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Abbas E. Comorbid CAD and ventricular hypertrophy compromise the perfusion of myocardial tissue at subcritical stenosis of epicardial coronaries. Egypt Heart J. 2019;71(1):3doi: 10.1186/s43044-019-0003-5.
Abbas, E. (2019). Comorbid CAD and ventricular hypertrophy compromise the perfusion of myocardial tissue at subcritical stenosis of epicardial coronaries. The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology, 71(1), 3. https://doi.org/10.1186/s43044-019-0003-5
Abbas, Eslam. "Comorbid CAD and ventricular hypertrophy compromise the perfusion of myocardial tissue at subcritical stenosis of epicardial coronaries." The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology vol. 71,1 (2019): 3. doi: https://doi.org/10.1186/s43044-019-0003-5
Abbas E. Comorbid CAD and ventricular hypertrophy compromise the perfusion of myocardial tissue at subcritical stenosis of epicardial coronaries. Egypt Heart J. 2019 Aug 05;71(1):3. doi: 10.1186/s43044-019-0003-5. PMID: 31659531; PMCID: PMC6821408.
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Egypt Heart J. 2019 Aug 05;71(1):3. doi: 10.1186/s43044-019-0003-5.

Comorbid CAD and ventricular hypertrophy compromise the perfusion of myocardial tissue at subcritical stenosis of epicardial coronaries.

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology

Eslam Abbas

Affiliations

  1. Kobri El Koba Medical Complex, El Khalifa El Maamoun St. Intersection of El Fangary St, Heliopolis, Cairo, 11766, Egypt. [email protected].

PMID: 31659531 PMCID: PMC6821408 DOI: 10.1186/s43044-019-0003-5

Abstract

BACKGROUND: Most studies of CAD revascularization have been based on and reported according to angiographic criteria which do not consider the relation between the resulting effective flow distal to the stenosis and the demand of a hypertrophied myocardial tissue.

RESULTS: A mathematical model of the myocardial perfusion in comorbid CAD and ventricular hypertrophy, using Poiseuille's law, indicates that the affected patients are more sensitive to CAD-related hemodynamic changes. They are more prone to develop ischemic complications, mainly non-ST-elevation myocardial infarction (NSTEMI), and arrhythmias than their peers with isolated CAD regarding the same degree of coronary stenosis.

CONCLUSION: Patients with comorbid CAD and ventricular hypertrophy suffer from myocardial hypoperfusion at subcritical epicardial stenosis. Accordingly, the comorbidity of both diseases should be considered upon designing of the treatment regimen.

Keywords: Arrhythmia; CAD; MI; Structural resistance; Ventricular hypertrophy

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