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Wang W, Guo DY, Lin YJ, et al. Melanocortin Regulation of Inflammation. Front Endocrinol (Lausanne). 2019;10:683doi: 10.3389/fendo.2019.00683.
Wang, W., Guo, D. Y., Lin, Y. J., & Tao, Y. X. (2019). Melanocortin Regulation of Inflammation. Frontiers in endocrinology, 10683. https://doi.org/10.3389/fendo.2019.00683
Wang, Wei, et al. "Melanocortin Regulation of Inflammation." Frontiers in endocrinology vol. 10 (2019): 683. doi: https://doi.org/10.3389/fendo.2019.00683
Wang W, Guo DY, Lin YJ, Tao YX. Melanocortin Regulation of Inflammation. Front Endocrinol (Lausanne). 2019 Oct 09;10:683. doi: 10.3389/fendo.2019.00683. eCollection 2019. PMID: 31649620; PMCID: PMC6794349.
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Front Endocrinol (Lausanne). 2019 Oct 09;10:683. doi: 10.3389/fendo.2019.00683. eCollection 2019.

Melanocortin Regulation of Inflammation.

Frontiers in endocrinology

Wei Wang, Dong-Yu Guo, Yue-Jun Lin, Ya-Xiong Tao

Affiliations

  1. Department of Clinical Laboratory, Xiamen Huli Guoyu Clinic, Co., Ltd., Xiamen, China.
  2. Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States.

PMID: 31649620 PMCID: PMC6794349 DOI: 10.3389/fendo.2019.00683

Abstract

Adrenocorticotropic hormone (ACTH), and α-, β-, and γ-melanocyte-stimulating hormones (α-, β-, γ-MSH), collectively known as melanocortins, together with their receptors (melanocortin receptors), are components of an ancient modulatory system. The clinical use of ACTH in the treatment of rheumatoid arthritis started in 1949, originally thought that the anti-inflammatory action was through hypothalamus-pituitary-adrenal axis and glucocorticoid-dependent. Subsequent decades have witnessed extensive attempts in unraveling the physiology and pharmacology of the melanocortin system. It is now known that ACTH, together with α-, β-, and γ-MSHs, also possess glucocorticoid-independent anti-inflammatory and immunomodulatory effects by activating the melanocortin receptors expressed in the brain or peripheral immune cells. This review will briefly introduce the melanocortin system and highlight the action of melanocortins in the regulation of immune functions from

Copyright © 2019 Wang, Guo, Lin and Tao.

Keywords: immune modulation; melanocortin; melanocortin receptor; signaling; therapeutics

References

  1. J Immunol. 2003 Mar 15;170(6):3323-30 - PubMed
  2. Biochim Biophys Acta. 1996 Aug 28;1313(2):130-8 - PubMed
  3. J Leukoc Biol. 2000 Feb;67(2):233-9 - PubMed
  4. Physiol Rev. 2000 Jul;80(3):979-1020 - PubMed
  5. Kidney Int. 1998 Sep;54(3):765-74 - PubMed
  6. Curr Top Med Chem. 2007;7(11):1098-1106 - PubMed
  7. Eur J Immunol. 2006 Mar;36(3):754-69 - PubMed
  8. J Pharmacol Exp Ther. 2006 May;317(2):771-7 - PubMed
  9. Peptides. 1996;17(4):675-9 - PubMed
  10. Peptides. 2000 Oct;21(10):1473-7 - PubMed
  11. Eur J Pharmacol. 2011 Nov 30;670(2-3):479-86 - PubMed
  12. Peptides. 2005 Oct;26(10):1788-99 - PubMed
  13. Nature. 1979 Mar 29;278(5703):423-7 - PubMed
  14. J Immunol. 1998 Sep 15;161(6):2873-80 - PubMed
  15. J Leukoc Biol. 1998 Jun;63(6):740-5 - PubMed
  16. Biochim Biophys Acta Mol Basis Dis. 2017 Oct;1863(10 Pt A):2411-2413 - PubMed
  17. Proc Natl Acad Sci U S A. 1977 Jul;74(7):3014-8 - PubMed
  18. J Immunol. 1999 Jun 15;162(12):7446-53 - PubMed
  19. FASEB J. 2010 Dec;24(12):4835-43 - PubMed
  20. Am J Physiol. 1994 Feb;266(2 Pt 2):R614-21 - PubMed
  21. N Engl J Med. 1950 Nov 2;243(18):693-5 - PubMed
  22. FASEB J. 1989 Sep;3(11):2282-4 - PubMed
  23. Arch Intern Med (Chic). 1950 Apr;85(4):545-666 - PubMed
  24. Biochem J. 1998 Apr 1;331 ( Pt 1):211-6 - PubMed
  25. Peptides. 2009 Jun;30(6):1098-104 - PubMed
  26. Peptides. 2006 Feb;27(2):259-64 - PubMed
  27. J Leukoc Biol. 2001 Jan;69(1):98-104 - PubMed
  28. Ann N Y Acad Sci. 1999 Oct 20;885:277-86 - PubMed
  29. Neurochem Res. 1995 Jan;20(1):107-13 - PubMed
  30. Neuroimmunomodulation. 1999 May-Jun;6(3):187-92 - PubMed
  31. Proc Natl Acad Sci U S A. 1977 Nov;74(11):4826-30 - PubMed
  32. Glia. 2013 Aug;61(8):1206-17 - PubMed
  33. Ann N Y Acad Sci. 1993 May 31;680:567-70 - PubMed
  34. Basic Clin Pharmacol Toxicol. 2007 Dec;101(6):416-20 - PubMed
  35. Biochim Biophys Acta. 2016 Sep;1862(9):1485-94 - PubMed
  36. Clin Exp Immunol. 2001 Dec;126(3):441-6 - PubMed
  37. Peptides. 2006 Nov;27(11):2846-57 - PubMed
  38. Mol Endocrinol. 1994 Oct;8(10):1298-308 - PubMed
  39. J Pharmacol Exp Ther. 2003 Aug;306(2):631-7 - PubMed
  40. Adv Pharmacol. 2014;70:135-54 - PubMed
  41. J Neurosci Res. 2014 Oct;92(10):1243-51 - PubMed
  42. Endocrinology. 2006 Mar;147(3):1126-35 - PubMed
  43. PLoS One. 2013 Aug 05;8(8):e71056 - PubMed
  44. Endocr Rev. 2012 Aug;33(4):623-51 - PubMed
  45. Ann N Y Acad Sci. 1999 Oct 20;885:188-95 - PubMed
  46. Science. 1992 Aug 28;257(5074):1248-51 - PubMed
  47. Neuroimmunomodulation. 1994 May-Jun;1(3):188-94 - PubMed
  48. Urology. 2000 Oct 1;56(4):641-6 - PubMed
  49. Ann N Y Acad Sci. 1999 Oct 20;885:161-72 - PubMed
  50. Brain Res. 2004 Jan 2;995(1):7-13 - PubMed
  51. J Cell Physiol. 1998 Jun;175(3):276-82 - PubMed
  52. Neuroimmunomodulation. 1994 Jan;1(1):28-32 - PubMed
  53. Yale J Biol Med. 1990 Mar-Apr;63(2):173-82 - PubMed
  54. Cytokine. 1992 Jul;4(4):320-8 - PubMed
  55. Nat Neurosci. 2005 May;8(5):571-8 - PubMed
  56. FASEB J. 2008 Dec;22(12):4228-38 - PubMed
  57. Mol Cell Endocrinol. 2005 Jul 15;239(1-2):1-14 - PubMed
  58. J Neurosci. 1994 Apr;14(4):2377-82 - PubMed
  59. Endocrinology. 2008 Apr;149(4):1898-905 - PubMed
  60. J Neurosci Res. 1999 Dec 1;58(5):684-9 - PubMed
  61. Brain Res Mol Brain Res. 1999 Jan 8;63(2):276-86 - PubMed
  62. Ann N Y Acad Sci. 2000;917:239-47 - PubMed
  63. Peptides. 2008 Oct;29(10):1825-35 - PubMed
  64. Semin Immunol. 2015 May;27(3):216-26 - PubMed
  65. ScientificWorldJournal. 2010 Sep 14;10:1840-53 - PubMed
  66. J Invest Dermatol. 2002 Mar;118(3):533-9 - PubMed
  67. Pediatrics. 1996 Mar;97(3):375-9 - PubMed
  68. Regul Pept. 2006 Nov 15;137(1-2):58-66 - PubMed
  69. Biochem Mol Biol Int. 1996 Feb;38(1):73-80 - PubMed
  70. Regul Pept. 2007 Mar 1;139(1-3):115-21 - PubMed
  71. J Leukoc Biol. 2006 Oct;80(4):897-904 - PubMed
  72. Drug Des Devel Ther. 2011;5:381-9 - PubMed
  73. Peptides. 1981 Summer;2(2):177-87 - PubMed
  74. Br J Pharmacol. 2010 May;160(1):171-80 - PubMed
  75. Shock. 2004 Nov;22(5):453-9 - PubMed
  76. Transplant Proc. 2007 Jun;39(5):1604-6 - PubMed
  77. Mol Cell Endocrinol. 2009 May 6;303(1-2):74-81 - PubMed
  78. Acta Neuropathol. 2011 Oct;122(4):443-53 - PubMed
  79. Biopharm Drug Dispos. 1997 Apr;18(3):259-69 - PubMed
  80. Shock. 2007 Mar;27(3):326-33 - PubMed
  81. Arch Dermatol Res. 1998 Aug;290(8):425-8 - PubMed
  82. Nucleic Acids Res. 1984 Nov 12;12(21):8029-41 - PubMed
  83. J Leukoc Biol. 1996 Feb;59(2):248-53 - PubMed
  84. Immunol Cell Biol. 2001 Aug;79(4):358-67 - PubMed
  85. Osteoarthritis Cartilage. 2008 Jan;16(1):115-24 - PubMed
  86. Biochim Biophys Acta Mol Basis Dis. 2017 Oct;1863(10 Pt A):2486-2495 - PubMed
  87. Arthritis Rheum. 2002 Oct;46(10):2765-75 - PubMed
  88. FEBS Lett. 2003 Aug 14;549(1-3):87-93 - PubMed
  89. Ann N Y Acad Sci. 1994 Nov 25;741:137-48 - PubMed
  90. J Immunol. 2005 Oct 1;175(7):4806-13 - PubMed
  91. Biochem Biophys Res Commun. 1999 Sep 16;263(1):251-6 - PubMed
  92. Ann N Y Acad Sci. 2003 Jun;994:96-102 - PubMed
  93. Am J Physiol. 1990 Oct;259(4 Pt 2):R768-72 - PubMed
  94. Open Access Rheumatol. 2017 Jul 19;9:131-138 - PubMed
  95. Photochem Photobiol. 2000 Oct;72(4):526-32 - PubMed
  96. Annu Rev Biochem. 1984;53:665-715 - PubMed
  97. Peptides. 1985 Jul-Aug;6(4):685-7 - PubMed
  98. J Invest Dermatol. 2002 Dec;119(6):1244-53 - PubMed
  99. Int J Obes Relat Metab Disord. 2001 Dec;25 Suppl 5:S63-7 - PubMed
  100. Endocr Rev. 2010 Aug;31(4):506-43 - PubMed
  101. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):8016-20 - PubMed
  102. Neuroreport. 2004 Mar 1;15(3):493-8 - PubMed
  103. Drug News Perspect. 2000 Feb;13(1):19-27 - PubMed
  104. Gut. 2006 Oct;55(10):1415-22 - PubMed
  105. Pulm Pharmacol Ther. 2008 Dec;21(6):866-73 - PubMed
  106. Cell. 1997 Dec 12;91(6):789-98 - PubMed
  107. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3564-8 - PubMed
  108. Exp Neurol. 1999 Jun;157(2):359-65 - PubMed
  109. Am J Pathol. 2011 Jul;179(1):259-69 - PubMed
  110. Int J Biol Sci. 2015 Feb 23;11(4):423-33 - PubMed
  111. Neuroimmunomodulation. 1997 Jan-Feb;4(1):37-41 - PubMed
  112. Nature. 2015 Apr 2;520(7545):94-8 - PubMed
  113. Gen Comp Endocrinol. 1995 Aug;99(2):137-44 - PubMed
  114. Mol Endocrinol. 2011 Jan;25(1):138-56 - PubMed
  115. Biochem Pharmacol. 2001 Mar 1;61(5):613-21 - PubMed
  116. J Invest Dermatol. 2007 May;127(5):1210-6 - PubMed
  117. Ann Rheum Dis. 1949 Jun;8(2):97-104 - PubMed
  118. J Surg Res. 2006 May 15;132(2):201-7 - PubMed
  119. Endocrinology. 2007 Oct;148(10):4918-26 - PubMed
  120. Ann N Y Acad Sci. 1999 Oct 20;885:230-8 - PubMed
  121. J Leukoc Biol. 2002 Nov;72(5):946-52 - PubMed
  122. Am J Physiol Endocrinol Metab. 2003 Mar;284(3):E468-74 - PubMed
  123. Biochem Biophys Res Commun. 1994 May 16;200(3):1214-20 - PubMed
  124. J Biol Chem. 2009 Sep 25;284(39):26411-20 - PubMed
  125. Am J Physiol. 1968 Mar;214(3):538-42 - PubMed
  126. Neuroreport. 1995 Nov 13;6(16):2193-6 - PubMed
  127. Brain Res Dev Brain Res. 2003 Jun 12;143(1):83-97 - PubMed
  128. Peptides. 1991 Jul-Aug;12(4):767-71 - PubMed
  129. Neurology. 1968 Jun;18(6):Suppl:1-10 - PubMed
  130. Inflamm Bowel Dis. 2008 Mar;14(3):324-31 - PubMed
  131. Proc Natl Acad Sci U S A. 1978 Oct;75(10):5160-4 - PubMed
  132. Prostaglandins Leukot Essent Fatty Acids. 2004 Jul;71(1):1-5 - PubMed
  133. Neuropharmacology. 1984 Jan;23(1):49-53 - PubMed
  134. Brain Res Bull. 1989 Dec;23(6):573-5 - PubMed
  135. J Immunol. 1986 Oct 1;137(7):2232-6 - PubMed
  136. Int J Cancer. 1990 Dec 15;46(6):1124-30 - PubMed
  137. Ann N Y Acad Sci. 1999 Oct 20;885:254-61 - PubMed
  138. Neurology. 1970 May;20(5):1-59 - PubMed
  139. J Immunol. 1996 Apr 1;156(7):2517-21 - PubMed
  140. Peptides. 1982 Sep-Oct;3(5):775-9 - PubMed
  141. Ann Neurol. 2016 Mar;79(3):475-84 - PubMed
  142. Endocr Rev. 2006 Dec;27(7):736-49 - PubMed
  143. Front Physiol. 2018 Oct 26;9:1475 - PubMed
  144. Peptides. 1984 Jul-Aug;5(4):815-7 - PubMed
  145. Endocr Rev. 2008 Aug;29(5):581-602 - PubMed
  146. Biochem Biophys Res Commun. 1999 Dec 20;266(2):542-6 - PubMed
  147. FEBS Lett. 1992 Sep 14;309(3):417-20 - PubMed
  148. J Neurosci. 2000 May 1;20(9):3442-8 - PubMed
  149. Endocrinology. 2001 Oct;142(10):4282-7 - PubMed
  150. FASEB J. 2006 Nov;20(13):2234-41 - PubMed
  151. Biochemistry. 1994 Apr 19;33(15):4543-9 - PubMed
  152. Endocrinology. 2005 Nov;146(11):4635-46 - PubMed
  153. Pharmacol Rev. 2004 Mar;56(1):1-29 - PubMed
  154. J Biol Chem. 1993 Jul 15;268(20):15174-9 - PubMed
  155. J Neurosci. 2001 Jun 1;21(11):3849-59 - PubMed
  156. Eur J Pharmacol. 2002 Nov 1;454(1):71-9 - PubMed
  157. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):8856-60 - PubMed
  158. Endocrinology. 2003 Jan;144(1):360-70 - PubMed
  159. Peptides. 2006 Feb;27(2):421-30 - PubMed
  160. J Neurochem. 1998 Jun;70(6):2416-23 - PubMed
  161. Exp Neurol. 2015 Nov;273:161-7 - PubMed
  162. Adv Ther. 2017 Aug;34(8):1775-1790 - PubMed
  163. J Neuroimmunol. 2001 Nov 1;120(1-2):67-77 - PubMed
  164. Nature. 1994 Oct 27;371(6500):799-802 - PubMed
  165. Brain Res Mol Brain Res. 1992 Nov;16(1-2):135-42 - PubMed
  166. J Invest Dermatol. 1999 Oct;113(4):560-6 - PubMed
  167. Biochem Biophys Res Commun. 1990 Dec 14;173(2):653-9 - PubMed
  168. J Biol Chem. 1985 Nov 5;260(25):13685-9 - PubMed
  169. Peptides. 1983 Mar-Apr;4(2):199-203 - PubMed
  170. J Immunol. 1997 Apr 1;158(7):3378-84 - PubMed
  171. J Immunol. 2015 Apr 1;194(7):3381-8 - PubMed
  172. FEBS Lett. 2004 Jul 16;570(1-3):223-6 - PubMed
  173. Endocr Rev. 2000 Oct;21(5):457-87 - PubMed
  174. J Med Chem. 2004 Mar 25;47(7):1602-4 - PubMed
  175. Am J Physiol. 1999 May;276(5):R1289-94 - PubMed
  176. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):4922-6 - PubMed
  177. J Invest Dermatol. 2000 Mar;114(3):520-6 - PubMed
  178. J Invest Dermatol. 2014 Dec;134(12):2869-2872 - PubMed
  179. Science. 1983 Jul 8;221(4606):192-3 - PubMed
  180. Clin Endocrinol (Oxf). 1985 Jun;22(6):823-7 - PubMed
  181. Biochim Biophys Acta. 2013 Dec;1832(12):1939-48 - PubMed
  182. J Comp Neurol. 2003 Mar 10;457(3):213-35 - PubMed
  183. Arthritis Rheum. 2009 Oct;60(10):3017-27 - PubMed
  184. Brain Res Bull. 1987 Apr;18(4):473-7 - PubMed
  185. Mol Endocrinol. 1992 Mar;6(3):485-97 - PubMed
  186. J Biol Chem. 1993 Apr 15;268(11):8246-50 - PubMed
  187. Int J Dev Neurosci. 2011 Dec;29(8):923-35 - PubMed
  188. J Endocrinol. 2002 Mar;172(3):411-21 - PubMed
  189. J Clin Invest. 1961 Nov;40:1997-2006 - PubMed
  190. Curr Eye Res. 1992 Dec;11(12):1199-206 - PubMed
  191. Cell Mol Biol (Noisy-le-grand). 2006 May 30;52(2):53-9 - PubMed

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