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Eriksen R, Gibson R, Aresu M, et al. Gene-diet quality interactions on haemoglobin A1c and type 2 diabetes risk: The Airwave Health Monitoring Study. Endocrinol Diabetes Metab. 2019;2(4):e00074doi: 10.1002/edm2.74.
Eriksen, R., Gibson, R., Aresu, M., Heard, A., Chan, Q., Evangelou, E., Gao, H., Elliott, P., & Frost, G. (2019). Gene-diet quality interactions on haemoglobin A1c and type 2 diabetes risk: The Airwave Health Monitoring Study. Endocrinology, diabetes & metabolism, 2(4), e00074. https://doi.org/10.1002/edm2.74
Eriksen, Rebeca, et al. "Gene-diet quality interactions on haemoglobin A1c and type 2 diabetes risk: The Airwave Health Monitoring Study." Endocrinology, diabetes & metabolism vol. 2,4 (2019): e00074. doi: https://doi.org/10.1002/edm2.74
Eriksen R, Gibson R, Aresu M, Heard A, Chan Q, Evangelou E, Gao H, Elliott P, Frost G. Gene-diet quality interactions on haemoglobin A1c and type 2 diabetes risk: The Airwave Health Monitoring Study. Endocrinol Diabetes Metab. 2019 Jul 11;2(4):e00074. doi: 10.1002/edm2.74. eCollection 2019 Oct. PMID: 31592155; PMCID: PMC6775444.
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Endocrinol Diabetes Metab. 2019 Jul 11;2(4):e00074. doi: 10.1002/edm2.74. eCollection 2019 Oct.

Gene-diet quality interactions on haemoglobin A1c and type 2 diabetes risk: The Airwave Health Monitoring Study.

Endocrinology, diabetes & metabolism

Rebeca Eriksen, Rachel Gibson, Maria Aresu, Andy Heard, Queenie Chan, Evangelos Evangelou, He Gao, Paul Elliott, Gary Frost

Affiliations

  1. Nutrition and Dietetic Research Group, Faculty of Medicine Imperial College London UK.
  2. Department of Nutritional Sciences, School of Life Course Sciences King's College London London UK.
  3. Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health Imperial College London UK.

PMID: 31592155 PMCID: PMC6775444 DOI: 10.1002/edm2.74

Abstract

INTRODUCTION: Type 2 diabetes (T2D) is multifactorial involving lifestyle, environmental and genetic risk factors. This study aims to investigate the impact of genetic interactions with alcohol and diet quality on glycated haemoglobin A1c (HbA1c) independent of obesity, in a British population.

METHODS: Cross-sectional study of 14 089 white British participants from Airwave Health Monitoring Study and a subsample of 3733 participants with dietary data. A T2D genetic risk score (GRS) was constructed, and its interactions with diet on HbA1c were assessed.

RESULTS: GRS was associated with a higher HbA1c% (

CONCLUSION: The genetic effect on HbA1c was almost doubled in obese individuals, compared with those with a healthy weight, and independent of weight, there was a modest offset on HbA1c in high-genetic-risk individuals consuming a diet high in wholegrain. This supports the importance of a healthy diet high in wholegrains and along with maintaining a healthy weight in controlling HbA1c among high-genetic-risk groups.

© 2019 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.

Keywords: diet; genetic risk; type 2 diabetes

Conflict of interest statement

None to declare.

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