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Pietrocola F, Kroemer G. Caloric restriction promotes the stemness and antitumor activity of T lymphocytes. Oncoimmunology. 2019;8(10):e1616153doi: 10.1080/2162402X.2019.1616153.
Pietrocola, F., & Kroemer, G. (2019). Caloric restriction promotes the stemness and antitumor activity of T lymphocytes. Oncoimmunology, 8(10), e1616153. https://doi.org/10.1080/2162402X.2019.1616153
Pietrocola, Federico, and Kroemer, Guido. "Caloric restriction promotes the stemness and antitumor activity of T lymphocytes." Oncoimmunology vol. 8,10 (2019): e1616153. doi: https://doi.org/10.1080/2162402X.2019.1616153
Pietrocola F, Kroemer G. Caloric restriction promotes the stemness and antitumor activity of T lymphocytes. Oncoimmunology. 2019 May 16;8(10):e1616153. doi: 10.1080/2162402X.2019.1616153. eCollection 2019. PMID: 31646069; PMCID: PMC6791451.
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Oncoimmunology. 2019 May 16;8(10):e1616153. doi: 10.1080/2162402X.2019.1616153. eCollection 2019.

Caloric restriction promotes the stemness and antitumor activity of T lymphocytes.

Oncoimmunology

Federico Pietrocola, Guido Kroemer

Affiliations

  1. Institute for Research in Biomedicine, Barcelona, Spain.
  2. INSERM, U1138, Paris, France.
  3. Gustave Roussy Cancer Campus, Villejuif, France.
  4. Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.
  5. Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France.
  6. Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France.
  7. Université Pierre et Marie Curie, Paris, France.
  8. Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
  9. Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.

PMID: 31646069 PMCID: PMC6791451 DOI: 10.1080/2162402X.2019.1616153

Abstract

Recent findings have shed new light on the mechanisms through which tumor-infiltrating lymphocytes (TILs) maintain their cytotoxic potential in the context of checkpoint blockade or adoptive transfer therapies. As a consequence of the ionic unbalance occurring in the tumor microenvironment, TILs enter an adaptive caloric-restricted state, characterized by a decline in nucleocytosolic acetyl CoA levels and induction of autophagy. These events dictate an epigenetic program that drives the acquisition of a stem-cell-like phenotype and ultimately improves antitumor function. These findings open the way to novel anticancer therapies based on the induction of autophagy by pharmacological caloric restriction mimetics.

© 2019 Taylor & Francis Group, LLC.

Keywords: Autophagy; aging; hydroxycitrate; immune checkpoints; immunometabolism; longevity; methionine

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