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Ben Salem M, Affes H, Dhouibi R, et al. Effect of Artichoke (. Arch Physiol Biochem. 2019;1-11doi: 10.1080/13813455.2019.1670213.
Ben Salem, M., Affes, H., Dhouibi, R., Charfi, S., Turki, M., Hammami, S., Ayedi, F., Sahnoun, Z., Zeghal, K. M., & Ksouda, K. (2019). Effect of Artichoke (. Archives of physiology and biochemistry, 1-11. https://doi.org/10.1080/13813455.2019.1670213
Ben Salem, Maryem, et al. "Effect of Artichoke (." Archives of physiology and biochemistry vol. (2019): 1-11. doi: https://doi.org/10.1080/13813455.2019.1670213
Ben Salem M, Affes H, Dhouibi R, Charfi S, Turki M, Hammami S, Ayedi F, Sahnoun Z, Zeghal KM, Ksouda K. Effect of Artichoke (. Arch Physiol Biochem. 2019 Sep 28;1-11. doi: 10.1080/13813455.2019.1670213. Epub 2019 Sep 28. PMID: 31564131.
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Arch Physiol Biochem. 2019 Sep 28;1-11. doi: 10.1080/13813455.2019.1670213. Epub 2019 Sep 28.

Effect of Artichoke (.

Archives of physiology and biochemistry

Maryem Ben Salem, Hanen Affes, Raouia Dhouibi, Slim Charfi, Mouna Turki, Serria Hammami, Fatma Ayedi, Zouheir Sahnoun, Khaled Mounir Zeghal, Kamilia Ksouda

Affiliations

  1. Laboratory of Pharmacology, Faculty of Medicine, University of Sfax , Sfax , Tunisia.
  2. Laboratory of Anatomopathology, CHU Habib Bourguiba, University of Sfax , Sfax , Tunisia.
  3. Biochemistry Laboratory, CHU Habib Bourguiba, University of Sfax , Sfax , Tunisia.

PMID: 31564131 DOI: 10.1080/13813455.2019.1670213

Abstract

Obesity plays a pivotal role in the insulin resistance disease, which is related to hypertension, hyperlipidemia, type 2 diabetes mellitus, and an increased risk of cardiovascular disease. The purpose of the present study was done to evaluate the effect of artichoke leaves extract (ALE) in the high-fat diet (HFD)-induced cellular obesity and cardiac damage in Wistar rats. Body and organ weights, serum lipid profile, cardiac markers, and antioxidants enzymes were measured. Oral administration of ALE at two doses 200 and 400 mg/kg for a period of 60 days showed a significant decrease in body and organ weights, serum total cholesterol, triglycerides, LDH, ALT accompanied by decreasing in oxidative stress biomarker (MDA, and AOPP) and increasing antioxidant enzymes (SOD, CAT, and GPx) levels as compared to HFD groups. The histological findings showed a cardioprotective effect of ALE. These findings suggest that ALE exert anti-oxidant cardiac effects in HFD- induced obese rats.

Keywords: Artichoke; HFD; antioxidant; cardiac; leaves

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