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Grimaldi A, Pediconi N, Oieni F, et al. Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer's Disease Patients, Possible Biomarkers for Early Diagnosis. Front Neurosci. 2019;13:925doi: 10.3389/fnins.2019.00925.
Grimaldi, A., Pediconi, N., Oieni, F., Pizzarelli, R., Rosito, M., Giubettini, M., Santini, T., Limatola, C., Ruocco, G., Ragozzino, D., & Di Angelantonio, S. (2019). Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer's Disease Patients, Possible Biomarkers for Early Diagnosis. Frontiers in neuroscience, 13925. https://doi.org/10.3389/fnins.2019.00925
Grimaldi, Alfonso, et al. "Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer's Disease Patients, Possible Biomarkers for Early Diagnosis." Frontiers in neuroscience vol. 13 (2019): 925. doi: https://doi.org/10.3389/fnins.2019.00925
Grimaldi A, Pediconi N, Oieni F, Pizzarelli R, Rosito M, Giubettini M, Santini T, Limatola C, Ruocco G, Ragozzino D, Di Angelantonio S. Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer's Disease Patients, Possible Biomarkers for Early Diagnosis. Front Neurosci. 2019 Sep 04;13:925. doi: 10.3389/fnins.2019.00925. eCollection 2019. PMID: 31551688; PMCID: PMC6737046.
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Front Neurosci. 2019 Sep 04;13:925. doi: 10.3389/fnins.2019.00925. eCollection 2019.

Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer's Disease Patients, Possible Biomarkers for Early Diagnosis.

Frontiers in neuroscience

Alfonso Grimaldi, Natalia Pediconi, Francesca Oieni, Rocco Pizzarelli, Maria Rosito, Maria Giubettini, Tiziana Santini, Cristina Limatola, Giancarlo Ruocco, Davide Ragozzino, Silvia Di Angelantonio

Affiliations

  1. Center for Life Nanoscience, Istituto Italiano di Tecnologia, Rome, Italy.
  2. Department of Physiology and Pharmacology, Sapienza University, Rome, Italy.
  3. Crestoptics S.p.A., Rome, Italy.
  4. IRCCS Neuromed, Pozzilli, Italy.
  5. Department of Physics, Sapienza University, Rome, Italy.

PMID: 31551688 PMCID: PMC6737046 DOI: 10.3389/fnins.2019.00925

Abstract

Alzheimer's disease (AD), a primary cause of dementia in the aging population, is characterized by extracellular amyloid-beta peptides aggregation, intracellular deposits of hyperphosphorylated tau, neurodegeneration and glial activation in the brain. It is commonly thought that the lack of early diagnostic

Keywords: Alzheimer’s disease; astrocytes; beta-amyloid; human; microglia; neurodegeneration; retina; tau

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