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Jung W, Jang KI, Lee SH. Heart and Brain Interaction of Psychiatric Illness: A Review Focused on Heart Rate Variability, Cognitive Function, and Quantitative Electroencephalography. Clin Psychopharmacol Neurosci. 2019;17(4):459-474doi: 10.9758/cpn.2019.17.4.459.
Jung, W., Jang, K. I., & Lee, S. H. (2019). Heart and Brain Interaction of Psychiatric Illness: A Review Focused on Heart Rate Variability, Cognitive Function, and Quantitative Electroencephalography. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 17(4), 459-474. https://doi.org/10.9758/cpn.2019.17.4.459
Jung, Wookyoung, et al. "Heart and Brain Interaction of Psychiatric Illness: A Review Focused on Heart Rate Variability, Cognitive Function, and Quantitative Electroencephalography." Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology vol. 17,4 (2019): 459-474. doi: https://doi.org/10.9758/cpn.2019.17.4.459
Jung W, Jang KI, Lee SH. Heart and Brain Interaction of Psychiatric Illness: A Review Focused on Heart Rate Variability, Cognitive Function, and Quantitative Electroencephalography. Clin Psychopharmacol Neurosci. 2019 Nov 20;17(4):459-474. doi: 10.9758/cpn.2019.17.4.459. PMID: 31671483; PMCID: PMC6852682.
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Clin Psychopharmacol Neurosci. 2019 Nov 20;17(4):459-474. doi: 10.9758/cpn.2019.17.4.459.

Heart and Brain Interaction of Psychiatric Illness: A Review Focused on Heart Rate Variability, Cognitive Function, and Quantitative Electroencephalography.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

Wookyoung Jung, Kuk-In Jang, Seung-Hwan Lee

Affiliations

  1. Department of Psychology, Keimyung University, Daegu, Korea.
  2. 2Department of Biomedicine and Health Sciences, College of Medicine, The Catholic University of Korea, Korea.
  3. Institute of Biomedical Industry, The Catholic University of Korea, Seoul, Korea.
  4. Department of Psychiatry,Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
  5. Clinical Emotion and Cognition Research Laboratory, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.

PMID: 31671483 PMCID: PMC6852682 DOI: 10.9758/cpn.2019.17.4.459

Abstract

Heart rate variability (HRV) reflects beat-to-beat variability in the heart rate due to the dynamic interplay of the sympathetic and parasympathetic nervous systems. HRV is considered an index of the functional status of the autonomic nervous system. A decrease in HRV is thus observed in individuals with autonomic dysfunction. Abnormal HRV has been reported in a range of mental disorders. In this review, we give an overview of HRV in patients with major depressive disorder (MDD), schizophrenia, and posttraumatic stress disorder (PTSD), one of whose core symptoms is cognitive dysfunction. The association between HRV and cognitive function is highlighted in this review. This review consists of three main sections. In the first section, we examine how HRV in patients with MDD, schizophrenia, and PTSD is characterized, and how it is different when compared to that in healthy controls. In the second section, beyond the heart itself, we discuss the intimate connection between the heart and the brain, focusing on how HRV interacts with quantitative electroencephalography (qEEG) in the context of physiological changes in the sleep cycle. Lastly, we finish the review with the examination of the association between HRV and cognitive function. The overall findings indicate that the reduction in HRV is one of main manifestations in MDD, schizophrenia, and PTSD, and also more generally HRV is closely linked to the change in qEEG and also to individual differences in cognitive performance.

Keywords: Cognition.; Electroencephalography; Heart rate variability; Major depressive disorder; Posttraumatic stress disorder; Schizophrenia

References

  1. Biol Psychiatry. 1990 Apr 1;27(7):757-80 - PubMed
  2. Fiziol Cheloveka. 2000 Jul-Aug;26(4):48-54 - PubMed
  3. Am J Cardiol. 1990 Nov 1;66(15):1049-54 - PubMed
  4. Circulation. 2003 Feb 4;107(4):565-70 - PubMed
  5. Int J Psychophysiol. 2009 Sep;73(3):257-64 - PubMed
  6. Psychiatry Res. 1991 Apr;37(1):35-46 - PubMed
  7. Br Heart J. 1994 Jan;71(1):1-2 - PubMed
  8. Psychophysiology. 2015 Apr;52(4):572-84 - PubMed
  9. Biol Psychiatry. 2010 Nov 1;68(9):861-8 - PubMed
  10. Psychophysiology. 2013 May;50(5):477-87 - PubMed
  11. Arch Gen Psychiatry. 2001 Mar;58(3):221-7 - PubMed
  12. Circulation. 1991 Aug;84(2):482-92 - PubMed
  13. Curr Alzheimer Res. 2018;15(1):80-88 - PubMed
  14. Pharmacopsychiatry. 1994 May;27(3):124-8 - PubMed
  15. Clin Psychopharmacol Neurosci. 2013 Dec;11(3):137-43 - PubMed
  16. Int J Psychophysiol. 2015 Oct;98(1):76-86 - PubMed
  17. Psychiatry Res. 2002 Dec 15;113(1-2):139-49 - PubMed
  18. J Electrocardiol. 1988;21 Suppl:S46-55 - PubMed
  19. Clin Psychopharmacol Neurosci. 2017 May 31;15(2):138-145 - PubMed
  20. Biol Psychol. 2007 Feb;74(2):200-11 - PubMed
  21. Brain Res Cogn Brain Res. 2001 Dec;12(3):467-73 - PubMed
  22. J Affect Disord. 1998 Mar;48(2-3):115-24 - PubMed
  23. Biol Psychol. 2009 Oct;82(2):164-168 - PubMed
  24. Tohoku J Exp Med. 2005 Jul;206(3):213-8 - PubMed
  25. Am J Cardiol. 1996 Sep 15;78(6):613-7 - PubMed
  26. Brain Res Bull. 2010 Mar 16;81(4-5):445-52 - PubMed
  27. Int Marit Health. 2012;63(4):181-7 - PubMed
  28. Psychiatry Res. 2013 Dec 30;210(3):710-5 - PubMed
  29. Neuroepidemiology. 2008;31(2):115-21 - PubMed
  30. Circulation. 1997 Nov 4;96(9):3224-32 - PubMed
  31. J Exp Psychol. 1969 Sep;81(3):497-503 - PubMed
  32. Biol Psychiatry. 1986 Oct;21(12):1175-88 - PubMed
  33. Biol Psychol. 2011 Dec;88(2-3):215-22 - PubMed
  34. Psychosom Med. 2012 Feb-Mar;74(2):153-9 - PubMed
  35. J Neurol Neurosurg Psychiatry. 1995 Sep;59(3):299-302 - PubMed
  36. J Child Psychol Psychiatry. 2018 Mar;59(3):223-231 - PubMed
  37. Nord J Psychiatry. 2003;57(5):351-5 - PubMed
  38. Nat Neurosci. 2004 Feb;7(2):189-95 - PubMed
  39. Isr Med Assoc J. 2000 Apr;2(4):296-301 - PubMed
  40. J Psychiatr Res. 2013 May;47(5):628-35 - PubMed
  41. Eur Heart J. 1996 Mar;17(3):354-81 - PubMed
  42. Biol Psychiatry. 2004 Feb 1;55(3):284-90 - PubMed
  43. Am J Epidemiol. 1997 May 15;145(10):899-908 - PubMed
  44. Psychosom Med. 2001 Jul-Aug;63(4):585-94 - PubMed
  45. Psychiatry Investig. 2013 Jun;10(2):121-30 - PubMed
  46. Arch Neurol. 1997 Jun;54(6):741-4 - PubMed
  47. Psychol Sci. 2007 Mar;18(3):275-81 - PubMed
  48. J Clin Psychiatry. 2000;61 Suppl 5:60-6 - PubMed
  49. Br J Psychiatry. 2001 Aug;179:167-71 - PubMed
  50. Biol Psychol. 2009 May;81(2):110-7 - PubMed
  51. Circulation. 1994 Jul;90(1):121-6 - PubMed
  52. Arch Gen Psychiatry. 2008 Dec;65(12):1358-67 - PubMed
  53. Am J Ment Defic. 1977 Sep;82(2):162-9 - PubMed
  54. Psychiatry Clin Neurosci. 2001 Jun;55(3):285-6 - PubMed
  55. Biopsychosoc Med. 2008 Jun 30;2:12 - PubMed
  56. Am J Obstet Gynecol. 1963 Nov 15;87:814-26 - PubMed
  57. Psychophysiology. 1997 Nov;34(6):623-48 - PubMed
  58. Circulation. 1998 Oct 13;98(15):1510-6 - PubMed
  59. J Exp Psychol. 1972 Dec;96(2):371-9 - PubMed
  60. Clin Psychopharmacol Neurosci. 2018 Nov 30;16(4):422-433 - PubMed
  61. Ann N Y Acad Sci. 2008;1129:119-29 - PubMed
  62. PLoS One. 2013;8(2):e56935 - PubMed
  63. Neuroimage. 2008 Aug 1;42(1):158-68 - PubMed
  64. Ann Neurol. 2001 May;49(5):575-84 - PubMed
  65. Can J Psychiatry. 1998 Mar;43(2):183-6 - PubMed
  66. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13473-80 - PubMed
  67. J Anxiety Disord. 2003;17(1):75-87 - PubMed
  68. Science. 2003 Jun 13;300(5626):1755-8 - PubMed
  69. Physiol Behav. 2015 Feb;139:430-6 - PubMed
  70. Psychophysiology. 2004 Jul;41(4):521-30 - PubMed
  71. Auton Neurosci. 2003 Jan 31;103(1-2):114-20 - PubMed
  72. Trends Cogn Sci. 2011 Feb;15(2):85-93 - PubMed
  73. Neurosci Biobehav Rev. 2009 Feb;33(2):81-8 - PubMed
  74. J Psychiatry Neurosci. 2016 Mar;41(2):89-104 - PubMed
  75. J Clin Neurophysiol. 2017 May;34(3):230-235 - PubMed
  76. Appl Psychophysiol Biofeedback. 2013 Mar;38(1):57-69 - PubMed
  77. Am J Cardiol. 1987 Dec 1;60(16):1273-5 - PubMed
  78. Biol Psychiatry. 1998 Nov 15;44(10):1054-9 - PubMed
  79. Biol Psychiatry. 1982 Mar;17(3):305-16 - PubMed
  80. Biol Psychiatry. 2010 Jun 1;67(11):1067-74 - PubMed
  81. Arch Gen Psychiatry. 1982 Dec;39(12):1423-35 - PubMed
  82. Am J Physiol. 1999 Jan;276(1):H215-23 - PubMed
  83. Psychopharmacology (Berl). 1998 Feb;135(4):338-41 - PubMed
  84. Schizophr Res. 2008 Feb;99(1-3):225-37 - PubMed
  85. J Psychiatr Res. 2005 Sep;39(5):519-27 - PubMed
  86. Psychosom Med. 2007 Dec;69(9):935-43 - PubMed
  87. Clin Psychopharmacol Neurosci. 2018 Feb 28;16(1):18-31 - PubMed
  88. Am J Pharm Educ. 2007 Aug 15;71(4):78 - PubMed
  89. Psychophysiology. 2004 Jan;41(1):75-83 - PubMed
  90. Psychophysiology. 2002 Nov;39(6):861-4 - PubMed
  91. Ann Behav Med. 2009 Apr;37(2):141-53 - PubMed
  92. Ann N Y Acad Sci. 2006 Nov;1088:361-72 - PubMed
  93. Circulation. 1995 Apr 1;91(7):1918-22 - PubMed
  94. Psychol Med. 2015 Feb;45(3):623-36 - PubMed
  95. Ann N Y Acad Sci. 1990;601:209-21 - PubMed
  96. PLoS One. 2017 Aug 3;12(8):e0181833 - PubMed
  97. Br J Psychiatry. 2016 Jan;208(1):9-16 - PubMed
  98. J Psychiatry Neurosci. 2005 Nov;30(6):393-5 - PubMed
  99. Psychoneuroendocrinology. 2005 Nov;30(10):1050-8 - PubMed
  100. Int J Psychophysiol. 2003 Jun;48(3):263-74 - PubMed
  101. Biol Psychol. 2008 Feb;77(2):174-82 - PubMed
  102. Neuroimage. 1999 Aug;10(2):193-9 - PubMed
  103. J Clin Psychiatry. 1990 Jul;51 Suppl:4-9; discussion 10-1 - PubMed
  104. Biol Psychol. 2007 Feb;74(2):185-99 - PubMed
  105. Europace. 2013 May;15(5):742-9 - PubMed
  106. Clin Neurophysiol. 2007 Dec;118(12):2752-64 - PubMed
  107. Swiss Med Wkly. 2004 Sep 4;134(35-36):514-22 - PubMed
  108. Neuroimage. 2003 Aug;19(4):1463-76 - PubMed
  109. Psychol Bull. 2007 Sep;133(5):725-46 - PubMed
  110. Neuropsychobiology. 2005;51(1):10-5 - PubMed
  111. Nat Neurosci. 2004 Feb;7(2):102-3 - PubMed
  112. Clin Psychol Rev. 2016 Jun;46:136-50 - PubMed
  113. Psychosom Med. 2014 Oct;76(8):629-37 - PubMed
  114. Am J Cardiol. 1994 Aug 15;74(4):340-5 - PubMed
  115. Electroencephalogr Clin Neurophysiol. 1997 May;102(5):390-6 - PubMed
  116. Neuroimage Clin. 2018 Jun 12;19:1000-1007 - PubMed
  117. Depression. 1996;4(2):57-62 - PubMed
  118. Epidemiology. 1993 Jul;4(4):285-94 - PubMed
  119. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Aug 31;33(6):991-5 - PubMed
  120. Appl Psychophysiol Biofeedback. 2011 Sep;36(3):209-15 - PubMed
  121. Br J Psychiatry. 1984 Jun;144:581-92 - PubMed
  122. J Psychosom Res. 2000 Apr-May;48(4-5):493-500 - PubMed
  123. J Clin Psychopharmacol. 2001 Apr;21(2):238-9 - PubMed
  124. Electroencephalogr Clin Neurophysiol. 1960 May;12:317-26 - PubMed
  125. CNS Spectr. 2002 Jan;7(1):53-7 - PubMed
  126. Psychophysiology. 2003 Sep;40(5):716-26 - PubMed
  127. Scand J Psychol. 2002 Apr;43(2):123-30 - PubMed
  128. Acta Neuropsychiatr. 2011 Aug;23(4):161-6 - PubMed
  129. Dev Psychobiol. 2010 Mar;52(2):197-204 - PubMed
  130. Biol Psychiatry. 1997 Mar 1;41(5):627-9 - PubMed
  131. Am Heart J. 1999 Sep;138(3 Pt 1):567-76 - PubMed
  132. J Psychosom Res. 2006 Jan;60(1):83-90 - PubMed
  133. Am J Psychiatry. 1978 Jan;135(1):69-74 - PubMed
  134. Pain Med. 2009 Oct;10(7):1237-45 - PubMed
  135. Physiol Behav. 1997 Nov;62(5):1037-43 - PubMed
  136. Eur J Appl Physiol. 2004 Dec;93(3):263-72 - PubMed
  137. Circulation. 1996 Dec 15;94(12):3123-9 - PubMed
  138. Brain. 1999 Jul;122 ( Pt 7):1367-81 - PubMed
  139. Science. 2002 Mar 22;295(5563):2279-82 - PubMed
  140. Depress Anxiety. 2002;16(3):93-9 - PubMed
  141. Biol Psychiatry. 2011 Jan 1;69(1):80-9 - PubMed
  142. Comput Methods Programs Biomed. 2004 Oct;76(1):73-81 - PubMed
  143. Am J Epidemiol. 1999 Dec 15;150(12):1282-8 - PubMed
  144. Front Psychol. 2014 Sep 30;5:1040 - PubMed
  145. Glob Adv Health Med. 2015 Jan;4(1):46-61 - PubMed
  146. Circ Res. 1986 Aug;59(2):178-93 - PubMed
  147. Biol Psychiatry. 2001 Apr 1;49(7):637-43 - PubMed
  148. Anxiety Stress Coping. 2009 Jan;22(1):77-89 - PubMed
  149. Psychophysiology. 2018 Jan;55(1): - PubMed
  150. Psychosom Med. 2012 Jun;74(5):495-500 - PubMed
  151. Int J Psychophysiol. 2001 Mar;40(2):167-72 - PubMed
  152. J Affect Disord. 2000 Dec;61(3):201-16 - PubMed
  153. Front Psychiatry. 2018 Jan 22;8:314 - PubMed
  154. Biol Psychol. 2007 Feb;74(2):224-42 - PubMed
  155. J Affect Disord. 1996 Sep 9;40(1-2):61-71 - PubMed
  156. J Psychopharmacol. 2009 Aug;23(6):697-707 - PubMed
  157. Neuroimage. 2009 Jan 1;44(1):213-22 - PubMed
  158. Psychiatry Res. 2000 Sep 25;96(1):1-13 - PubMed
  159. Psychophysiology. 2015 Feb;52(2):214-224 - PubMed

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