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Wang C, Gong S, Liang Z, et al. Ligand-Promoted Iridium-Catalyzed Transfer Hydrogenation of Terminal Alkynes with Ethanol and Its Application. ACS Omega. 2019;4(14):16045-16051doi: 10.1021/acsomega.9b02191.
Wang, C., Gong, S., Liang, Z., Sun, Y., Cheng, R., Yang, B., Liu, Y., Yang, J., & Sun, F. (2019). Ligand-Promoted Iridium-Catalyzed Transfer Hydrogenation of Terminal Alkynes with Ethanol and Its Application. ACS omega, 4(14), 16045-16051. https://doi.org/10.1021/acsomega.9b02191
Wang, Chengniu, et al. "Ligand-Promoted Iridium-Catalyzed Transfer Hydrogenation of Terminal Alkynes with Ethanol and Its Application." ACS omega vol. 4,14 (2019): 16045-16051. doi: https://doi.org/10.1021/acsomega.9b02191
Wang C, Gong S, Liang Z, Sun Y, Cheng R, Yang B, Liu Y, Yang J, Sun F. Ligand-Promoted Iridium-Catalyzed Transfer Hydrogenation of Terminal Alkynes with Ethanol and Its Application. ACS Omega. 2019 Sep 18;4(14):16045-16051. doi: 10.1021/acsomega.9b02191. eCollection 2019 Oct 01. PMID: 31592175; PMCID: PMC6777128.
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ACS Omega. 2019 Sep 18;4(14):16045-16051. doi: 10.1021/acsomega.9b02191. eCollection 2019 Oct 01.

Ligand-Promoted Iridium-Catalyzed Transfer Hydrogenation of Terminal Alkynes with Ethanol and Its Application.

ACS omega

Chengniu Wang, Shengnan Gong, Zhipeng Liang, Yufeng Sun, Rui Cheng, Banghua Yang, Yirong Liu, Jinfei Yang, Fei Sun

Affiliations

  1. Medical School, Institute of Reproductive Medicine, Nantong University, Nantong 226019, China.

PMID: 31592175 PMCID: PMC6777128 DOI: 10.1021/acsomega.9b02191

Abstract

A ligand-promoted iridium-catalyzed transfer hydrogenation of terminal alkynes with ethanol and its application has been developed. Highly chemical selectivity control is achieved based on ligand regulation. 1,2-Bis(diphenylphosphino)ethane was found to be critical for the transfer hydrogenation of alkynes. The general applicability of this procedure is highlighted by the synthesis of 30 terminal alkenes with a good yield. In addition, we conducted drug effect studies of phenelzine using zebrafish as the vertebrate model. Phenelzine shows a significant effect on promoting vascular proliferation and inhibiting nerve growth. The results of these studies have an important reference value for promoting drug research in cerebrovascular diseases, epilepsy, mania, and psychosis.

Copyright © 2019 American Chemical Society.

Conflict of interest statement

The authors declare no competing financial interest.

References

  1. Chem Commun (Camb). 2015 Feb 11;51(12):2384-7 - PubMed
  2. Org Lett. 2019 Mar 1;21(5):1412-1416 - PubMed
  3. J Org Chem. 2010 May 7;75(9):2966-70 - PubMed
  4. J Am Chem Soc. 2018 Mar 28;140(12):4417-4429 - PubMed
  5. Angew Chem Int Ed Engl. 2008;47(17):3245-9 - PubMed
  6. J Org Chem. 2015 Jan 16;80(2):847-51 - PubMed
  7. Chem Rev. 2015 Jul 8;115(13):6621-86 - PubMed
  8. Angew Chem Int Ed Engl. 2008;47(17):3223-6 - PubMed
  9. Chem Rev. 2013 Mar 13;113(3):1313-50 - PubMed
  10. J Am Chem Soc. 2012 Oct 24;134(42):17536-42 - PubMed
  11. Tetrahedron. 2018 May 24;74(21):2547-2560 - PubMed
  12. J Am Chem Soc. 2008 Mar 19;130(11):3690-704 - PubMed
  13. J Am Chem Soc. 2011 Oct 26;133(42):17037-44 - PubMed
  14. Chemistry. 2009;15(15):3889-99 - PubMed
  15. J Am Chem Soc. 2010 Dec 1;132(47):16900-10 - PubMed
  16. Nat Prod Rep. 2003 Dec;20(6):558-64 - PubMed
  17. Br J Psychiatry. 1987 Nov;151:639-42 - PubMed
  18. Nat Rev Drug Discov. 2006 Jun;5(6):493-506 - PubMed
  19. Chem Commun (Camb). 2012 May 18;48(40):4827-9 - PubMed
  20. Chemistry. 2013 Dec 16;19(51):17603-7 - PubMed
  21. Mol Endocrinol. 2012 May;26(5):716-35 - PubMed
  22. Chemistry. 2011 Jul 18;17(30):8462-5 - PubMed
  23. Dalton Trans. 2019 Apr 2;48(14):4474-4478 - PubMed
  24. Tetrahedron. 2010 Jan 30;66(5):1102-1110 - PubMed
  25. J Am Chem Soc. 2018 Aug 15;140(32):10126-10130 - PubMed
  26. J Psychiatr Pract. 2004 Jul;10(4):239-48 - PubMed
  27. AAPS J. 2006 Apr 14;8(2):E239-53 - PubMed
  28. J Am Chem Soc. 2019 Jan 9;141(1):11-24 - PubMed
  29. J Med Chem. 2006 Jun 1;49(11):3033-44 - PubMed
  30. Chem Commun (Camb). 2015 May 4;51(36):7729-32 - PubMed
  31. Angew Chem Int Ed Engl. 2017 Jun 6;56(24):6984-6988 - PubMed
  32. Chemistry. 2010 Oct 25;16(40):12214-20 - PubMed
  33. Chem Rev. 2016 Aug 10;116(15):8318-72 - PubMed
  34. Chem Asian J. 2011 Jun 6;6(6):1613-23 - PubMed
  35. Chem Commun (Camb). 2019 Feb 7;55(13):1903-1906 - PubMed
  36. J Org Chem. 2007 Jan 5;72(1):144-9 - PubMed

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