Display options
Share it on

J Child Psychol Psychiatry. 2020 Feb;61(2):116-130. doi: 10.1111/jcpp.13135. Epub 2019 Oct 14.

Practitioner Review: Twenty years of research with adverse childhood experience scores - Advantages, disadvantages and applications to practice.

Journal of child psychology and psychiatry, and allied disciplines

Rebecca E Lacey, Helen Minnis

Affiliations

  1. Research Department of Epidemiology and Public Health, University College London, London, UK.
  2. Institute of Health and Wellbeing, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

PMID: 31609471 DOI: 10.1111/jcpp.13135

Abstract

BACKGROUND: Adverse childhood experience (ACE) scores have become a common approach for considering childhood adversities and are highly influential in public policy and clinical practice. Their use is also controversial. Other ways of measuring adversity - examining single adversities, or using theoretically or empirically driven methods - might have advantages over ACE scores.

METHODS: In this narrative review we critique the conceptualisation and measurement of ACEs in research, clinical practice, public health and public discourse.

RESULTS: The ACE score approach has the advantages - and limitations - of simplicity: its simplicity facilitates wide-ranging applications in public policy, public health and clinical settings but risks over-simplistic communication of risk/causality, determinism and stigma. The other common approach - focussing on single adversities - is also limited because adversities tend to co-occur. Researchers are using rapidly accruing datasets on ACEs to facilitate new theoretical and empirical approaches but this work is at an early stage, e.g. weighting ACEs and including severity, frequency, duration and timing. More research is needed to establish what should be included as an ACE, how individual ACEs should be weighted, how ACEs cluster, and the implications of these findings for clinical work and policy. New ways of conceptualising and measuring ACEs that incorporate this new knowledge, while maintaining some of the simplicity of the current ACE questionnaire, could be helpful for clinicians, practitioners, patients and the public.

CONCLUSIONS: Although we welcome the current focus on ACEs, a more critical view of their conceptualisation, measurement, and application to practice settings is urgently needed.

© 2019 Association for Child and Adolescent Mental Health.

Keywords: Adversity; child abuse; early life experience; social psychiatry; social work

References

  1. ACE Aware Scotland (2018). Conference - ACE Aware Scotland. Available from: http://aceawarescotland.com/conference/ [last accessed 15 October 2018]. - PubMed
  2. ACE Aware Wales (2019). ACE Aware Wales. Available from: https://www.aceawarewales.com/about [last accessed 8 March 2019]. - PubMed
  3. Alastalo, H., Räikkönen, K., Pesonen, A.K., Osmond, C., Barker, D.J.P., Heinonen, K., … & Eriksson, J.G. (2013). Early life stress and blood pressure levels in late adulthood. Journal of Human Hypertension, 27, 90-94. - PubMed
  4. Alcalá, H.E., Mitchell, E.M., & Keim-Malpass, J. (2018). Heterogeneous impacts: Adverse childhood experiences and cancer screening. Cancer Causes and Control, 29, 343-351. - PubMed
  5. Allnock, D., & Miller, P. (2013). No one noticed, no one heard: A study of disclosures of childhood abuse. Available from: https://learning.nspcc.org.uk/media/1052/no-one-noticed-no-one-heard-report.pdf [last accessed 15 October 2018]. - PubMed
  6. Anda, R., Croft, J., Felitti, V., Nordenberg, D., Giles, W., Williamson, D., & Giovino, G. (1999). Adverse childhood experiences and smoking during adolescence and adulthood. JAMA, 282, 1652-1658. - PubMed
  7. Andermann, A., Blancquaert, I., Beauchamp, S., & Déry, V. (2008). Revisiting Wilson and Jungner in the genomic age: a review of screening criteria over the past 40 years. Bulletin of the World Health Organization, 86, 317-319. - PubMed
  8. Andrews, S.J., Lamb, M.E., & Lyon, T.D. (2015). The effects of question repetition on responses when prosecutors and defense attorneys question children alleging sexual abuse in court. Law and Human Behavior, 39, 559-570. - PubMed
  9. Appleton, A., Holdsworth, E., Ryan, M., & Tracy, M. (2017). Measuring childhood adversity in life course cardiovascular research: a systematic review. Psychosomatic Medicine, 79, 434-440. - PubMed
  10. Baldwin, J.R., Reuben, A., Newbury, J.B., & Danese, A. (2019). Agreement between prospective and retrospective measures of childhood maltreatment. JAMA Psychiatry, 76, 584-593. - PubMed
  11. Barrett, W. (2018). Childhood trauma: Why I worry about the ACE-aware movement’s impact | Tes News. Available from: https://www.tes.com/news/why-i-worry-about-ace-aware-movements-impact [last accessed 15 October 2018]. - PubMed
  12. Belsky, J., Schlomer, G.L., & Ellis, B.J. (2012). Beyond cumulative risk: Distinguishing harshness and unpredictability as determinants of parenting and early life history strategy. Developmental Psychology, 48, 662-673. - PubMed
  13. Bennett, E.L., Rosenzweig, M.R., Diamond, M.C., Morimoto, H., & Hebert, M. (1974). Effects of successive environments on brain measures. Physiology and Behavior, 12, 621-631. - PubMed
  14. Berliner, L., & Kolko, D.J. (2016). Trauma Informed Care. Child Maltreatment, 21, 168-172. - PubMed
  15. Bethell, C.D., Carle, A., Hudziak, J., Gombojav, N., Powers, K., Wade, R., & Braveman, P. (2017). Methods to assess adverse childhood experiences of children and families: toward approaches to promote child well-being in policy and practice. Academic Pediatrics, 17, S51-S69. - PubMed
  16. Björkenstam, E., Hjern, A., & Vinnerljung, B. (2017). Adverse childhood experiences and disability pension in early midlife: results from a Swedish National Cohort Study. The European Journal of Public Health, 27, 472-477. - PubMed
  17. Bronfenbrenner, U. (1979). The ecology of human development. Cambridge, MA: Harvard University Press. - PubMed
  18. Brown, S., Rienks, S., McCrae, J., & Watamura, S. (2017). The co-occurrence of adverse childhood experiences among children investigated for child maltreatment: A latent class analysis. Child Abuse and Neglect, 87, 18-27. - PubMed
  19. Brumley, L.D., Brumley, B.P., & Jaffee, S.R. (2018). Comparing cumulative index and factor analytic approaches to measuring maltreatment in the National Longitudinal Study of Adolescent to Adult Health. Child Abuse and Neglect, 87, 65-76. - PubMed
  20. Bucci, M., Gutierrez Wang, L., Koita, K., Purewal, S., Silverio Marques, S., & Burke Harris, N. (2015). Center for Youth Wellness ACE-Questionnaire User Guide. San Francisco. Available from: http://centerforyouthwellness.org/wp-content/uploads/2018/06/CYW-ACE-Q-USer-Guide-copy.pdf [last accessed 27 September 2018]. - PubMed
  21. Busso, D.S., McLaughlin, K.A., & Sheridan, M.A. (2016). Dimensions of adversity, physiological reactivity, and externalizing psychopathology in adolescence: Deprivation and threat. Psychosomatic Medicine, 79, 162-171. - PubMed
  22. Caleyachetty, R., Hardy, R., Cooper, R., Richards, M., Howe, L.D., Anderson, E., … & Stafford, M. (2018). Modeling exposure to multiple childhood social risk factors and physical capability and common affective symptoms in later life. Journal of Aging and Health, 30, 386-407. - PubMed
  23. Caleyachetty, R., Khaw, K.-T., Surtees, P.G., Wainwright, N.W.J., Wareham, N., & Griffin, S.J. (2016). Cumulative social risk exposure in childhood and smoking and excessive alcohol use in adulthood. European Journal of Public Health, 26, 575-581. - PubMed
  24. Center for Youth Wellness (2017). Applying universal ACEs screening in the pediatric clinic. Available from: https://centerforyouthwellness.org/advancing-clinical-practice/ [last accessed 26 September 2018]. - PubMed
  25. Chapman, D., Whitfield, C., Felitti, V., Dube, S., Edwards, V., & Anda, R. (2004). Adverse childhood experiences and the risk of depressive disorders in adulthood. Journal of Affective Disorders, 82, 217-225. - PubMed
  26. Children1st (2018). Poverty and Adverse Childhood Experiences (ACEs). Available from: https://www.children1st.org.uk/who-we-are/news/blog/poverty-and-adverse-childhood-experiences-aces/ [last accessed 28 August 2019]. - PubMed
  27. Cohen, J.A., & Mannarino, A.P. (2008). Trauma-focused cognitive behavioural therapy for children and parents. Child and Adolescent Mental Health, 13, 158-162. - PubMed
  28. Couper, S., & Mackie, P. (2016). Scottish Public Health Network (ScotPHN) “Polishing the Diamonds” Addressing Adverse Childhood Experiences in Scotland. Available from: https://www.scotphn.net/wp-content/uploads/2016/06/2016_05_26-ACE-Report-Final-AF.pdf [last accessed 4 January 2018]. - PubMed
  29. Croen, L.A., Zerbo, O., Qian, Y., Massolo, M.L., Rich, S., Sidney, S., & Kripke, C. (2015). The health status of adults on the autism spectrum. Autism, 19, 814-23. - PubMed
  30. Cronholm, P.F., Forke, C.M., Wade, R., Bair-Merritt, M.H., Davis, M., Harkins-Schwarz, M., … & Fein, J.A. (2015). Adverse Childhood Experiences: expanding the concept of adversity. American Journal of Preventive Medicine, 49, 354-361. - PubMed
  31. Crowell, J.A., Davis, C.R., Joung, K.E., Usher, N., McCormick, S.P., Dearing, E., & Mantzoros, C.S. (2016). Metabolic pathways link childhood adversity to elevated blood pressure in midlife adults. Obesity Research and Clinical Practice, 10, 580-588. - PubMed
  32. Dalsgaard, S., Ostergaard, S.D., Leckman, J.F., Mortensen, P.B., & Pedersen, M.G. (2015). Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: A nationwide cohort study. The Lancet, 385, 2190-6. - PubMed
  33. Danese, A., Moffitt, T.E., Arseneault, L., Bleiberg, B.A., Dinardo, P.B., Gandelman, S.B., … & Caspi, A. (2017). The origins of cognitive deficits in victimized children: Implications for neuroscientists and clinicians. American Journal of Psychiatry, 174, 349-361. - PubMed
  34. Davis, C.R., Dearing, E., Usher, N., Trifiletti, S., Zaichenko, L., Ollen, E., … & Crowell, J.A. (2014). Detailed assessments of childhood adversity enhance prediction of central obesity independent of gender, race, adult psychosocial risk and health behaviors. Metabolism: Clinical and Experimental, 63, 199-206. - PubMed
  35. Debowska, A., Willmott, D., Boduszek, D., & Jones, A. (2017). What do we know about child abuse and neglect patterns of co-occurrence? A systematic review of profiling studies and recommendations for future research. Child Abuse and Neglect, 70, 100-111. - PubMed
  36. Denholm, R., Power, C., Thomas, C., & Li, L. (2013). Child maltreatment and household dysfunction in a British birth cohort. Child Abuse Review, 22, 340-353. - PubMed
  37. Dennison, M.J., Rosen, M.L., Sambrook, K.A., Jenness, J.L., Sheridan, M.A., & McLaughlin, K.A. (2017). Differential associations of distinct forms of childhood adversity with neurobehavioral measures of reward processing: A developmental pathway to depression. Child Development, 90, e96-e113. - PubMed
  38. Diamond, M.C., Rosenzweig, M.R., Bennett, E.L., Lindner, B., & Lyon, L. (1972). Effects of environmental enrichment and impoverishment on rat cerebral cortex. Journal of Neurobiology, 3, 47-64. - PubMed
  39. Dinkler, L., Lundström, S., Gajwani, R., Lichtenstein, P., Gillberg, C., & Minnis, H. (2017). Maltreatment-associated neurodevelopmental disorders: A co-twin control analysis. Journal of Child Psychology and Psychiatry, 58, 691-701. - PubMed
  40. Dong, M., Anda, R.F., Felitti, V.J., Dube, S.R., Williamson, D.F., Thompson, T.J., … & Giles, W.H. (2004). The interrelatedness of multiple forms of childhood abuse, neglect, and household dysfunction consequences of a specific ACE. Assessment of multiple ACEs allows for the potential assessment of a graded relationship between these childhood exposures and he. Child Abuse and Neglect, 28, 771-784. - PubMed
  41. Dube, S.R., Miller, J.W., Brown, D.W., Giles, W.H., Felitti, V.J., Dong, M., & Anda, R.F. (2006). Adverse childhood experiences and the association with ever using alcohol and initiating alcohol use during adolescence. The Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine, 38, 444, e1-10. - PubMed
  42. Dubowitz, H., Lane, W.G., Semiatin, J.N., & Magder, L.S. (2012). The SEEK model of pediatric primary care: Can child maltreatment be prevented in a low-risk population? Academic Pediatrics, 12, 259-268. - PubMed
  43. Edwards, R., Gillies, V., Lee, E., Macvarish, J., White, S., & Wastell, D. (2017). Written evidence submitted by Universities of Kent, Southampton, Sheffield, Westminster and Nottingham. Available from: http://data.parliament.uk/writtenevidence/committeeevidence.svc/evidencedocument/science-and-technology-committee/evidencebased-early-years-intervention/written/75249.html [last accessed 3 July 2019]. - PubMed
  44. Ellis, B.J., Figueredo, A.J., Brumbach, B.H., & Schlomer, G.L. (2009). Fundamental dimensions of environmental risk. Human Nature, 20, 204-268. - PubMed
  45. Evans, G.W., Li, D., & Whipple, S.S. (2013). Cumulative risk and child development. Psychological Bulletin, 139, 1342-1396. - PubMed
  46. Felitti, V., Anda, R.F., Nordenberg, D., Williamson, D.F., Spitz, A.M., Edwards, V., … & Marks, J.S. (1998). Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. American Journal of Preventive Medicine, 14, 245-258. - PubMed
  47. Finkelhor, D. (2018). Screening for adverse childhood experiences (ACEs): Cautions and suggestions. Child Abuse and Neglect, 85, 174-179. - PubMed
  48. Finkelhor, D., Ormrod, R.K., & Turner, H.A. (2007). Polyvictimization and trauma in a national longitudinal cohort. Development and Psychopathology, 19, 149-166. - PubMed
  49. Finkelhor, D., Shattuck, A., Turner, H., & Hamby, S. (2013). Improving the adverse childhood experiences study scale. JAMA Pediatrics, 167, 70-75. - PubMed
  50. Fletcher, S., Elklit, A., Shevlin, M., & Armour, C. (2017). Predictors of PTSD treatment response trajectories in a sample of childhood sexual abuse survivors: The roles of social support, coping, and PTSD symptom clusters. Journal of Interpersonal Violence. https://doi.org/10.1177/0886260517741212 - PubMed
  51. Fond, M., Haydon, A., & Kendall-Taylor, N. (2015). Communicating connections: Framing the relationship between social drivers, early adversity, and child neglect. Retrieved from: http://frameworksinstitute.org/assets/files/ECD/social_determinants_ecd_messagebrief_final.pdf [last accessed 20 February 2019]. - PubMed
  52. Ford, K.,Butler, N., Hughes, K., Quigg, Z., Bellis, M.A., Barker, P., … & Paterson, B. (2016). Adverse childhood experiences (ACEs) in hertfordshire, Luton and northamptonshire adverse childhood experiences (ACEs) in hertfordshire, Luton and Northamptonshire contributorship. Liverpool. - PubMed
  53. Ford, K., Hughes, K., Hardcastle, K., Di Lemma, L.C.G., Davies, A.R., Edwards, S., & Bellis, M.A. (2019). The evidence base for routine enquiry into adverse childhood experiences: A scoping review. Child Abuse and Neglect, 91, 131-146. - PubMed
  54. Ford, S., Merrick, M.T., Parks, S.E., Breiding, M.J., Gilbert, L.K., Edwards, V.J., … & Thompson, W.W. (2014). Examination of the factorial structure of adverse childhood experiences and recommendations for three subscale scores. Psychology of Violence, 4, 432-444. - PubMed
  55. Friedman, E.M., Montez, J.K., Sheehan, C.M., Guenewald, T.L., & Seeman, T.E. (2015). Childhood adversities and adult cardiometabolic health: Does the quantity, timing, and type of adversity matter? Journal of Aging and Health, 27, 1311-1338. - PubMed
  56. Green, J.G., McLaughlin, K.A., Berglund, P.A., Gruber, M.J., Sampson, N.A., Zaslavsky, A.M., & Kessler, R.C. (2010). Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: Associations with first onset of DSM-IV disorders. Archives of General Psychiatry, 67, 113-123. - PubMed
  57. Hamby, S., & Grych, J. (2013). The web of violence: Exploring connections among different forms of interpersonal violence and abuse. Dordrecht, the Netherlands. Springer. - PubMed
  58. Hartas, D. (2019). Assessing the foundational studies on adverse childhood experiences. Social Policy and Society, 18, 435-443. - PubMed
  59. Hirvikoski, T., Mittendorfer-Rutz, E., Boman, M., Larsson, H., Lichtenstein, P., & Bölte, S. (2016). Premature mortality in autism spectrum disorder. British Journal of Psychiatry, 208, 232-238. - PubMed
  60. Holmes, T.H., & Rahe, R.H. (1967). The social readjustment rating scale. Journal of Psychosomatic Research, 11, 213-218. - PubMed
  61. Howard, L.M. (2017). Routine enquiry about violence and abuse is needed for all mental health patients. British Journal of Psychiatry, 210, 298. - PubMed
  62. Howe, L.D., Tilling, K., & Lawlor, D.A. (2015). Studying the life course health consequences of childhood adversity: Challenges and opportunities. Circulation, 136(12), 1645-1647. - PubMed
  63. Hughes, K., Bellis, M.A., Hardcastle, K.A., Sethi, D., Butchart, A., Mikton, C., … & Dunne, M.P. (2017). The effect of multiple adverse childhood experiences on health: A systematic review and meta-analysis. The Lancet Public Health, 2, e356-e366. - PubMed
  64. Isohookana, R., Marttunen, M., Hakko, H., Riipinen, P., & Riala, K. (2016). The impact of adverse childhood experiences on obesity and unhealthy weight control behaviors among adolescents. Comprehensive Psychiatry, 71, 17-24. - PubMed
  65. Kajeepeta, S., Gelaye, B., Jackson, C.L., & Williams, M.A. (2015). Adverse childhood experiences are associated with adult sleep disorders: A systematic review. Sleep Medicine, 16, 320-330. - PubMed
  66. Kelly-Irving, M., & Delpierre, C. (2019). A critique of the adverse childhood experiences framework in epidemiology and public health: Uses and misuses. Social Policy and Society, 18, 445-456. - PubMed
  67. Kelly-Irving, M., Lepage, B., Dedieu, D., Bartley, M., Blane, D., Grosclaude, P., … & Delpierre, C. (2013). Adverse childhood experiences and premature all-cause mortality. European Journal of Epidemiology, 28, 721-734. - PubMed
  68. Ko, S.J., Ford, J.D., Kassam-Adams, N., Berkowitz, S.J., Wilson, C., Wong, M., … & Layne, C.M. (2008). Creating trauma-informed systems: Child welfare, education, first responders, health care, juvenile justice. Professional Psychology: Research and Practice, 39, 396-404. - PubMed
  69. Lanier, P., Maguire-Jack, K., Lombardi, B., Frey, J., & Rose, R.A. (2018). Adverse childhood experiences and child health outcomes: Comparing cumulative risk and latent class approaches. Maternal and Child Health Journal, 22, 288-297. - PubMed
  70. Liming, K.W. (2018). Examining the differing effects of economic hardship and poor maternal wellbeing on cumulative exposure to adverse childhood experiences. Journal of Child and Adolescent Trauma, 12, 307-321. - PubMed
  71. Maclean, M., Sims, S., Hansen, M., Leonard, H., Bourke, J., Bower, C., & O’Donnell, M. (2017). Abuse and neglect in children with disabilities: Risk varies by type of disability. International Journal of Population Data Science, 1, 177. - PubMed
  72. McEwen, C.A., & Gregerson, S.F. (2019). A Critical assessment of the adverse childhood experiences study at 20 years. American Journal of Preventive Medicine, 56, 790-794. - PubMed
  73. McGuire, A., Cho, B., Huffhines, L., Gusler, S., Brown, S., & Jackson, Y. (2018). The relation between dimensions of maltreatment, placement instability, and mental health among youth in foster care. Child Abuse and Neglect, 86, 10-21. - PubMed
  74. McLaughlin, K.A. (2016). Future directions in childhood adversity and youth psychopathology. Journal of Clinical Child and Adolescent Psychology, 45, 361-382. - PubMed
  75. McLaughlin, K.A., & Sheridan, M.A. (2016). Beyond cumulative risk: A dimensional approach to childhood adversity. Current Directions in Psychological Science, 25, 239-245. - PubMed
  76. McLaughlin, K.A., Sheridan, M.A., & Lambert, H.K. (2014). Childhood adversity and neural development: Deprivation and threat as distinct dimensions of early experience. Neuroscience and Biobehavioral Reviews, 47, 578-591. - PubMed
  77. Merrick, M., Ports, K., Ford, D., Afifi, T., Gershoff, E., & Grogan-Kaylor, A. (2017). Unpacking the impact of adverse childhood experiences on adult mental health. Child Abuse and Neglect, 69, 10-19. - PubMed
  78. Mersky, J.P., Janczewski, C.E., & Topitzes, J. (2017). Rethinking the measurement of adversity. Child Maltreatment, 22, 58-68. - PubMed
  79. Miller, A.B., Sheridan, M.A., Hanson, J.L., McLaughlin, K.A., Bates, J.E., Lansford, J.E., … & Dodge, K.A. (2018). Dimensions of deprivation and threat, psychopathology, and potential mediators: A multi-year longitudinal analysis. Journal of Abnormal Psychology, 127, 160-170. - PubMed
  80. Nemeroff, C.B., & Binder, E. (2014). The preeminent role of childhood abuse and neglect in vulnerability to major psychiatric disorders: toward elucidating the underlying neurobiological mechanisms. Journal of the American Academy of Child and Adolescent Psychiatry, 53, 395-397. - PubMed
  81. Newbury, J., Arseneault, L., Moffitt, T., Caspi, A., Danese, A., Baldwin, J., & Fisher, H. (2018). Measuring childhood maltreatment to predict early-adult psychopathology: Comparison of prospective informant-reports and retrospective self-reports. Journal of Psychiatric Research, 96, 57-64. - PubMed
  82. NHS Highlands (2018). Adverse Childhood Experiences, Resilience and Trauma Informed Care: A Public Health Approach to Understanding and Responding to Adversity. Available from: https://www.nhshighland.scot.nhs.uk/Publications/Documents/DPH-Annual-Report-2018_(web-version).pdf [last accessed 20 February 2019]. - PubMed
  83. PublicHealthWales (n.d.). Adverse childhood experiences video. Available from: http://www.aces.me.uk/in-wales/ [last accessed 20 February 2019]. - PubMed
  84. Purewal, S., Bucci, M., Wang, L., Koita, K., Marques, S., Oh, D., & Burke Harris, N. (2016). Screening for Adverse Childhood Experiences (ACEs) in an integrated pediatric care model. Zero to Three, 37, 10-17. - PubMed
  85. Read, J., Harper, D., Tucker, I., & Kennedy, A. (2018). Do adult mental health services identify child abuse and neglect? A systematic review. International Journal of Mental Health Nursing, 27, 7-19. - PubMed
  86. RealLifeResearch (2015). An Evaluation of REACh: Routine enquiry into adversity in childhood. Available from: https://warrenlarkinassociates.co.uk/media/1261/july29-final-full-evaluation-report-for-reach-1.pdf [last accessed 20 February 2019]. - PubMed
  87. Reuben, A., Moffitt, T.E., Caspi, A., Belsky, D.W., Harrington, H., Schroeder, F., … & Danese, A. (2016). Lest we forget: comparing retrospective and prospective assessments of adverse childhood experiences in the prediction of adult health. Journal of Child Psychology and Psychiatry, 57, 1103-1112. - PubMed
  88. Ross, C.E., & Mirowsky, J. (1979). A comparison of life-event-weighting schemes: Change, undesirability, and effect-proportional indices. Journal of Health and Social Behavior, 20(2), 166. - PubMed
  89. Rutter, M. (1978). Family, area and school influences in the genesis of conduct disorders. In L.A. Hersov, & M. Berger (Eds.), Aggression and anti-social behavior in childhood and adolescence (pp. 95-113). Oxford, UK: Pergamon. - PubMed
  90. Sameroff, A.J., Seifer, R., Zax, M., & Barocas, R. (1987). Early indicators of developmental risk: Rochester longitudinal study. Schizophrenia Bulletin, 13, 383-394. - PubMed
  91. Schooling, C.M., Jiang, C., Lam, T.H., Zhang, W., Cheng, K.K., & Leung, G.M. (2011). Parental death during childhood and adult cardiovascular risk in a developing country: The Guangzhou Biobank Cohort study. PLoS ONE, 6, e19675. - PubMed
  92. Slopen, N., Koenen, K.C., & Kubzansky, L.D. (2014). Cumulative adversity in childhood and emergent risk factors for long-term health. The Journal of Pediatrics, 164, 631-638. e2. - PubMed
  93. Slopen, N., Loucks, E.B., Appleton, A.A., Kawachi, I., Kubzansky, L.D., Non, A.L., … & Gilman, S.E. (2015). Early origins of inflammation: An examination of prenatal and childhood social adversity in a prospective cohort study. Psychoneuroendocrinology, 51, 403-413. - PubMed
  94. Stern, A., Agnew-Blais, J., Danese, A., Fisher, H.L., Jaffee, S.R., Matthews, T., … & Arseneault, L. (2018). Associations between abuse/neglect and ADHD from childhood to young adulthood: A prospective nationally-representative twin study. Child Abuse and Neglect, 81, 274-285. - PubMed
  95. Sullivan, K.M., Murray, K.J., & Ake, G.S. (2016). Trauma-informed care for children in the child welfare system. Child Maltreatment, 21, 147-155. - PubMed
  96. Sumner, J.A., Colich, N.L., Uddin, M., Armstrong, D., & McLaughlin, K.A. (2018). Early experiences of threat, but not deprivation, are associated with accelerated biological aging in children and adolescents. Biological Psychiatry, 85, 268-278. - PubMed
  97. Taket, A., Wathen, C.N., & MacMillan, H. (2004). Should health professionals screen all women for domestic violence? PLoS Med, 1, e4. - PubMed
  98. van der Kolk, B.A. (2005). Developmental trauma disorder: Toward a rational diagnosis for children with complex trauma histories. Psychiatric Annals, 35, 401-408. - PubMed
  99. van Marle, H.J.F., Hermans, E.J., Qin, S., & Fernández, G. (2009). From specificity to sensitivity: how acute stress affects amygdala processing of biologically salient stimuli. Biological Psychiatry, 66, 649-655. - PubMed
  100. Werner, E., & Smith, R. (1982). Vulnerable but invincible: A longitudinal study of resilient children and youth. New York: McGraw Hil. - PubMed
  101. Westermair, A.L., Stoll, A.M., Greggersen, W., Kahl, K.G., Hüppe, M., & Schweiger, U. (2018). All unhappy childhoods are unhappy in their own way - Differential impact of dimensions of adverse childhood experiences on adult mental health and health behavior. Frontiers in Psychiatry, 9, 198. - PubMed
  102. WHO (2018). Adverse Childhood Experiences International Questionnaire (ACE-IQ). Available from: http://www.who.int/violence_injury_prevention/violence/activities/adverse_childhood_experiences/en/ [last accessed 4 February 2015]. - PubMed
  103. Wilson, J.M.G., & Jungner, G. (1968). Principles and practice of screening for disease. Geneva. Available from: https://apps.who.int/iris/bitstream/handle/10665/37650/WHO_PHP_34.pdf?sequence=17&isAllowed=y [last accessed 22 February 2018]. - PubMed

MeSH terms

Publication Types