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Harvey KL, Jarocki VM, Charles IG, et al. The Diverse Functional Roles of Elongation Factor Tu (EF-Tu) in Microbial Pathogenesis. Front Microbiol. 2019;10:2351doi: 10.3389/fmicb.2019.02351.
Harvey, K. L., Jarocki, V. M., Charles, I. G., & Djordjevic, S. P. (2019). The Diverse Functional Roles of Elongation Factor Tu (EF-Tu) in Microbial Pathogenesis. Frontiers in microbiology, 102351. https://doi.org/10.3389/fmicb.2019.02351
Harvey, Kate L, et al. "The Diverse Functional Roles of Elongation Factor Tu (EF-Tu) in Microbial Pathogenesis." Frontiers in microbiology vol. 10 (2019): 2351. doi: https://doi.org/10.3389/fmicb.2019.02351
Harvey KL, Jarocki VM, Charles IG, Djordjevic SP. The Diverse Functional Roles of Elongation Factor Tu (EF-Tu) in Microbial Pathogenesis. Front Microbiol. 2019 Oct 24;10:2351. doi: 10.3389/fmicb.2019.02351. eCollection 2019. PMID: 31708880; PMCID: PMC6822514.
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Front Microbiol. 2019 Oct 24;10:2351. doi: 10.3389/fmicb.2019.02351. eCollection 2019.

The Diverse Functional Roles of Elongation Factor Tu (EF-Tu) in Microbial Pathogenesis.

Frontiers in microbiology

Kate L Harvey, Veronica M Jarocki, Ian G Charles, Steven P Djordjevic

Affiliations

  1. The ithree Institute, University of Technology Sydney, Ultimo, NSW, Australia.
  2. Quadram Institute, Norwich, United Kingdom.
  3. Norwich Medical School, Norwich, United Kingdom.

PMID: 31708880 PMCID: PMC6822514 DOI: 10.3389/fmicb.2019.02351

Abstract

Elongation factor thermal unstable Tu (EF-Tu) is a G protein that catalyzes the binding of aminoacyl-tRNA to the A-site of the ribosome inside living cells. Structural and biochemical studies have described the complex interactions needed to effect canonical function. However, EF-Tu has evolved the capacity to execute diverse functions on the extracellular surface of both eukaryote and prokaryote cells. EF-Tu can traffic to, and is retained on, cell surfaces where can interact with membrane receptors and with extracellular matrix on the surface of plant and animal cells. Our structural studies indicate that short linear motifs (SLiMs) in surface exposed, non-conserved regions of the molecule may play a key role in the moonlighting functions ascribed to this ancient, highly abundant protein. Here we explore the diverse moonlighting functions relating to pathogenesis of EF-Tu in bacteria and examine putative SLiMs on surface-exposed regions of the molecule.

Copyright © 2019 Harvey, Jarocki, Charles and Djordjevic.

Keywords: EF-Tu; adhesion; bacteria; chaperone activities; moonlighting

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