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Genova C, Boccardo S, Mora M, et al. Correlation between B7-H4 and Survival of Non-Small-Cell Lung Cancer Patients Treated with Nivolumab. J Clin Med. 2019;8(10)doi: 10.3390/jcm8101566.
Genova, C., Boccardo, S., Mora, M., Rijavec, E., Biello, F., Rossi, G., Tagliamento, M., Dal Bello, M. G., Coco, S., Alama, A., Vanni, I., Barletta, G., Bianchi, R., Maggioni, C., Bruzzi, P., & Grossi, F. (2019). Correlation between B7-H4 and Survival of Non-Small-Cell Lung Cancer Patients Treated with Nivolumab. Journal of clinical medicine, 8(10), . https://doi.org/10.3390/jcm8101566
Genova, Carlo, et al. "Correlation between B7-H4 and Survival of Non-Small-Cell Lung Cancer Patients Treated with Nivolumab." Journal of clinical medicine vol. 8,10 (2019). doi: https://doi.org/10.3390/jcm8101566
Genova C, Boccardo S, Mora M, Rijavec E, Biello F, Rossi G, Tagliamento M, Dal Bello MG, Coco S, Alama A, Vanni I, Barletta G, Bianchi R, Maggioni C, Bruzzi P, Grossi F. Correlation between B7-H4 and Survival of Non-Small-Cell Lung Cancer Patients Treated with Nivolumab. J Clin Med. 2019 Oct 01;8(10). doi: 10.3390/jcm8101566. PMID: 31581482; PMCID: PMC6832616.
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J Clin Med. 2019 Oct 01;8(10). doi: 10.3390/jcm8101566.

Correlation between B7-H4 and Survival of Non-Small-Cell Lung Cancer Patients Treated with Nivolumab.

Journal of clinical medicine

Carlo Genova, Simona Boccardo, Marco Mora, Erika Rijavec, Federica Biello, Giovanni Rossi, Marco Tagliamento, Maria Giovanna Dal Bello, Simona Coco, Angela Alama, Irene Vanni, Giulia Barletta, Rita Bianchi, Claudia Maggioni, Paolo Bruzzi, Francesco Grossi

Affiliations

  1. Lung Cancer Unit, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy. [email protected].
  2. Lung Cancer Unit, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy. [email protected].
  3. Pathology Unit, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy. [email protected].
  4. Medical Oncology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza, 28, 20122 Milan, Italy. [email protected].
  5. Oncology Unit, Ospedale Maggiore della Carità, Corso Mazzini 18, 28100 Novara, Italy. [email protected].
  6. Lung Cancer Unit, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy. [email protected].
  7. Lung Cancer Unit, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy. [email protected].
  8. Lung Cancer Unit, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy. [email protected].
  9. Lung Cancer Unit, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy. [email protected].
  10. Lung Cancer Unit, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy. [email protected].
  11. Lung Cancer Unit, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy. [email protected].
  12. Lung Cancer Unit, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy. [email protected].
  13. Pathology Unit, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy. [email protected].
  14. Lung Cancer Unit, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy. [email protected].
  15. Department of Epidemiology, Biostatistics and Clinical Trials, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy. [email protected].
  16. Medical Oncology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza, 28, 20122 Milan, Italy. [email protected].

PMID: 31581482 PMCID: PMC6832616 DOI: 10.3390/jcm8101566

Abstract

Reliable predictors of benefit from immune checkpoint inhibitors in non-small-cell lung cancer (NSCLC) are still limited. We aimed to evaluate the association between the expression of selected molecules involved in immune response and clinical outcomes in NSCLC patients receiving nivolumab. In our study, the outcomes of 46 NSCLC patients treated with nivolumab in second or subsequent lines (Nivolumab Cohort) were compared with the expression of PD-L1, PD-L2, PD-1, B7-H3, and B7-H4 assessed by immunohistochemistry (IHC). Samples from 17 patients (37.0%) in the Nivolumab Cohort were positive for B7-H4 expression. At univariate analyses, only B7-H4 expression was associated with significantly decreased progression-free survival (PFS; 1.7 vs. 2.0 months;

Keywords: B7-H4; immune checkpoint inhibitors; immunohistochemistry; nivolumab; non-small-cell lung cancer

References

  1. Oncotarget. 2017 Jan 10;8(2):2171-2186 - PubMed
  2. J Thorac Oncol. 2016 Nov;11(11):1863-1868 - PubMed
  3. Front Oncol. 2017 Apr 06;7:67 - PubMed
  4. J Immunother Cancer. 2016 Aug 16;4:48 - PubMed
  5. Eur J Immunol. 2009 Jul;39(7):1754-64 - PubMed
  6. J Thorac Oncol. 2017 Feb;12(2):208-222 - PubMed
  7. Lancet. 2016 Apr 9;387(10027):1540-1550 - PubMed
  8. Appl Immunohistochem Mol Morphol. 2015 Sep;23(8):541-9 - PubMed
  9. Hum Immunol. 2014 Dec;75(12):1203-9 - PubMed
  10. Nat Immunol. 2001 Mar;2(3):269-74 - PubMed
  11. Clin Dev Immunol. 2011;2011:695834 - PubMed
  12. Cancer Res. 2007 Sep 15;67(18):8900-5 - PubMed
  13. J Immunol. 2003 Nov 1;171(9):4650-4 - PubMed
  14. Oncotarget. 2016 Dec 6;7(49):81750-81756 - PubMed
  15. J Exp Med. 2014 May 5;211(5):943-59 - PubMed
  16. Acta Histochem. 2014 Sep;116(7):1163-8 - PubMed
  17. Cell Physiol Biochem. 2016;39(4):1568-80 - PubMed
  18. Oncotarget. 2016 Nov 22;7(47):76523-76533 - PubMed
  19. Oncol Lett. 2016 Mar;11(3):1841-1846 - PubMed
  20. Clin Cancer Res. 2017 Sep 1;23(17):5202-5209 - PubMed
  21. Br J Cancer. 2017 Jan 3;116(1):36-43 - PubMed
  22. Arch Pathol Lab Med. 2016 Apr;140(4):326-31 - PubMed
  23. Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5271-9 - PubMed
  24. N Engl J Med. 2015 Oct 22;373(17):1627-39 - PubMed
  25. Ann Oncol. 2016 Jan;27(1):147-53 - PubMed
  26. Oncotarget. 2017 Apr 18;8(16):27137-27144 - PubMed
  27. Monoclon Antib Immunodiagn Immunother. 2013 Dec;32(6):395-8 - PubMed
  28. Lung Cancer. 2017 Jan;103:44-51 - PubMed
  29. N Engl J Med. 2015 Jul 9;373(2):123-35 - PubMed
  30. Nat Immunol. 2001 Mar;2(3):261-8 - PubMed
  31. Drug Discov Today. 2017 Aug;22(8):1266-1273 - PubMed
  32. Oncotarget. 2017 Oct 4;8(52):90123-90131 - PubMed
  33. Gynecol Oncol. 2014 Jul;134(1):181-189 - PubMed
  34. J Immunol. 2004 Aug 15;173(4):2500-6 - PubMed
  35. Oncotarget. 2016 Nov 1;7(44):72242-72249 - PubMed

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