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Front Microbiol. 2019 Aug 28;10:1995. doi: 10.3389/fmicb.2019.01995. eCollection 2019.

Microtiter Screening Reveals Oxygen-Dependent Antimicrobial Activity of Natural Products Against Mastitis-Causing Bacteria.

Frontiers in microbiology

Scott A Ferguson, Ayana Menorca, Essie M Van Zuylen, Chen-Yi Cheung, Michelle A McConnell, David Rennison, Margaret A Brimble, Kip Bodle, Scott McDougall, Gregory M Cook, Adam Heikal

Affiliations

  1. Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
  2. School of Chemical Sciences, The University of Auckland, Auckland, New Zealand.
  3. Deosan Ltd., Waharoa, New Zealand.
  4. Cognosco, Anexa FVC, Morrinsville, New Zealand.

PMID: 31555233 PMCID: PMC6722467 DOI: 10.3389/fmicb.2019.01995

Abstract

In this study we investigated the influence of oxygen availability on a phenotypic microtiter screen to identify new, natural product inhibitors of growth for the bovine mastitis-causing microorganisms;

Keywords: Staphylococcus aureus; Streptococcus uberis; antimicrobial; mastitis; natural product inhibitors; oxygen-dependent; β-lapachone

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