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Aalders M, Kok W. Comparison of Hemodynamic Factors Predicting Prognosis in Heart Failure: A Systematic Review. J Clin Med. 2019;8(10)doi: 10.3390/jcm8101757.
Aalders, M., & Kok, W. (2019). Comparison of Hemodynamic Factors Predicting Prognosis in Heart Failure: A Systematic Review. Journal of clinical medicine, 8(10), . https://doi.org/10.3390/jcm8101757
Aalders, Margot, and Kok, Wouter. "Comparison of Hemodynamic Factors Predicting Prognosis in Heart Failure: A Systematic Review." Journal of clinical medicine vol. 8,10 (2019). doi: https://doi.org/10.3390/jcm8101757
Aalders M, Kok W. Comparison of Hemodynamic Factors Predicting Prognosis in Heart Failure: A Systematic Review. J Clin Med. 2019 Oct 22;8(10). doi: 10.3390/jcm8101757. PMID: 31652650; PMCID: PMC6832156.
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J Clin Med. 2019 Oct 22;8(10). doi: 10.3390/jcm8101757.

Comparison of Hemodynamic Factors Predicting Prognosis in Heart Failure: A Systematic Review.

Journal of clinical medicine

Margot Aalders, Wouter Kok

Affiliations

  1. Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands. [email protected].
  2. Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands. [email protected].

PMID: 31652650 PMCID: PMC6832156 DOI: 10.3390/jcm8101757

Abstract

OBJECTIVES: We systematically reviewed the literature to address the question of which of the three hemodynamic factors predicts prognosis best in heart failure patients when directly compared to each other: cardiac output, preload or afterload.

METHODS: Prognostic studies in heart failure (HF) were searched that included at least two of the three hemodynamic variables: (1) cardiac output or cardiac index (CI), (2) preload represented by pulmonary capillary wedge pressure (PCWP) and (3) afterload simplified to systolic blood pressure (SBP). Critical appraisal was done according to the QUIPS format for prognostic studies. The main endpoint was all-cause mortality, which could be combined with other endpoints. We report the number of studies in which CI, PCWP and SBP remained significant prognostic predictors in multivariate analysis. We also assessed whether hemodynamic predictors of prognosis varied in four different HF-populations.

RESULTS: Included were 18 studies containing a multivariate analysis. PCWP was an independent predictor of prognosis in 10 of 18 studies, SBP in 3 of 14 studies and CI in none of 18 studies. Results were not specific for any of the HF-populations.

CONCLUSIONS: A higher PCWP and lower SBP are independent predictors of poor prognosis in HF. In spite of the frequently used concept behind HF, this review demonstrates that CI is not an independent predictor of prognosis in HF.

Keywords: afterload; cardiac output; heart failure; preload; prognosis

Conflict of interest statement

The authors declare no conflict of interest.

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