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Salg GA, Giese NA, Schenk M, et al. The emerging field of pancreatic tissue engineering: A systematic review and evidence map of scaffold materials and scaffolding techniques for insulin-secreting cells. J Tissue Eng. 2019;10:2041731419884708doi: 10.1177/2041731419884708.
Salg, G. A., Giese, N. A., Schenk, M., Hüttner, F. J., Felix, K., Probst, P., Diener, M. K., Hackert, T., & Kenngott, H. G. (2019). The emerging field of pancreatic tissue engineering: A systematic review and evidence map of scaffold materials and scaffolding techniques for insulin-secreting cells. Journal of tissue engineering, 102041731419884708. https://doi.org/10.1177/2041731419884708
Salg, Gabriel Alexander, et al. "The emerging field of pancreatic tissue engineering: A systematic review and evidence map of scaffold materials and scaffolding techniques for insulin-secreting cells." Journal of tissue engineering vol. 10 (2019): 2041731419884708. doi: https://doi.org/10.1177/2041731419884708
Salg GA, Giese NA, Schenk M, Hüttner FJ, Felix K, Probst P, Diener MK, Hackert T, Kenngott HG. The emerging field of pancreatic tissue engineering: A systematic review and evidence map of scaffold materials and scaffolding techniques for insulin-secreting cells. J Tissue Eng. 2019 Oct 30;10:2041731419884708. doi: 10.1177/2041731419884708. eCollection 2019. PMID: 31700597; PMCID: PMC6823987.
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J Tissue Eng. 2019 Oct 30;10:2041731419884708. doi: 10.1177/2041731419884708. eCollection 2019.

The emerging field of pancreatic tissue engineering: A systematic review and evidence map of scaffold materials and scaffolding techniques for insulin-secreting cells.

Journal of tissue engineering

Gabriel Alexander Salg, Nathalia A Giese, Miriam Schenk, Felix J Hüttner, Klaus Felix, Pascal Probst, Markus K Diener, Thilo Hackert, Hannes Götz Kenngott

Affiliations

  1. Department of General, Abdominal and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.

PMID: 31700597 PMCID: PMC6823987 DOI: 10.1177/2041731419884708

Abstract

A bioartificial endocrine pancreas is proposed as a future alternative to current treatment options. Patients with insulin-secretion deficiency might benefit. This is the first systematic review that provides an overview of scaffold materials and techniques for insulin-secreting cells or cells to be differentiated into insulin-secreting cells. An electronic literature survey was conducted in PubMed/MEDLINE and Web of Science, limited to the past 10 years. A total of 197 articles investigating 60 different materials met the inclusion criteria. The extracted data on materials, cell types, study design, and transplantation sites were plotted into two evidence gap maps. Integral parts of the tissue engineering network such as fabrication technique, extracellular matrix, vascularization, immunoprotection, suitable transplantation sites, and the use of stem cells are highlighted. This systematic review provides an evidence-based structure for future studies. Accumulating evidence shows that scaffold-based tissue engineering can enhance the viability and function or differentiation of insulin-secreting cells both in vitro and in vivo.

© The Author(s) 2019.

Keywords: Tissue engineering; artificial organ; endocrine pancreas; evidence map; insulin-producing cell

Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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