Display options
Cite
Park JY, Chae S, Kim CS, et al. Role of nociceptin/orphanin FQ and nociceptin opioid peptide receptor in depression and antidepressant effects of nociceptin opioid peptide receptor antagonists. Korean J Physiol Pharmacol. 2019;23(6):427-448doi: 10.4196/kjpp.2019.23.6.427.
Park, J. Y., Chae, S., Kim, C. S., Kim, Y. J., Yi, H. J., Han, E., Joo, Y., Hong, S., Yun, J. W., Kim, H., & Shin, K. H. (2019). Role of nociceptin/orphanin FQ and nociceptin opioid peptide receptor in depression and antidepressant effects of nociceptin opioid peptide receptor antagonists. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 23(6), 427-448. https://doi.org/10.4196/kjpp.2019.23.6.427
Park, Jong Yung, et al. "Role of nociceptin/orphanin FQ and nociceptin opioid peptide receptor in depression and antidepressant effects of nociceptin opioid peptide receptor antagonists." The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology vol. 23,6 (2019): 427-448. doi: https://doi.org/10.4196/kjpp.2019.23.6.427
Park JY, Chae S, Kim CS, Kim YJ, Yi HJ, Han E, Joo Y, Hong S, Yun JW, Kim H, Shin KH. Role of nociceptin/orphanin FQ and nociceptin opioid peptide receptor in depression and antidepressant effects of nociceptin opioid peptide receptor antagonists. Korean J Physiol Pharmacol. 2019 Nov;23(6):427-448. doi: 10.4196/kjpp.2019.23.6.427. Epub 2019 Oct 24. PMID: 31680765; PMCID: PMC6819898.
Copy Download .nbib Format: NLM
Share it on

Korean J Physiol Pharmacol. 2019 Nov;23(6):427-448. doi: 10.4196/kjpp.2019.23.6.427. Epub 2019 Oct 24.

Role of nociceptin/orphanin FQ and nociceptin opioid peptide receptor in depression and antidepressant effects of nociceptin opioid peptide receptor antagonists.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Jong Yung Park, Suji Chae, Chang Seop Kim, Yoon Jae Kim, Hyun Joo Yi, Eunjoo Han, Youngshin Joo, Surim Hong, Jae Won Yun, Hyojung Kim, Kyung Ho Shin

Affiliations

  1. Department of Pharmacology, Korea University College of Medicine, Seoul 02841, Korea.

PMID: 31680765 PMCID: PMC6819898 DOI: 10.4196/kjpp.2019.23.6.427

Abstract

Nociceptin/orphanin FQ (N/OFQ) and its receptor, nociceptin opioid peptide (NOP) receptor, are localized in brain areas implicated in depression including the amygdala, bed nucleus of the stria terminalis, habenula, and monoaminergic nuclei in the brain stem. N/OFQ inhibits neuronal excitability of monoaminergic neurons and monoamine release from their terminals by activation of G protein-coupled inwardly rectifying K

Copyright © 2019 The Korean Physiological Society and The Korean Society of Pharmacology.

Keywords: Antidepressive agents; Depression; Neuropeptide; Receptors, drug

Conflict of interest statement

CONFLICTS OF INTEREST: The authors declare no conflicts of interest.

References

  1. J Neurosci. 1995 Nov;15(11):7539-47 - PubMed
  2. Life Sci. 2002 Nov 29;72(2):163-71 - PubMed
  3. J Psychopharmacol. 2017 Jun;31(6):691-703 - PubMed
  4. J Comp Neurol. 1999 Oct 4;412(4):563-605 - PubMed
  5. Neuropharmacology. 1996 Mar;35(3):243-8 - PubMed
  6. Br J Pharmacol. 2002 Feb;135(3):800-6 - PubMed
  7. J Neurosci. 2001 Sep 1;21(17):6940-8 - PubMed
  8. Neuropharmacology. 2008 Dec;55(7):1114-20 - PubMed
  9. Ann N Y Acad Sci. 2009 Oct;1179:144-52 - PubMed
  10. Neuron. 2002 Mar 28;34(1):13-25 - PubMed
  11. J Neurosci. 1996 Nov 1;16(21):6657-64 - PubMed
  12. Front Pharmacol. 2019 Feb 05;10:60 - PubMed
  13. Behav Brain Res. 2007 Dec 3;184(2):167-73 - PubMed
  14. Pharmacol Res Perspect. 2016 Nov 07;4(6):e00275 - PubMed
  15. Br J Pharmacol. 2002 May;136(2):303-11 - PubMed
  16. Biol Psychiatry. 2001 Aug 15;50(4):260-5 - PubMed
  17. Neuroscience. 2001;102(3):541-53 - PubMed
  18. Eur J Pharmacol. 2013 Jan 15;699(1-3):200-6 - PubMed
  19. Neuroscience. 1993 Dec;57(4):1047-60 - PubMed
  20. J Physiol. 2001 Aug 1;534(Pt 3):849-59 - PubMed
  21. Neuropeptides. 2007 Dec;41(6):399-410 - PubMed
  22. Neurosci Lett. 2001 May 11;303(3):173-6 - PubMed
  23. Nature. 1995 Oct 12;377(6549):532-5 - PubMed
  24. PLoS One. 2018 Oct 1;13(10):e0204980 - PubMed
  25. Br J Pharmacol. 2015 Jan;172(2):606-14 - PubMed
  26. Brain Res. 2008 Aug 11;1224:63-8 - PubMed
  27. Br J Pharmacol. 2004 Sep;143(1):53-62 - PubMed
  28. Br J Pharmacol. 1996 Dec;119(8):1614-8 - PubMed
  29. Brain Res. 1995 Feb 20;672(1-2):261-75 - PubMed
  30. Behav Brain Res. 2006 Apr 3;168(2):280-8 - PubMed
  31. Am J Psychiatry. 2003 Aug;160(8):1516-8 - PubMed
  32. Biol Psychiatry. 2008 Feb 15;63(4):353-9 - PubMed
  33. Br J Pharmacol. 2002 Aug;136(8):1178-84 - PubMed
  34. Dev Neurobiol. 2013 Oct;73(10):769-84 - PubMed
  35. J Neuroendocrinol. 2012 Dec;24(12):1527-41 - PubMed
  36. J Neurochem. 1999 Oct;73(4):1502-9 - PubMed
  37. CMAJ. 2009 Feb 3;180(3):305-13 - PubMed
  38. Horm Behav. 2014 Apr;65(4):363-71 - PubMed
  39. Brain Res. 2010 Dec 17;1366:141-8 - PubMed
  40. Neuropharmacology. 2010 Sep;59(3):190-200 - PubMed
  41. Gene. 1996 Jun 1;171(2):255-60 - PubMed
  42. Psychopharmacology (Berl). 2001 Feb;154(1):1-7 - PubMed
  43. Eur J Neurosci. 2003 May;17(9):1987-90 - PubMed
  44. Brain Res. 2013 Jul 3;1520:51-60 - PubMed
  45. Neuropharmacology. 2010 Feb;58(2):457-64 - PubMed
  46. Curr Protoc Neurosci. 2009 Oct;Chapter 9:Unit 9.32 - PubMed
  47. J Neurochem. 2008 Oct;107(2):544-56 - PubMed
  48. Neurosci Lett. 1996 Aug 23;214(2-3):131-4 - PubMed
  49. J Psychiatr Res. 2009 Sep;43(14):1175-84 - PubMed
  50. J Comp Neurol. 1996 Apr 29;368(2):229-51 - PubMed
  51. IDrugs. 2008 Mar;11(3):189-97 - PubMed
  52. Psychopharmacology (Berl). 2018 Aug;235(8):2195-2220 - PubMed
  53. Br J Pharmacol. 2002 Aug;136(7):1065-71 - PubMed
  54. Psychopharmacology (Berl). 2016 Jul;233(13):2525-32 - PubMed
  55. J Neurosci. 2002 Apr 15;22(8):3251-61 - PubMed
  56. Biol Psychiatry. 2012 Aug 15;72(4):258-65 - PubMed
  57. J Neuroendocrinol. 2007 Jul;19(7):531-42 - PubMed
  58. Neuroscience. 2004;127(4):929-40 - PubMed
  59. Br J Pharmacol. 1996 May;118(2):205-7 - PubMed
  60. Brain Res Mol Brain Res. 1997 Apr;45(1):117-26 - PubMed
  61. J Neurophysiol. 2001 Apr;85(4):1384-94 - PubMed
  62. Neurobiol Dis. 2017 Jan;97(Pt B):119-126 - PubMed
  63. J Neuroendocrinol. 2009 Nov;21(11):888-97 - PubMed
  64. Br J Pharmacol. 1999 May;127(1):300-8 - PubMed
  65. Neuroscience. 2006 Sep 15;141(4):2051-7 - PubMed
  66. J Physiol. 2012 Apr 1;590(7):1655-67 - PubMed
  67. J Neurobiol. 2006 Mar;66(4):361-77 - PubMed
  68. J Clin Invest. 2008 Jul;118(7):2471-81 - PubMed
  69. Handb Exp Pharmacol. 2019;254:399-415 - PubMed
  70. Neuroreport. 2002 Jul 2;13(9):1137-40 - PubMed
  71. J Physiol. 2011 Jul 1;589(Pt 13):3103-14 - PubMed
  72. Eur J Neurosci. 1999 Oct;11(10):3610-6 - PubMed
  73. Brain Res. 1995 Jun 5;682(1-2):215-21 - PubMed
  74. Life Sci. 1985 Dec 16;37(24):2249-55 - PubMed
  75. Biol Psychiatry. 2004 Nov 1;56(9):640-50 - PubMed
  76. Eur J Neurosci. 2007 Dec;26(12):3395-401 - PubMed
  77. Biochem Biophys Res Commun. 2007 May 11;356(3):582-6 - PubMed
  78. J Neurosci. 1992 Apr;12(4):1335-50 - PubMed
  79. Eur Neuropsychopharmacol. 2012 Jan;22(1):1-16 - PubMed
  80. Naunyn Schmiedebergs Arch Pharmacol. 1998 Oct;358(4):418-22 - PubMed
  81. Neuropsychopharmacology. 2007 Dec;32(12):2500-10 - PubMed
  82. FEBS Lett. 1994 Jun 27;347(2-3):284-8 - PubMed
  83. J Neuroendocrinol. 2006 Aug;18(8):629-31 - PubMed
  84. J Neurosci. 2002 Feb 1;22(3):718-27 - PubMed
  85. Psychopharmacology (Berl). 1995 Sep;121(1):66-72 - PubMed
  86. CNS Neurosci Ther. 2018 Nov;24(11):994-1003 - PubMed
  87. Neuroendocrinology. 1999 May;69(5):385-96 - PubMed
  88. J Neurosci. 1998 Oct 15;18(20):8133-44 - PubMed
  89. Mol Pharmacol. 2002 May;61(5):1017-24 - PubMed
  90. Brain Res. 2002 Sep 13;949(1-2):71-8 - PubMed
  91. J Comp Neurol. 2002 Mar 18;444(4):358-68 - PubMed
  92. FEBS Lett. 1994 Jun 27;347(2-3):279-83 - PubMed
  93. Neuropeptides. 2009 Dec;43(6):507-14 - PubMed
  94. Int J Neuropsychopharmacol. 2008 Dec;11(8):1047-61 - PubMed
  95. Biol Psychiatry. 2018 Jul 1;84(1):46-54 - PubMed
  96. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10827-32 - PubMed
  97. Eur J Pharmacol. 1997 Apr 23;325(1):29-34 - PubMed
  98. Cold Spring Harb Perspect Biol. 2015 Sep 01;7(9):a021303 - PubMed
  99. Brain Res. 1995 Jun 5;682(1-2):189-96 - PubMed
  100. Neurosci Lett. 1997 Jul 11;230(1):33-6 - PubMed
  101. Eur J Neurosci. 1998 Jan;10(1):20-33 - PubMed
  102. Naunyn Schmiedebergs Arch Pharmacol. 2002 Feb;365(2):164-7 - PubMed
  103. Neuropsychopharmacology. 2016 Jan;41(1):3-23 - PubMed
  104. Nat Neurosci. 2006 Jan;9(1):31-40 - PubMed
  105. Peptides. 2015 Oct;72:95-103 - PubMed
  106. Science. 1995 Nov 3;270(5237):792-4 - PubMed
  107. Science. 2012 Oct 5;338(6103):68-72 - PubMed
  108. Zhonghua Yi Xue Za Zhi. 2009 Apr 7;89(13):916-8 - PubMed
  109. Depress Anxiety. 2000;12 Suppl 1:2-19 - PubMed
  110. Brain Res Bull. 2006 Jul 31;70(3):221-7 - PubMed
  111. J Physiol. 1999 Jun 1;517 ( Pt 2):431-45 - PubMed
  112. Gene. 1999 Oct 1;238(2):427-36 - PubMed
  113. Zhonghua Fu Chan Ke Za Zhi. 2003 Dec;38(12):727-8 - PubMed
  114. Naunyn Schmiedebergs Arch Pharmacol. 2004 Jun;369(6):547-53 - PubMed
  115. Psychopharmacology (Berl). 1998 Apr;136(3):299-303 - PubMed
  116. Neurol Sci. 2012 Dec;33(6):1233-7 - PubMed
  117. Br J Pharmacol. 1996 Apr;117(8):1609-11 - PubMed
  118. Arch Gen Psychiatry. 2004 Jun;61(6):556-63 - PubMed
  119. J Neurochem. 1999 Jul;73(1):179-86 - PubMed
  120. Biol Sex Differ. 2019 Feb 12;10(1):9 - PubMed
  121. Trends Neurosci. 1995 Jan;18(1):22-9 - PubMed
  122. Neuropsychopharmacology. 2004 Jan;29(1):59-71 - PubMed
  123. Br J Pharmacol. 2000 May;130(2):425-33 - PubMed
  124. J Neuroendocrinol. 2003 Jan;15(1):69-74 - PubMed
  125. Eur J Pharmacol. 2004 Feb 6;485(1-3):197-200 - PubMed
  126. J Comp Neurol. 1999 Apr 19;406(4):503-47 - PubMed
  127. Nat Med. 2012 Sep;18(9):1413-7 - PubMed
  128. Neuropsychopharmacology. 2016 Jun;41(7):1803-12 - PubMed
  129. Psychoneuroendocrinology. 2010 Aug;35(7):1100-12 - PubMed
  130. Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15506-11 - PubMed
  131. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):4035-9 - PubMed
  132. Neurochem Int. 2009 May-Jun;54(5-6):378-84 - PubMed
  133. Neuroendocrinology. 2013;98(1):60-72 - PubMed
  134. J Pharmacol Exp Ther. 2002 Oct;303(1):188-95 - PubMed
  135. J Affect Disord. 2011 Nov;134(1-3):483-7 - PubMed
  136. Biol Psychiatry. 1999 May 1;45(9):1085-98 - PubMed
  137. J Physiol. 1998 May 15;509 ( Pt 1):47-58 - PubMed
  138. J Neurophysiol. 2015 Sep;114(3):1713-24 - PubMed
  139. Neuroscience. 2007 Jun 15;147(1):106-16 - PubMed
  140. Trends Pharmacol Sci. 1997 Aug;18(8):293-300 - PubMed
  141. J Psychopharmacol. 2015 May;29(5):526-44 - PubMed
  142. CNS Drug Rev. 2006 Summer;12(2):123-34 - PubMed
  143. Eur J Pharmacol. 2002 Feb 2;436(3):197-205 - PubMed
  144. Peptides. 2000 Jul;21(7):1023-9 - PubMed
  145. J Neurosci. 1994 Mar;14(3 Pt 1):1106-13 - PubMed
  146. Neurochem Int. 2013 Feb;62(3):314-23 - PubMed
  147. Br J Pharmacol. 2003 Jan;138(1):91-8 - PubMed
  148. Neurosignals. 2002 Jul-Aug;11(4):197-212 - PubMed
  149. Psychopharmacology (Berl). 2016 Oct;233(19-20):3553-63 - PubMed
  150. Psychopharmacology (Berl). 2009 Dec;207(2):173-89 - PubMed
  151. J Physiol. 2001 Oct 1;536(Pt 1):35-47 - PubMed
  152. Pharmacol Biochem Behav. 2002 Aug;73(1):123-9 - PubMed
  153. Neuroendocrinology. 1998 Feb;67(2):73-82 - PubMed
  154. Br J Pharmacol. 1999 Sep;128(1):103-7 - PubMed
  155. Neuroreport. 2001 Oct 8;12(14):3159-63 - PubMed
  156. Eur J Pharmacol. 1999 Jan 22;365(2-3):281-9 - PubMed
  157. J Pharmacol Exp Ther. 2007 Jun;321(3):968-74 - PubMed
  158. Stress. 2012 Jul;15(4):378-84 - PubMed
  159. J Neurosci. 2003 Jan 1;23(1):349-57 - PubMed
  160. Br J Pharmacol. 2006 Jul;148(6):795-806 - PubMed
  161. Brain Res. 2000 Feb 7;855(1):171-5 - PubMed
  162. J Neurochem. 2001 Dec;79(6):1113-21 - PubMed
  163. Psychopharmacology (Berl). 2018 Nov;235(11):3093-3102 - PubMed
  164. FEBS Lett. 1994 Mar 14;341(1):33-8 - PubMed
  165. J Neurosci Res. 2005 Aug 15;81(4):488-96 - PubMed
  166. Neuroscience. 2002;115(2):637-43 - PubMed
  167. Mol Pharmacol. 2013 May;83(5):907-18 - PubMed

Publication Types