthone. Oncotarget. 2019;10(54):5576-5591doi: 10.18632/oncotarget.27159.
Krishnamachary, B., Subramaniam, D., Dandawate, P., Ponnurangam, S., Srinivasan, P., Ramamoorthy, P., Umar, S., Thomas, S. M., Dhar, A., Septer, S., Weir, S. J., Attard, T., & Anant, S. (2019). Targeting transcription factor TCF4 by γ-Mangostin, a natural xanthone. Oncotarget, 10(54), 5576-5591. https://doi.org/10.18632/oncotarget.27159
Krishnamachary, Balaji, et al. "Targeting transcription factor TCF4 by γ-Mangostin, a natural xanthone." Oncotarget vol. 10,54 (2019): 5576-5591. doi: https://doi.org/10.18632/oncotarget.27159
Krishnamachary B, Subramaniam D, Dandawate P, Ponnurangam S, Srinivasan P, Ramamoorthy P, Umar S, Thomas SM, Dhar A, Septer S, Weir SJ, Attard T, Anant S. Targeting transcription factor TCF4 by γ-Mangostin, a natural xanthone. Oncotarget. 2019 Sep 24;10(54):5576-5591. doi: 10.18632/oncotarget.27159. eCollection 2019 Sep 24. PMID: 31608135; PMCID: PMC6771460.
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Oncotarget. 2019 Sep 24;10(54):5576-5591. doi: 10.18632/oncotarget.27159. eCollection 2019 Sep 24.

Targeting transcription factor TCF4 by γ-Mangostin, a natural xanthone.

Oncotarget

Balaji Krishnamachary, Dharmalingam Subramaniam, Prasad Dandawate, Sivapriya Ponnurangam, Pugazhendhi Srinivasan, Prabhu Ramamoorthy, Shahid Umar, Sufi Mary Thomas, Animesh Dhar, Seth Septer, Scott J Weir, Thomas Attard, Shrikant Anant

Affiliations

  1. Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS, USA.
  2. Department of General Surgery, University of Kansas Medical Center, Kansas City, KS, USA.
  3. Department of Otolaryngology, University of Kansas Medical Center, Kansas City, KS, USA.
  4. Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, University of Colorado, Aurora, CO, USA.
  5. Department of Pediatrics, Division of Gastroenterology, Children's Mercy Hospital, Kansas City, KS, USA.

PMID: 31608135 PMCID: PMC6771460 DOI: 10.18632/oncotarget.27159

Abstract

Given that colon cancer is the third most common cancer in incidence and cause of death in the United States, and current treatment modalities are insufficient, there is a need to develop novel agents. Towards this, here we focus on γ-Mangostin, a bioactive compound present in the Mangosteen (

Copyright: © 2019 Krishnamachary et al.

Keywords: Wnt signaling; beta-catenin; natural product; preventive agent; tumor xenograft

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

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