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Tatarchenko IP, Pozdnyakova NV, Mordovina AG, et al. [Significanvce of dysfunction of vascular endothelium for the evaluation of episodes of myocardial ischemia in type 2 diabetes mellitus]. Probl Endokrinol (Mosk). 2009;55(6):7-11doi: 10.14341/probl20095567-11.
Tatarchenko, I. P., Pozdnyakova, N. V., Mordovina, A. G., Morozova, O. I., & Kolomiets, E. V. (2009). [Significanvce of dysfunction of vascular endothelium for the evaluation of episodes of myocardial ischemia in type 2 diabetes mellitus]. Problemy endokrinologii, 55(6), 7-11. https://doi.org/10.14341/probl20095567-11
Tatarchenko, I P, et al. "[Significanvce of dysfunction of vascular endothelium for the evaluation of episodes of myocardial ischemia in type 2 diabetes mellitus]." Problemy endokrinologii vol. 55,6 (2009): 7-11. doi: https://doi.org/10.14341/probl20095567-11
Tatarchenko IP, Pozdnyakova NV, Mordovina AG, Morozova OI, Kolomiets EV. [Significanvce of dysfunction of vascular endothelium for the evaluation of episodes of myocardial ischemia in type 2 diabetes mellitus]. Probl Endokrinol (Mosk). 2009 Dec 15;55(6):7-11. doi: 10.14341/probl20095567-11. Russian. PMID: 31569883.
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Probl Endokrinol (Mosk). 2009 Dec 15;55(6):7-11. doi: 10.14341/probl20095567-11.

[Significanvce of dysfunction of vascular endothelium for the evaluation of episodes of myocardial ischemia in type 2 diabetes mellitus].

Problemy endokrinologii

[Article in Russian]
I P Tatarchenko, N V Pozdnyakova, A G Mordovina, O I Morozova, E V Kolomiets

Affiliations

  1. Penza Institute of Advanced Medical Training.
  2. Medical Sanitary Unit No 59, Federal Medico-Biological Agency.

PMID: 31569883 DOI: 10.14341/probl20095567-11

Abstract

The objective of this study was to evaluate the vasculomotor function of endothelium in patients with type 2 diabetes mellitus and assess the role of its functional state in the development of ischemic episodes. A total of 93 patients (52 men and 41 women) of the mean age of 58.3+-4.8 years were involved in the study. Group 1 comprised 47 patients with coronary heart disease (CHD) and type 2 diabetes, group 2 included 46 patients with CHD in the absence of disturbances of carbohydrate metabolism. Patients of the two groups were matched for age, gender, and major risk factors. Their comprehensive examination included 24 hour ECG monitoring, veloergometry, echocardiography, and reactive hyperemia test (ultrasound evaluation of endothelium-dependent dilation of the brachial artery). The patients of group 2 showed longer total duration of episodes of myocardial ischemia, the elevated number of painless (PMI) episodes, and greater maximum depression of ST-segment compared with CHD patients having no disturbances of carbohydrate metabolism. Correlation analysis demonstrated significant negative relationship between endothelial dysfunction, the number and duration of PMI episodes, and delay of pain syndrome with respect to ischemic depression of ST-segment in patients of group 1.

Keywords: coronary heart disease; diabetes mellitus; endothelial dysfunction; painless myocardial ischemia

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