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He QE, Xia M, Ying GH, et al. Severe mental disorders following anti-retroviral treatment in a patient on peritoneal dialysis: A case report and literature review. World J Clin Cases. 2019;7(20):3329-3334doi: 10.12998/wjcc.v7.i20.3329.
He, Q. E., Xia, M., Ying, G. H., He, X. L., Chen, J. H., & Yang, Y. (2019). Severe mental disorders following anti-retroviral treatment in a patient on peritoneal dialysis: A case report and literature review. World journal of clinical cases, 7(20), 3329-3334. https://doi.org/10.12998/wjcc.v7.i20.3329
He, Qi-En, et al. "Severe mental disorders following anti-retroviral treatment in a patient on peritoneal dialysis: A case report and literature review." World journal of clinical cases vol. 7,20 (2019): 3329-3334. doi: https://doi.org/10.12998/wjcc.v7.i20.3329
He QE, Xia M, Ying GH, He XL, Chen JH, Yang Y. Severe mental disorders following anti-retroviral treatment in a patient on peritoneal dialysis: A case report and literature review. World J Clin Cases. 2019 Oct 26;7(20):3329-3334. doi: 10.12998/wjcc.v7.i20.3329. PMID: 31667187; PMCID: PMC6819294.
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World J Clin Cases. 2019 Oct 26;7(20):3329-3334. doi: 10.12998/wjcc.v7.i20.3329.

Severe mental disorders following anti-retroviral treatment in a patient on peritoneal dialysis: A case report and literature review.

World journal of clinical cases

Qi-En He, Min Xia, Guang-Hui Ying, Xue-Lin He, Jiang-Hua Chen, Yi Yang

Affiliations

  1. Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Kidney Disease Prevention and Control Technology, Zhejiang Province, the Third Grade Laboratory Under the National State, Administration of Traditional Chinese Medicine, Hangzhou 310000, Zhejiang Province, China.
  2. Department of Nephrology, Beilun People's Hospital, Ningbo 315000, Zhejiang Province, China.
  3. Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Kidney Disease Prevention and Control Technology, Zhejiang Province, the Third Grade Laboratory Under the National State, Administration of Traditional Chinese Medicine, Hangzhou 310000, Zhejiang Province, China. [email protected].

PMID: 31667187 PMCID: PMC6819294 DOI: 10.12998/wjcc.v7.i20.3329

Abstract

BACKGROUND: Antiviral drugs are widely used in populations with viral infection caused by immunologic inadequacy. Because these drugs are mainly metabolized by the kidneys, patients with renal failure undergoing renal replacement therapy are prone to drug adverse effects and poisoning. Severe neurotoxicity caused by antiviral drugs is a rare but life-threatening complication.

CASE SUMMARY: This study reported one male patient on peritoneal dialysis who suffered from severe mental disorders after receiving an overdose of acyclovir and valacyclovir for the treatment of herpes zoster. The literature review suggested that hemodialysis is better than peritoneal dialysis to clear acyclovir from the circulation. The patient died after his consciousness deteriorated despite peritoneal dialysis and continuous blood purification.

CONCLUSION: This case emphasizes cautiousness when using anti-retroviral drugs in patients with uremia. Hemodialysis is optimal method to remove the drugs.

©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

Keywords: Acyclovir; Case report; Chronic renal failure; Herpes zoster; Neurotoxicity; Peritoneal dialysis; Valacyclovir

Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no conflicts of interest.

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