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Marshall JM, Raban RR, Kandul NP, et al. Winning the Tug-of-War Between Effector Gene Design and Pathogen Evolution in Vector Population Replacement Strategies. Front Genet. 2019;10:1072doi: 10.3389/fgene.2019.01072.
Marshall, J. M., Raban, R. R., Kandul, N. P., Edula, J. R., León, T. M., & Akbari, O. S. (2019). Winning the Tug-of-War Between Effector Gene Design and Pathogen Evolution in Vector Population Replacement Strategies. Frontiers in genetics, 101072. https://doi.org/10.3389/fgene.2019.01072
Marshall, John M, et al. "Winning the Tug-of-War Between Effector Gene Design and Pathogen Evolution in Vector Population Replacement Strategies." Frontiers in genetics vol. 10 (2019): 1072. doi: https://doi.org/10.3389/fgene.2019.01072
Marshall JM, Raban RR, Kandul NP, Edula JR, León TM, Akbari OS. Winning the Tug-of-War Between Effector Gene Design and Pathogen Evolution in Vector Population Replacement Strategies. Front Genet. 2019 Oct 30;10:1072. doi: 10.3389/fgene.2019.01072. eCollection 2019. PMID: 31737050; PMCID: PMC6831721.
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Front Genet. 2019 Oct 30;10:1072. doi: 10.3389/fgene.2019.01072. eCollection 2019.

Winning the Tug-of-War Between Effector Gene Design and Pathogen Evolution in Vector Population Replacement Strategies.

Frontiers in genetics

John M Marshall, Robyn R Raban, Nikolay P Kandul, Jyotheeswara R Edula, Tomás M León, Omar S Akbari

Affiliations

  1. Division of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, CA, United States.
  2. Innovative Genomics Institute, Berkeley, CA, United States.
  3. Section of Cell and Developmental Biology, University of California, San Diego, CA, United States.
  4. Tata Institute for Genetics and Society, University of California, San Diego, CA, United States.

PMID: 31737050 PMCID: PMC6831721 DOI: 10.3389/fgene.2019.01072

Abstract

While efforts to control malaria with available tools have stagnated, and arbovirus outbreaks persist around the globe, the advent of clustered regularly interspaced short palindromic repeat (CRISPR)-based gene editing has provided exciting new opportunities for genetics-based strategies to control these diseases. In one such strategy, called "population replacement", mosquitoes, and other disease vectors are engineered with effector genes that render them unable to transmit pathogens. These effector genes can be linked to "gene drive" systems that can bias inheritance in their favor, providing novel opportunities to replace disease-susceptible vector populations with disease-refractory ones over the course of several generations. While promising for the control of vector-borne diseases on a wide scale, this sets up an evolutionary tug-of-war between the introduced effector genes and the pathogen. Here, we review the disease-refractory genes designed to date to target

Copyright © 2019 Marshall, Raban, Kandul, Edula, León and Akbari.

Keywords: Zika; clustered regularly interspaced short palindromic repeats; clustered regularly interspaced short palindromic repeats–associated protein 9; dengue; gene drive; homing; malaria

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