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Ganguly M, Ford JB, Zhuo J, et al. Voltage-gated potassium channels are critical for infrared inhibition of action potentials: an experimental study. Neurophotonics. 2019;6(4):040501doi: 10.1117/1.NPh.6.4.040501.
Ganguly, M., Ford, J. B., Zhuo, J., McPheeters, M. T., Jenkins, M. W., Chiel, H. J., & Jansen, E. D. (2019). Voltage-gated potassium channels are critical for infrared inhibition of action potentials: an experimental study. Neurophotonics, 6(4), 040501. https://doi.org/10.1117/1.NPh.6.4.040501
Ganguly, Mohit, et al. "Voltage-gated potassium channels are critical for infrared inhibition of action potentials: an experimental study." Neurophotonics vol. 6,4 (2019): 040501. doi: https://doi.org/10.1117/1.NPh.6.4.040501
Ganguly M, Ford JB, Zhuo J, McPheeters MT, Jenkins MW, Chiel HJ, Jansen ED. Voltage-gated potassium channels are critical for infrared inhibition of action potentials: an experimental study. Neurophotonics. 2019 Oct;6(4):040501. doi: 10.1117/1.NPh.6.4.040501. Epub 2019 Oct 15. PMID: 31620544; PMCID: PMC6792434.
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Neurophotonics. 2019 Oct;6(4):040501. doi: 10.1117/1.NPh.6.4.040501. Epub 2019 Oct 15.

Voltage-gated potassium channels are critical for infrared inhibition of action potentials: an experimental study.

Neurophotonics

Mohit Ganguly, Jeremy B Ford, Junqi Zhuo, Matthew T McPheeters, Michael W Jenkins, Hillel J Chiel, E Duco Jansen

Affiliations

  1. Vanderbilt University, Department of Biomedical Engineering, Nashville, Tennessee, United States.
  2. Vanderbilt University, Biophotonics Center, Nashville, Tennessee, United States.
  3. Case Western Reserve University, Department of Biomedical Engineering, Cleveland, Ohio, United States.
  4. Case Western Reserve University, Department of Pediatrics, Cleveland, Ohio, United States.
  5. Case Western Reserve University, Department of Biology, Cleveland, Ohio, United States.
  6. Case Western Reserve University, Department of Neurosciences, Cleveland, Ohio, United States.
  7. Vanderbilt University, Department of Neurological Surgery, Nashville, Tennessee, United States.

PMID: 31620544 PMCID: PMC6792434 DOI: 10.1117/1.NPh.6.4.040501

Abstract

Thermal block of unmyelinated axons may serve as a modality for control, suggesting a means for providing therapies for pain. Computational modeling predicted that potassium channels are necessary for mediating thermal block of propagating compound action potentials (CAPs) with infrared (IR) light. Our study tests that hypothesis. Results suggest that potassium channel blockers disrupt the ability of IR to block propagating CAPs in

© The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

Keywords: infrared inhibition; potassium channels; sodium channels; tetraethylammonium chloride; tetrodotoxin

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