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Ciftciler R, Haznedaroglu IC, Aksu S, et al. The Factors Affecting Early Death in Newly Diagnosed APL Patients. Open Med (Wars). 2019;14:647-652doi: 10.1515/med-2019-0074.
Ciftciler, R., Haznedaroglu, I. C., Aksu, S., Ozcebe, O., Sayınalp, N., Malkan, U. Y., & Buyukasık, Y. (2019). The Factors Affecting Early Death in Newly Diagnosed APL Patients. Open medicine (Warsaw, Poland), 14647-652. https://doi.org/10.1515/med-2019-0074
Ciftciler, Rafiye, et al. "The Factors Affecting Early Death in Newly Diagnosed APL Patients." Open medicine (Warsaw, Poland) vol. 14 (2019): 647-652. doi: https://doi.org/10.1515/med-2019-0074
Ciftciler R, Haznedaroglu IC, Aksu S, Ozcebe O, Sayınalp N, Malkan UY, Buyukasık Y. The Factors Affecting Early Death in Newly Diagnosed APL Patients. Open Med (Wars). 2019 Sep 12;14:647-652. doi: 10.1515/med-2019-0074. eCollection 2019. PMID: 31565673; PMCID: PMC6744608.
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Open Med (Wars). 2019 Sep 12;14:647-652. doi: 10.1515/med-2019-0074. eCollection 2019.

The Factors Affecting Early Death in Newly Diagnosed APL Patients.

Open medicine (Warsaw, Poland)

Rafiye Ciftciler, Ibrahim Celalettin Haznedaroglu, Salih Aksu, Osman Ozcebe, Nilgun Sayınalp, Umit Yavuz Malkan, Yahya Buyukasık

Affiliations

  1. Hacettepe University Faculty of Medicine, Department of Hematology; Ankara, Turkey.
  2. D?skap? Education and Research Hospital, Department of Hematology, Ankara, Turkey.

PMID: 31565673 PMCID: PMC6744608 DOI: 10.1515/med-2019-0074

Abstract

BACKGROUND AND AIM: In the past, acute promyelocytic leukemia (APL) was considered as one of the most rapidly lethal form of acute myeloid leukemia (AML). The objective of this study was to assess clinical parameters affecting early death (ED) in patients with APL.

MATERIALS AND METHODS: Forty-three patients with APL who were diagnosed at Hacettepe University Hospital between the years of 2005 and 2018 were evaluated.

RESULTS: In univariate analyses, presentation with hemorrhage, DIC or infection at diagnosis, ECOG performance score, blast percentage on bone marrow, Sanz score, leukocyte, thrombocyte, fibrinogen and LDH levels were found to be statistically significantly different between patients with ER and patients without ED. In multivariate analysis, presentation with hemorrhage, DIC or infection at diagnosis, ECOG performance score, blast percentage on bone marrow, Sanz score, leukocyte, thrombocyte, fibrinogen, and LDH levels were found to be independent factors that are related with higher rate of ED in 30 days after treatment.

CONCLUSION: Induction chemotherapy should be started as soon as possible after diagnosis of APL. Improving ED rates may become the greatest challenge for the future treatment of the diseases.

© 2019 Rafiye Ciftciler et al. published by De Gruyter.

Keywords: Acute promyelocytic leukemia; All-trans retinoic acid; Disseminated intravascular coagulation

Conflict of interest statement

Conflict of interest Conflict of interests: The authors of this paper have no conflict of interests, including specific financial interests, relationships, and/or affiliations relevant to the subject

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