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Zhang JY, Jiang YT, Liu YS, et al. The association between glycemic index, glycemic load, and metabolic syndrome: a systematic review and dose-response meta-analysis of observational studies. Eur J Nutr. 2019;59(2):451-463doi: 10.1007/s00394-019-02124-z.
Zhang, J. Y., Jiang, Y. T., Liu, Y. S., Chang, Q., Zhao, Y. H., & Wu, Q. J. (2020). The association between glycemic index, glycemic load, and metabolic syndrome: a systematic review and dose-response meta-analysis of observational studies. European journal of nutrition, 59(2), 451-463. https://doi.org/10.1007/s00394-019-02124-z
Zhang, Jia-Yu, et al. "The association between glycemic index, glycemic load, and metabolic syndrome: a systematic review and dose-response meta-analysis of observational studies." European journal of nutrition vol. 59,2 (2020): 451-463. doi: https://doi.org/10.1007/s00394-019-02124-z
Zhang JY, Jiang YT, Liu YS, Chang Q, Zhao YH, Wu QJ. The association between glycemic index, glycemic load, and metabolic syndrome: a systematic review and dose-response meta-analysis of observational studies. Eur J Nutr. 2020 Mar;59(2):451-463. doi: 10.1007/s00394-019-02124-z. Epub 2019 Nov 03. PMID: 31680212.
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Eur J Nutr. 2020 Mar;59(2):451-463. doi: 10.1007/s00394-019-02124-z. Epub 2019 Nov 03.

The association between glycemic index, glycemic load, and metabolic syndrome: a systematic review and dose-response meta-analysis of observational studies.

European journal of nutrition

Jia-Yu Zhang, Yu-Ting Jiang, Ya-Shu Liu, Qing Chang, Yu-Hong Zhao, Qi-Jun Wu

Affiliations

  1. Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Shenyang, 110004, Liaoning, People's Republic of China.
  2. Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China.
  3. Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Shenyang, 110004, Liaoning, People's Republic of China. [email protected].
  4. Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China. [email protected].

PMID: 31680212 DOI: 10.1007/s00394-019-02124-z

Abstract

PURPOSE: The association of glycemic index (GI) and glycemic load (GL) with metabolic syndrome (MetS) is controversial. Therefore, we conducted this first systematic review and dose-response meta-analysis of observational studies to quantify these associations.

METHODS: We searched PubMed, EMBASE, Web of Science, and the Cochrane Library for relevant studies up to 1 April 2019. Summary odds ratios (OR) and 95% confidence intervals (CI) were calculated by a random-effects model. This study was registered with PROSPERO (CRD42019131788).

RESULTS: We included eight high-quality (n = 5) or medium-quality (n = 3) cross-sectional studies in the final meta-analysis, comprising 6058 MetS events and 28,998 participants. The summary ORs of MetS for the highest versus lowest categories were 1.23 (95% CI 1.10-1.38, I

CONCLUSIONS: Dietary GI was positively associated with the prevalence of MetS. However, no significant association was found between dietary GL and the prevalence of MetS. Further studies with prospective design are needed to establish potential causal relationship between dietary GI and the MetS.

Keywords: Glycemic index; Glycemic load; Meta-analysis; Metabolic syndrome

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