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Passariello A, Errico ME, Donofrio V, et al. PATZ1 Is Overexpressed in Pediatric Glial Tumors and Correlates with Worse Event-Free Survival in High-grade Gliomas. Cancers (Basel). 2019;11(10)doi: 10.3390/cancers11101537.
Passariello, A., Errico, M. E., Donofrio, V., Maestrini, M., Zerbato, A., Cerchia, L., Capasso, M., Capasso, M., & Fedele, M. (2019). PATZ1 Is Overexpressed in Pediatric Glial Tumors and Correlates with Worse Event-Free Survival in High-grade Gliomas. Cancers, 11(10), . https://doi.org/10.3390/cancers11101537
Passariello, Annalisa, et al. "PATZ1 Is Overexpressed in Pediatric Glial Tumors and Correlates with Worse Event-Free Survival in High-grade Gliomas." Cancers vol. 11,10 (2019). doi: https://doi.org/10.3390/cancers11101537
Passariello A, Errico ME, Donofrio V, Maestrini M, Zerbato A, Cerchia L, Capasso M, Capasso M, Fedele M. PATZ1 Is Overexpressed in Pediatric Glial Tumors and Correlates with Worse Event-Free Survival in High-grade Gliomas. Cancers (Basel). 2019 Oct 11;11(10). doi: 10.3390/cancers11101537. PMID: 31614588; PMCID: PMC6826955.
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Cancers (Basel). 2019 Oct 11;11(10). doi: 10.3390/cancers11101537.

PATZ1 Is Overexpressed in Pediatric Glial Tumors and Correlates with Worse Event-Free Survival in High-grade Gliomas.

Cancers

Annalisa Passariello, Maria Elena Errico, Vittoria Donofrio, Manuela Maestrini, Alia Zerbato, Laura Cerchia, Maria Capasso, Mario Capasso, Monica Fedele

Affiliations

  1. Department of Pediatric Oncology, Santobono-Pausilipon Hospital, 80123 Naples, Italy. [email protected].
  2. Department of Translational Medical Science Pediatric Section, University of Naples Federico II, 80131 Naples, Italy. [email protected].
  3. Pathology Unit, Santobono-Pausilipon Hospital, 80123 Naples, Italy. [email protected].
  4. Pathology Unit, Santobono-Pausilipon Hospital, 80123 Naples, Italy. [email protected].
  5. Department of Translational Medical Science Pediatric Section, University of Naples Federico II, 80131 Naples, Italy. [email protected].
  6. Department of Translational Medical Science Pediatric Section, University of Naples Federico II, 80131 Naples, Italy. [email protected].
  7. National Research Council (CNR), Institute of Experimental Endocrinology and Oncology "G. Salvatore" (IEOS), 80145 Naples, Italy. [email protected].
  8. Department of Pediatric Oncology, Santobono-Pausilipon Hospital, 80123 Naples, Italy. [email protected].
  9. CEINGE Biotecnologie avanzate, 80145 Naples, Italy. [email protected].
  10. Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy. [email protected].
  11. National Research Council (CNR), Institute of Experimental Endocrinology and Oncology "G. Salvatore" (IEOS), 80145 Naples, Italy. [email protected].

PMID: 31614588 PMCID: PMC6826955 DOI: 10.3390/cancers11101537

Abstract

Glial tumors are the leading cause of cancer-related death and morbidity in children. Their diagnosis, mainly based on clinical and histopathological factors, is particularly challenging because of their high molecular heterogeneity. Thus, tumors with identical histotypes could result in variable biological behaviors and prognoses. The PATZ1 gene has been recently shown to be expressed in adult gliomas, including glioblastomas, where it correlates with the proneural subtype and with a better prognosis. Here, we analyzed the expression of PATZ1 in pediatric gliomas, first at mRNA level in a public database, and then at protein level, by immunohistochemistry, in a cohort of 52 glial brain tumors from young patients aged from 6 months to 16 years. As for adult tumors, we show that PATZ1 is enriched in glial tumors compared to the normal brain, where it correlates positively and negatively with a proneural and mesenchymal signature, respectively. Moreover, we show that PATZ1 is expressed at variable levels in our cohort of tumors. Higher expression was detected in high-grade than low-grade gliomas, suggesting a correlation with the malignancy. Among high-grade gliomas, higher levels of PATZ1 have consistently been found to correlate with worse event-free survival. Therefore, our study may imply new diagnostic opportunities for pediatric gliomas.

Keywords: PATZ1; glioma; pediatric brain tumors; prognosis

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