Display options
Cite
Kong JY, Hilger RT, Jin C, et al. Integration of a Multichannel Pulsed-Valve Inlet System to a Linear Quadrupole Ion Trap Mass Spectrometer for the Rapid Consecutive Introduction of Nine Reagents for Diagnostic Ion/Molecule Reactions. Anal Chem. 2019;91(24):15652-15660doi: 10.1021/acs.analchem.9b03768.
Kong, J. Y., Hilger, R. T., Jin, C., Yerabolu, R., Zimmerman, J. R., Replogle, R. W., Jarrell, T. M., Easterling, L., Kumar, R., & Kenttämaa, H. I. (2019). Integration of a Multichannel Pulsed-Valve Inlet System to a Linear Quadrupole Ion Trap Mass Spectrometer for the Rapid Consecutive Introduction of Nine Reagents for Diagnostic Ion/Molecule Reactions. Analytical chemistry, 91(24), 15652-15660. https://doi.org/10.1021/acs.analchem.9b03768
Kong, John Y, et al. "Integration of a Multichannel Pulsed-Valve Inlet System to a Linear Quadrupole Ion Trap Mass Spectrometer for the Rapid Consecutive Introduction of Nine Reagents for Diagnostic Ion/Molecule Reactions." Analytical chemistry vol. 91,24 (2019): 15652-15660. doi: https://doi.org/10.1021/acs.analchem.9b03768
Kong JY, Hilger RT, Jin C, Yerabolu R, Zimmerman JR, Replogle RW, Jarrell TM, Easterling L, Kumar R, Kenttämaa HI. Integration of a Multichannel Pulsed-Valve Inlet System to a Linear Quadrupole Ion Trap Mass Spectrometer for the Rapid Consecutive Introduction of Nine Reagents for Diagnostic Ion/Molecule Reactions. Anal Chem. 2019 Dec 17;91(24):15652-15660. doi: 10.1021/acs.analchem.9b03768. Epub 2019 Nov 21. PMID: 31702133.
Copy Download .nbib Format: NLM
Share it on

Anal Chem. 2019 Dec 17;91(24):15652-15660. doi: 10.1021/acs.analchem.9b03768. Epub 2019 Nov 21.

Integration of a Multichannel Pulsed-Valve Inlet System to a Linear Quadrupole Ion Trap Mass Spectrometer for the Rapid Consecutive Introduction of Nine Reagents for Diagnostic Ion/Molecule Reactions.

Analytical chemistry

John Y Kong, Ryan T Hilger, Chunfen Jin, Ravikiran Yerabolu, James R Zimmerman, Randall W Replogle, Tiffany M Jarrell, Leah Easterling, Rashmi Kumar, Hilkka I Kenttämaa

Affiliations

  1. Department of Chemistry , Purdue University , West Lafayette , Indiana 47907 , United States.

PMID: 31702133 DOI: 10.1021/acs.analchem.9b03768

Abstract

Gas-phase ion/molecule reactions have been used extensively for the structural elucidation of organic compounds in tandem mass spectrometry. Reagents for ion/molecule reactions can be introduced into a mass spectrometer via a continuous flow apparatus or through a pulsed inlet system. However, most of these approaches enable the use of only a single reagent at a time. In this work, a multichannel pulsed-valve inlet system was developed for the rapid consecutive introduction of up to nine different reagents or reagent systems into a linear quadrupole ion trap mass spectrometer for diagnostic gas-phase ion/molecule reactions. Automated triggering of the pulsed valves enabled these experiments to be performed on the high-performance liquid chromatography (HPLC) time scale. This enables high-throughput screening of several functionalities in analytes as they elute from an HPLC column.

Publication Types